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This meeting took place in 2007

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Mast Cells, Basophils, and IgE: Host Defense and Disease (A6)

Organizer(s) Joshua A. Boyce, K. Frank Austen, Jean S. Marshall and William E. Paul
January 20—24, 2007
Copper Mountain Resort • Copper Mountain, Colorado USA
Abstract Deadline: Sep 20, 2006
Late Abstract Deadline: Oct 23, 2006
Scholarship Deadline: Sep 20, 2006
Early Registration Deadline: Nov 20, 2006

Supported by the Director's Fund

Summary of Meeting:
Mast cells, basophils, and IgE form a strongly conserved interface between innate and adaptive mucosal immune systems. Each cell is a sensitive detector of environmental perturbations, to which they respond by generating and releasing a distinctive profile of mediators. The development of progressively more sophisticated experimental models has permitted the recognition of clear-cut and novel functions for mast cells and basophils in mediating effector cell recruitment, facilitating antigen presentation, inducing and amplifying immune responses, and modulating host responses in disease models. This program will focus on new aspects of development and trafficking of both cell lineages, homeostatic controls of cell activation, in-depth examination of mast cell and basophil-derived mediators, the roles of these cells in both allergic (IgE-mediated) and non-allergic disease, and therapeutic modulation of their roles in both mouse models and human disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time




Keynote Address

Bighorn B
William E. Paul, NIAID, National Institutes of Health, USA
Searching for IL-4 or How I Came to Love the Basophil



Development and Trafficking

Bighorn B
* Dean D. Metcalfe, NIAID, National Institutes of Health, USA

Koichi Akashi, Kyushu University, Japan
The Origin and Developmental Mechanism of Mast Cells, Basophils and Eosinophils

Constance Oliver, Faculty of Medicine at Ribeirão Preto, University of São Paulo, Brazil
Recruitment and Homing of Mast Cell Precursors, Immature and Mature Mast Cells

Charlie Weller, Wellcome Trust, UK
Activated Mature Mast Cells can Recruit Progenitors that Express the BLT1 Receptor

Michael F. Gurish, Brigham and Women's Hospital, Harvard Medical School, USA
Defining the Mechanisms Controlling Basal Homing and Inflammatory Recruitment of Committed Mast Cell Progenitors to the Intestine and Lung

Scott Byrne, University of Sydney, Australia
Short Talk: CXCR4-Mediated Mast Cell Migration to Lymph Nodes is Essential for UV-Induced Immune Suppression

Coffee Break

Poster Setup

Bighorn C
Poster Viewing

Bighorn C
Workshop 1: Novel Functions of Mast Cell Proteases

Bighorn B
* Gunnar Pejler, Swedish University of Agricultural Sciences, Sweden

* Richard L. Stevens, Brigham and Women's Hospital, USA
Ancient Origin of Connective Tissue Mast Cells and their Granule and Lipid Mediators

Magnus Åbrink, Uppsala University, Sweden
Serglycin-Deficiency in Ageing Mice Leads to Splenomegaly, Enlarged Peyer’s Patches and Bronchus-Associated Lymphoid Tissues (BALTs)

Tiago Braga Moreira de Campos Carlos, Swedish University of Agricultural Sciences, Sweden
Serglycin Proteoglycan is Required for Secretory Granule Integrity in Mucosal Mast Cells

Hans-Reimer Rodewald, Ulm University, Germany
A Single Mast Cell Enzyme, Carboxypeptidase A, is Essential for Protection against Snake Venom Sarafotoxin

Shakeel M. Thakurdas, University of Texas, MD Anderson Cancer Center, USA
Mouse Mast Cell Protease 6 is Essential in Defense against Gram- Negative Bacterial Infection

Katherine R. Groschwitz, Cincinnati Children's Hospital Medical Center, USA
Intestinal Expression of Interleukin 9 (IL-9) Induces Mast Cell-Mediated Intestinal Permeability

Kichul Shin, Seoul National University Hospital, South Korea
Mast Cell Tryptase mMCP-6 Enhances Skeletal Muscle Larvae Necrosis and Tissue Eosinophilia in Trichinella spiralis Infection

Coffee Available

What’s New in Signal Transduction and Transcription

Bighorn B
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Contrasting Mechanisms of Transcriptional Control in Mast Cells and Th2 Cells

Tatsuki R. Kataoka, Osaka University, Japan
STAT4 Expression and Th1-Polarizing Characteristics of Connective Tissue Type Mast Cells

Christine Tkaczyk, Nabi Biopharmaceuticals, USA
Role of the Transmembrane Adaptor Protein (TRAP) NTAL/LAB/LAT2 (NTAL) in Mast Cell Activation

Ehud Razin, Hebrew University, Hadassah Medical School, Israel
Lysyl tRNA Synthetase is an Intracellular, Immunologically Activated Signaling Molecule in Mast Cells

Social Hour with Lite Bites

Bighorn C
Poster Session 1

Bighorn C



Innate Immunity

Bighorn B
* Jean S. Marshall, Dalhousie University, Canada
Selective Mast Cell Responses to Pathogen Products

Matthias Mack, University of Regensburg, Germany
Basophils as Antigen Capturing Cells and their Role in Immune Regulation

Marcus Maurer, Charité - Universitätsmedizin Berlin, Germany
Mast Cell-Dependent Homeostasis in Sepsis- The Role of Endothelin 1

John T. Schroeder, Johns Hopkins Asthma and Allergy Center, USA
Innate Immunity in Modulating Basophil Responses

Marc Becker, Institute for Immunology, Germany
Short Talk: Murine Mast Cells Prime the Development of Cytotoxic T Cell Responses by Epicutaneous Peptide Vaccination with TLR7 Ligand as Adjuvant

Jared M. Brown, University of Colorado Anshutz Medical Campus, USA
Short Talk: Preservation of Innate and Acquired Immune Function in Mast Cells Following Radiation Exposure

Coffee Break

Poster Setup

Bighorn C
Poster Viewing

Bighorn C
Workshop 2: Mast Cells in Acquired Immunity

Bighorn B
* Melissa A. Brown, Northwestern University, USA

* A. Dean Befus, University of Alberta, Canada

Jeoung-Sook Shin, University of California, San Francisco, USA
Harboring of Particulate Allergens within Secretory Compartments by Mast Cells Following IgE/FcepsilonRI-Lipid Raft Mediated Phagocytosis

Clinton B. Mathias, Children's Hospital, Harvard Medical School, USA
Allergen-Driven Mast Cell Expansion in the Airways is Driven by IgE Antibodies

Duraisamy Kempuraj, Tufts University School of Medicine, USA
Myelin Basic Protein Stimulates Human Mast Cells and Together they Activate T Cells: Inhibition by Luteolin and Implications for Multiple Sclerosis

Guy J.T. Delespesse, Centre de Recherche du CHUM, Canada
Thymic Stromal Lymphopoietin (TSLP) is a Potent Activator of Human Mast Cells

Michael Stassen, Johannes Gutenberg University, Germany
p38 MAP Kinase and GATA-1 are Part of a Mast Cell-Specific Signaling Network which Drives the Expression of the Th2-Type Cytokine IL-9

J. Bruce Sundstrom, NIAID, National Institutes of Health, USA
IgE Enhances CXCR4 Expression and Susceptibility to Infection with CXCR4-Tropic HIV-1 During Ontogeny of Human Mast Cells

Anna Erdei, Eötvös University, Hungary
The Effect of Complement-Derived Inhibitory Peptides on FcepsiloneRI-Clustering Induced Mast Cell Signaling

Coffee Available

Novel Aspects of Mast Cell and Basophil Function in Inflammation and Disease

Bighorn B
* Erwin W. Gelfand, National Jewish Medical and Research Center, USA
Mast Cell-T Cell Interactions: A New Paradigm

David R. Beier, Brigham and Women's Hospital, Harvard Medical School, USA
Mast Cells in the Regulation of Naive Airway Responsiveness; Lessons from A/J Mice

Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan
Basophils Regulate Chronic Allergic Inflammation

Silvana Balzar, University of Pittsburgh, USA
Short Talk: Mast Cell Phenotypes in Large Airway Smooth Muscle and Submucosa of Normal Subjects and Subjects with Asthma do not Correlate with Lung Function

Social Hour with Lite Bites

Bighorn C
Poster Session 2

Bighorn C



Negative Regulation of Mast Cell and Basophil Activation

Bighorn B
* Juan Rivera, , USA
Lipid Regulators of IgE/Fc Epsilon Homeostasis and Function

Marc Daëron, Institut Pasteur, France
Modulation of Mast Cell and Basophil Activation by FcgammaRIIB

Jean-Pierre Kinet, Beth Israel Deaconess Medical Center and Harvard Medical School, USA
Calcium Signaling in Mast Cells

See-ying Tam, Stanford University, USA
Regulation of Mast Cell Activation by RabGEF1/Rabex-5

Coffee Break

Workshop 3: Differences in Biologic Outcomes between the Two Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)

Bighorn B
* K. Frank Austen, Harvard Medical School, USA

* George H. Caughey, University of California, San Francisco, USA
W/W-v Versus W-sh Mast Cell-Deficient Mice: Pros, Cons and Challenges

Michele Grimbaldeston, Centre for Cancer Biology, Australia
Comparative Studies of Mast Cell Biology in vivo Using C57BL/6-KitW-sh/W-sh versus WB x C57BL/6 F1 (WBB6F1)-KitW/W-v Mice

Howard R. Katz, Brigham and Women's Hospital, Harvard Medical School, USA
Inflammatory Arthritis is Intact in KitW-sh/W-sh Mice and is Exacerbated by LILRB4 Deficiency

Wojciech Dawicki, University of Saskatchewan, Canada
Mast Cell Activation Selectively Promotes the Recruitment of Multiple Dendritic Cell Subpopulations to the Lymph Node

Ernestina Melicoff, University of Texas MD Anderson Cancer Center, USA
Selective Defect in Mast Cell Regulated Exocytosis: Its Importance in Allergy and Infection

Guo-Ping Shi, Brigham and Women's Hospital, USA
Mast Cell, a Novel Aortic Cell Type, Controls the Pathogenesis of Abdominal Aortic Aneurysms

Barry K. Wershil, Albert Einstein College of Medicine, USA
Substance P-Induced Gastric Inflammation Requires Mast Cell Production of Leukotrienes but not Tumor Necrosis Factor alpha

Paul Wolters, University of California, San Francisco, USA
Mast Cell IL-6 Improves Survival Following Klebsiella Pneumonia and Sepsis by Enhancing Neutrophil Killing

Coffee Available

Regulation of Activation by Lysophospholipids and Lipids

Bighorn B
Sarah Spiegel, Virginia Commonwealth University, USA
Sphingosine-1-Phosphate in Mast Cell Activation

Ana Olivera, NIAMS, National Institutes of Health, USA
Sphingosine Kinases are Determinants of Mast Cell Function and Anaphylaxis

* Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA
Cysteinyl Leukotrienes as Regulators of Mast Cell Function

Stefen A. Boehme, Actimis Pharmaceuticals, USA
Short Talk: Murine Bone Marrow Derived Mast Cells Express the CRTH2 Receptor

Tae Chul Moon, University of Alberta, Canada
Short Talk: Exogenous Nitric Oxide Regulates Cyclooxygenase-2 Expression and Prostaglandin D2 Generation In Mouse Bone Marrow-Derived Mast Cells

Social Hour with Lite Bites

Bighorn C

Bighorn C



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1 R13 AI071684-01

We gratefully acknowledge additional support for this conference from:

UCB Celltech

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