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This meeting took place in 2007
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Immunologic Memory (C4)
Organizer(s) Robert A. Seder, Susan L. Swain, Rafi Ahmed and Antonio Lanzavecchia
March 3—8, 2007
Eldorado Hotel & Spa • Santa Fe, NM USA
Abstract Deadline: Nov 3, 2006
Late Abstract Deadline: Dec 4, 2006
Scholarship Deadline: Nov 3, 2006
Early Registration Deadline: Jan 3, 2007
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Immune memory has a critical role in mediating protection against infections as well as potentiating allergic and autoimmune diseases. Hence a thorough understanding of the molecular and cellular mechanisms regulating adaptive memory immunity will have potentially important clinical application. Recent developments in how the innate immune response influences adaptive immunity combined with better methods to characterize the phenotype, magnitude and functional quality of such responses have substantially improved our understanding in this area. Major problems still relate to difficulties in eliciting long-term T cell responses with current vaccines in humans. The goals of the meeting will be to focus on basic mechanisms regarding how T and B cells are programmed to elicit and sustain immunity. The program is designed to integrate information from both mouse and humans studies to encompass all relevant areas related to control of memory T and B cell responses. In summary, this meeting should greatly enhance translational research that will impact vaccines and interventions for infectious disease, cancer and autoimmune/allergic diseases.
View Scholarships/Awards
Immune memory has a critical role in mediating protection against infections as well as potentiating allergic and autoimmune diseases. Hence a thorough understanding of the molecular and cellular mechanisms regulating adaptive memory immunity will have potentially important clinical application. Recent developments in how the innate immune response influences adaptive immunity combined with better methods to characterize the phenotype, magnitude and functional quality of such responses have substantially improved our understanding in this area. Major problems still relate to difficulties in eliciting long-term T cell responses with current vaccines in humans. The goals of the meeting will be to focus on basic mechanisms regarding how T and B cells are programmed to elicit and sustain immunity. The program is designed to integrate information from both mouse and humans studies to encompass all relevant areas related to control of memory T and B cell responses. In summary, this meeting should greatly enhance translational research that will impact vaccines and interventions for infectious disease, cancer and autoimmune/allergic diseases.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, MARCH 3
SUNDAY, MARCH 4
MONDAY, MARCH 5
TUESDAY, MARCH 6
WEDNESDAY, MARCH 7
THURSDAY, MARCH 8
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, MARCH 3
19:30—20:30
Keynote Address
Peter C. Doherty,
University of Melbourne, Australia
Thinking About T Cell Memory
Thinking About T Cell Memory
08:00—11:00
CD4+ T Cell Memory
*
Marc K. Jenkins,
University of Minnesota Medical School, USA
Enumeration of Polyclonal Antigen-Specific CD4+ T Cells in Naïve and Immunized Individuals.
Enumeration of Polyclonal Antigen-Specific CD4+ T Cells in Naïve and Immunized Individuals.
Charles D. Surh,
La Jolla Institute for Allergy and Immunology, USA
Regulation of Memory CD4+ T cell Selection and Homeostasis
Regulation of Memory CD4+ T cell Selection and Homeostasis
Robert A. Seder,
NIAID, National Institutes of Health, USA
The Quality of a Th1 Response Determines Protection
The Quality of a Th1 Response Determines Protection
Rafick Sekaly,
Case Western Reserve University, USA
Short Talk: Survival Pathways of Memory T Cells: Role of FOXO3a
Short Talk: Survival Pathways of Memory T Cells: Role of FOXO3a
14:30—16:30
Workshop 1: Immunodominance and T Cell Repertoire
*
Liisa K. Selin,
University of Massachusetts Medical School, USA
Ann B. Hill,
Oregon Health & Science University, USA
The CD8 T Cell Response to Murine Cytomegalovirus Undergoes a Dramatic Alteration in Immunodominance Hierarchy Between Acute and Chronic Infection
The CD8 T Cell Response to Murine Cytomegalovirus Undergoes a Dramatic Alteration in Immunodominance Hierarchy Between Acute and Chronic Infection
David Price,
Cardiff University School of Medicine, UK
Public Clonotype Usage in Virus-Specific CD8+ T Cell Populations: Mechanisms of TCR Sharing and Biological Implications
Public Clonotype Usage in Virus-Specific CD8+ T Cell Populations: Mechanisms of TCR Sharing and Biological Implications
Vanessa Venturi,
University of New South Wales, Australia
Methods for Comparing Samples of the T Cell Receptor Repertoire
Methods for Comparing Samples of the T Cell Receptor Repertoire
Julie Leignadier,
LICR, University of Laussane, Switzerland
TCR Signals Regulate the Generation and Maintenance of Memory T Cells
TCR Signals Regulate the Generation and Maintenance of Memory T Cells
Scott N. Mueller,
University of Melbourne, Australia
Closing the Door on Immune Responses: Regulation of Homeostatic Chemokines in Lymphoid Organs
Closing the Door on Immune Responses: Regulation of Homeostatic Chemokines in Lymphoid Organs
David J. Topham,
University of Rochester Medical Center, USA
The Alpha1 Beta1 Integrin VLA-1 and TNF-Alpha Protect Influenza Specific CD8+ Effector T Cells from Apoptosis during Acute Infection
The Alpha1 Beta1 Integrin VLA-1 and TNF-Alpha Protect Influenza Specific CD8+ Effector T Cells from Apoptosis during Acute Infection
17:00—19:00
B Cell Memory
*
Michael G. McHeyzer-Williams,
The Scripps Research Institute, USA
Lymphoid Retention of Memory TFH Cells
Lymphoid Retention of Memory TFH Cells
Shane Crotty,
La Jolla Institute for Immunology, USA
Short Talk: Deterministic Linkage between CD4 T Cell and B Cell Specificities to a Large Viral Pathogen
Short Talk: Deterministic Linkage between CD4 T Cell and B Cell Specificities to a Large Viral Pathogen
Andreas Radbruch,
Deutsches Rheuma-Forschungszentrum, Germany
Selecting Plasma Cells to Memory
Selecting Plasma Cells to Memory
Claude-Agnès Reynaud,
Necker-Paris Medical School, France
Repertoire diversification discriminates IgM+IgD+CD27+ from switched memory B cells in humans
Repertoire diversification discriminates IgM+IgD+CD27+ from switched memory B cells in humans
08:00—11:00
Innate Immunity
*
Bali Pulendran,
Stanford University School of Medicine, USA
Modulating Vaccine Responses with Innate Immunity
Modulating Vaccine Responses with Innate Immunity
Pratima Krishna-Suvas,
University of Tennessee, USA
Short Talk: Generation and Maintenance of Antigen-Specific CD8 T Cells in the Vaginal Mucosa Following Systemic Versus Mucosal Routes of Immunization
Short Talk: Generation and Maintenance of Antigen-Specific CD8 T Cells in the Vaginal Mucosa Following Systemic Versus Mucosal Routes of Immunization
Thandi M. Onami,
Bill & Melinda Gates Foundation, USA
Short Talk: Generation and Maintenance of Antigen-Specific CD8 T Cells in the Vaginal Mucosa Following Systemic Versus Mucosal Routes of Immunization
Short Talk: Generation and Maintenance of Antigen-Specific CD8 T Cells in the Vaginal Mucosa Following Systemic Versus Mucosal Routes of Immunization
Judith N. Mandl,
National Institutes of Health, USA
Short Talk: Differences in the Induction of Cellular Immune Responses to Specific Virus Infections in Rhesus Macaques and Sooty Mangabeys Relates to Altered Innate Signalling Via Toll-Like Receptor 7 and 9
Short Talk: Differences in the Induction of Cellular Immune Responses to Specific Virus Infections in Rhesus Macaques and Sooty Mangabeys Relates to Altered Innate Signalling Via Toll-Like Receptor 7 and 9
Albert S. Bendelac,
University of Chicago, USA
'Natural Memory' NKT cells
'Natural Memory' NKT cells
Christine A. Biron,
Brown University, USA
Innate Immunity during Viral Infections
Innate Immunity during Viral Infections
14:30—16:30
Workshop 2: Aging and Memory
*
Richard J. Hodes,
NIA, National Institutes of Health, USA
*
Laura Haynes,
UConn Health, USA
The Effect of Aging on Primary and Memory Responses of CD4 T Cells
The Effect of Aging on Primary and Memory Responses of CD4 T Cells
Carl E. Ruby,
Rush University Medical Center, USA
OX40-Mediated Survival of Antigen-Activated CD4 T Cells Requires IL-12 Signaling
OX40-Mediated Survival of Antigen-Activated CD4 T Cells Requires IL-12 Signaling
C. John Luckey,
Brigham and Women's Hospital, USA
IL-18 Receptor is Required for Effector CD8+ T Cells to Survive the Contraction Phase of an Immune Response and Become Long-Lived Memory Cells
IL-18 Receptor is Required for Effector CD8+ T Cells to Survive the Contraction Phase of an Immune Response and Become Long-Lived Memory Cells
David Hildeman,
Cincinnati Children's Hospital, USA
Contraction of CD4+ T Cell Responses is not Controlled by Limiting Amounts of IL-7
Contraction of CD4+ T Cell Responses is not Controlled by Limiting Amounts of IL-7
Vilma Decman,
Bristol-Myers Squibb, USA
Qualitative Changes in Anti-Viral CD8 T Cell Responses with Aging
Qualitative Changes in Anti-Viral CD8 T Cell Responses with Aging
Susmit Suvas,
Oakland University, USA
Functional Significance of PD-1 Expression on Aging T Cells
Functional Significance of PD-1 Expression on Aging T Cells
Eric T. Clambey,
University of Colorado Denver, USA
Altered CD8 Memory T cells Homeostasis in Aging: Multiple Paths to CD8 Clonal Expansions
Altered CD8 Memory T cells Homeostasis in Aging: Multiple Paths to CD8 Clonal Expansions
17:00—19:00
Epigenetic and Transcriptional Regulation
*
Steven L. Reiner,
Columbia University, USA
Making Daughter T Cells Different During Immunity
Making Daughter T Cells Different During Immunity
Kathryn L. Calame,
Columbia College of Physicians and Surgeons, USA
Transcriptional Control in Memory for B and T Lymphocytes
Transcriptional Control in Memory for B and T Lymphocytes
Susan L. Swain,
University of Massachusetts Medical School, USA
Effector and Memory CD4 T Cell Protection in Influenza
Effector and Memory CD4 T Cell Protection in Influenza
Tania H. Watts,
University of Toronto, Canada
Short Talk: A Critical Role for TNFR Associated Factor 1 and Bim Down Regulation in CD8 Memory T Cell Survival
Short Talk: A Critical Role for TNFR Associated Factor 1 and Bim Down Regulation in CD8 Memory T Cell Survival
08:00—11:30
CD8+ T Cell Memory
Michael J. Bevan,
HHMI/University of Washington, USA
Role of CD4+ T Cells in Sustaining CD8+ T Cell Memory
Role of CD4+ T Cells in Sustaining CD8+ T Cell Memory
*
David L. Woodland,
Keystone Symposia on Molecular and Cellular Biology, USA
Heterogeneity of the Memory CD8+ T Cell Response to Respiratory Virus Infections
Heterogeneity of the Memory CD8+ T Cell Response to Respiratory Virus Infections
Ananda W. Goldrath,
University of California, San Diego, USA
Short Talk: A Novel Role for Id2 in the Regulation of CD8+ T Cell immunity
Short Talk: A Novel Role for Id2 in the Regulation of CD8+ T Cell immunity
Susan M. Kaech,
The Salk Institute, USA
Regulation of Memory CD8 T Cell Precursor Formation by T-bet and Inflammatory Cytokines
Regulation of Memory CD8 T Cell Precursor Formation by T-bet and Inflammatory Cytokines
Raymond M. Welsh,
University of Massachusetts Medical School, USA
Plasticity of CD8+ T Cell Responses following Heterologous Viral Infections
Plasticity of CD8+ T Cell Responses following Heterologous Viral Infections
Stephen P. Schoenberger,
La Jolla Institute for Allergy and Immunology, USA
Programming of CD8+ T Cell Responses: Tune In, Turn On, or Drop Out
Programming of CD8+ T Cell Responses: Tune In, Turn On, or Drop Out
14:30—16:30
Workshop 3: Animal Models of Vaccines
*
Dan H. Barouch,
Beth Israel Deaconess Medical Center, USA
Ross M. Kedl,
University of Colorado Denver, USA
Combined-TLR/CD40 Immunization Generates, and Rescues, CD4-Independent CD8+ T Cell Memory
Combined-TLR/CD40 Immunization Generates, and Rescues, CD4-Independent CD8+ T Cell Memory
Pratima Krishna-Suvas,
University of Tennessee, USA
Generation and Maintenance of Antigen-specific CD8 T Cells in the Vaginal Mucosa following Systemic versus Mucosal Routes of Immunization
Generation and Maintenance of Antigen-specific CD8 T Cells in the Vaginal Mucosa following Systemic versus Mucosal Routes of Immunization
Tara Marlene Strutt,
University of Central Florida, USA
Heterosubtypic CD4 and CD8 T cell Immunity Induced by CAV A/Alaska Protects Against the Inflammatory Cell Influx Associated with Lethal Virus Challenge
Heterosubtypic CD4 and CD8 T cell Immunity Induced by CAV A/Alaska Protects Against the Inflammatory Cell Influx Associated with Lethal Virus Challenge
Denise Y. L. Teoh,
SERC, A*STAR, Singapore
Programming CD8 T cells: Impact of immunization route on development of the CD8 T cell response and protective immunity
Programming CD8 T cells: Impact of immunization route on development of the CD8 T cell response and protective immunity
Gabrielle T. Belz,
Walter and Eliza Hall Institute of Medical Research, Australia
Optimal Expansion of Naïve and Memory CD8+ Cells in vivo Regulated by Divergent Mechanisms
Optimal Expansion of Naïve and Memory CD8+ Cells in vivo Regulated by Divergent Mechanisms
17:00—19:15
Regulatory Aspects of Memory Immunity
*
Harald von Boehmer,
Harvard Medical School, USA
Treg Induction and T Cell Memory
Treg Induction and T Cell Memory
Yiping Yang,
Duke University Medical Center, USA
Short Talk: The Development and Function of “Memory” Regulatory T Cells Following Viral Infection
Short Talk: The Development and Function of “Memory” Regulatory T Cells Following Viral Infection
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Influence of CD25+ Regulatory T Cells on Th1 Immunity
Influence of CD25+ Regulatory T Cells on Th1 Immunity
Linda M. Bradley,
Sanford-Burnham Medical Research Institute, USA
Short Talk: CD44 Regulates Effector Cell Survival and the Generation of Memory in CD4 Cells
Short Talk: CD44 Regulates Effector Cell Survival and the Generation of Memory in CD4 Cells
Richard J. Hodes,
NIA, National Institutes of Health, USA
Aging and the Immune System: Discoveries and Challenges
Aging and the Immune System: Discoveries and Challenges
08:00—11:15
Homeostasis and Memory
*
Philippa C. Marrack,
HHMI/National Jewish Health, USA
Viral Proteins which Interfere with Lymphocyte Death
Viral Proteins which Interfere with Lymphocyte Death
John T. Harty,
University of Iowa, USA
Querying the CD8 T cell Response Program
Querying the CD8 T cell Response Program
Leo Lefrançois,
University of Connecticut Health Center, USA
Imaging the Endogenous T Cell Response to Infection
Imaging the Endogenous T Cell Response to Infection
Benedita Rocha,
INSERM U591, France
The Analysis of of Single-Cells in CD8 Responses Reveals a Complex Effector Gene Expression with the Generation of Three Different Effector Types
The Analysis of of Single-Cells in CD8 Responses Reveals a Complex Effector Gene Expression with the Generation of Three Different Effector Types
Stephen C. Jameson,
University of Minnesota Medical School, USA
Helping Homeostatic Memory CD8 T cells
Helping Homeostatic Memory CD8 T cells
14:30—16:30
Workshop 4: T Cell Immunity and Chronic Infection
*
Louis J. Picker,
Oregon Health & Science University, USA
Title to be Determined
Title to be Determined
John F. McDyer,
John Hopkins University, USA
Acquisition of CMV-specific Effector T Cell Memory in the Airways and Blood During Primary Infection in Lung Transplant Recipients
Acquisition of CMV-specific Effector T Cell Memory in the Airways and Blood During Primary Infection in Lung Transplant Recipients
Lydie Trautmann,
US Military HIV Research Program, USA
Upregulation of PD-1 Expression in HIV Specific CD8 T Cells Leads to Reversible Functional Exhaustion
Upregulation of PD-1 Expression in HIV Specific CD8 T Cells Leads to Reversible Functional Exhaustion
Angela Shaulov Kask,
University of Washington, USA
Sustained Expansion of CD8 T Cells Requires Simultaneous Exposure to Antigen and Inflammation in vivo
Sustained Expansion of CD8 T Cells Requires Simultaneous Exposure to Antigen and Inflammation in vivo
Vandana Kalia,
Seattle Children's, USA
Mechanisms Regulating Memory CD8 T Cell Differentiation
Mechanisms Regulating Memory CD8 T Cell Differentiation
Kathy Cho,
Astellas Pharma US, USA
Determining the Role of Murine Cytomegalovirus (MCMV) Viral Activity in CD8+ T Cell Memory Inflation and Tem Phenotype during Latent Infection
Determining the Role of Murine Cytomegalovirus (MCMV) Viral Activity in CD8+ T Cell Memory Inflation and Tem Phenotype during Latent Infection
Kathleen Anderson,
Columbus Children's Hospital, USA
Persistent Viral Infection Results in a Delayed and Dysfunctional Memory CD4+ T Cell Response
Persistent Viral Infection Results in a Delayed and Dysfunctional Memory CD4+ T Cell Response
John R. Teijaro,
The Scripps Research Institute, USA
Distinct Protective Capacities of Lymphoid and Non-Lymphoid Memory CD4 T Cell to Influenza Challenge
Distinct Protective Capacities of Lymphoid and Non-Lymphoid Memory CD4 T Cell to Influenza Challenge
17:00—19:00
Vaccination
Rafi Ahmed,
Emory University School of Medicine, USA
Immunological Strategies for Treating Chronic Infections
Immunological Strategies for Treating Chronic Infections
*
Richard A. Koup,
NIAID, National Institutes of Health, USA
Prime-Boost Vaccination Against HIV Infection
Prime-Boost Vaccination Against HIV Infection
*Session Chair †Invited, not yet responded.
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