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This meeting took place in 2007
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Cell Signaling and Proteomics (X6)
Organizer(s) John R. Yates III, Steven P. Gygi and Lewis C. Cantley
March 22—27, 2007
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 22, 2006
Late Abstract Deadline: Dec 21, 2006
Scholarship Deadline: Nov 22, 2006
Early Registration Deadline: Jan 23, 2007
Supported by the Director's Fund
Joint Meeting:
Systems Biology and Regulatory Networks (X5)
Summary of Meeting:
Cell signaling is an essential physiological function in cells and developing a complete understanding of signaling pathways, networks and interactions is a major challenge in the field. The objective of this meeting is to combine cell signaling issues--frontiers, challenges, unanswered questions--with discussions of proteomic technology status and future directions related to challenges in the signaling area. In essence the meeting will provide an update on the current status of signaling research and proteomics technology with a dialogue between signaling researchers and proteomic technology developers. From this dialogue, we anticipate new directions in signaling and proteomics research and new collaborations and interactions that will push the frontiers of signaling research.
View Scholarships/Awards
Cell signaling is an essential physiological function in cells and developing a complete understanding of signaling pathways, networks and interactions is a major challenge in the field. The objective of this meeting is to combine cell signaling issues--frontiers, challenges, unanswered questions--with discussions of proteomic technology status and future directions related to challenges in the signaling area. In essence the meeting will provide an update on the current status of signaling research and proteomics technology with a dialogue between signaling researchers and proteomic technology developers. From this dialogue, we anticipate new directions in signaling and proteomics research and new collaborations and interactions that will push the frontiers of signaling research.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
THURSDAY, MARCH 22
FRIDAY, MARCH 23
SATURDAY, MARCH 24
SUNDAY, MARCH 25
MONDAY, MARCH 26
TUESDAY, MARCH 27
Conference Program Print | View meeting in 12 hr (am/pm) time
THURSDAY, MARCH 22
19:30—21:30
Keynote Session (Joint)
*
John R. Yates III,
The Scripps Research Institute, USA
Donald F. Hunt,
University of Virginia, USA
Innovative Technology for the Study of Cell Signaling
Innovative Technology for the Study of Cell Signaling
Lucy Shapiro,
Stanford University, USA
Spatial and Temporal Components of the Bacterial Cell Cycle Genetic Circuitry
Spatial and Temporal Components of the Bacterial Cell Cycle Genetic Circuitry
08:00—11:00
Frontiers and Challenges in Signaling I
*
Michael J. Weber,
University of Virginia, USA
Tony Hunter,
The Salk Institute for Biological Sciences, USA
Kinomics: Challenges for the Future
Kinomics: Challenges for the Future
Lewis C. Cantley,
Weill Cornell Medicine, USA
The Role of Phosphorylation in Signaling
The Role of Phosphorylation in Signaling
Joris Benschop,
University Medical Center Utrecht, Netherlands
Short Talk: Post-Translational Regulation of the Yeast Mediator Complex
Short Talk: Post-Translational Regulation of the Yeast Mediator Complex
Karl R. Clauser,
Broad Institute of Massachusetts Institute of Technology, Harvard, USA
Short Talk: Phosphoproteomic Screen Defines Polo-Box Domain Mitotic Interactome and Identifies the Cytokinesis Regulator Rho-Associated Kinase-2 as a Plk1 Substrate
Short Talk: Phosphoproteomic Screen Defines Polo-Box Domain Mitotic Interactome and Identifies the Cytokinesis Regulator Rho-Associated Kinase-2 as a Plk1 Substrate
08:00—11:15
Transcriptional Regulatory Networks
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Regulatory Circuitry of Human Embryonic Stem Cells
Regulatory Circuitry of Human Embryonic Stem Cells
Aviv Regev,
Massachusetts Institute of Technology, USA
Natural History and Evolutionary Principles of Gene Duplication in Fungi
Natural History and Evolutionary Principles of Gene Duplication in Fungi
Alexander D. Johnson,
University of California, San Francisco, USA
Evolution of Transcriptional Curcuits
Evolution of Transcriptional Curcuits
*
Gloria M. Coruzzi,
New York University, USA
A Systems Approach to Nitrogen Networks and the “VirtualPlant”
A Systems Approach to Nitrogen Networks and the “VirtualPlant”
Mark D. Biggin,
Lawrence Berkeley National Laboratory, USA
Short Talk: Berkeley Drosophlia Transcription Network Project
Short Talk: Berkeley Drosophlia Transcription Network Project
Andrea Califano,
Columbia University, USA
Short Talk: Genome-Wide Discovery of Post-Translational Modulators of Transcriptional Interactions in Human B Lymphocytes
Short Talk: Genome-Wide Discovery of Post-Translational Modulators of Transcriptional Interactions in Human B Lymphocytes
17:00—19:00
Posttranslational Networks (Joint)
Steven P. Gygi,
Harvard Medical School, USA
Measuring Changes In Protein Phosphorylation State On A Proteome Scale
Measuring Changes In Protein Phosphorylation State On A Proteome Scale
*
Tony Pawson,
Samuel Lunenfeld Research Institute, Canada
Interaction Domains in Cellular Regulation
Interaction Domains in Cellular Regulation
08:00—11:00
Frontiers and Challenges in Signaling II
*
Lewis C. Cantley,
Weill Cornell Medicine, USA
Tania A. Baker,
Massachusetts Institute of Technology, USA
Recognition Logic of the AAA+ Protein Unfolding ATPases
Recognition Logic of the AAA+ Protein Unfolding ATPases
Michael J. Weber,
University of Virginia, USA
Cell Signaling by the Erk Pathway
Cell Signaling by the Erk Pathway
James A. Wells,
University of California, San Francisco, USA
Degradomics: The Proteolysis of Cell Death
Degradomics: The Proteolysis of Cell Death
Marcus Smolka,
Weill Institute for Cell and Molecular Biology , Cornell University, USA
Short Talk: Mapping the DNA Damage Signaling Network by a Global and Quantitative Phosphorylation Analysis
Short Talk: Mapping the DNA Damage Signaling Network by a Global and Quantitative Phosphorylation Analysis
Joshua E. Elias,
Harvard Medical School, USA
Short Talk: Progress Towards Global Measurements of Protein Degradation in Cultured Steady-State Cells by Quantitative Mass Spectrometry
Short Talk: Progress Towards Global Measurements of Protein Degradation in Cultured Steady-State Cells by Quantitative Mass Spectrometry
08:00—11:15
Complex Systems I
*
Susan K. Dutcher,
Washington University School of Medicine, USA
Comparative Genomic Analysis of Chlamydomonas Flagella and Insight into Human Disease
Comparative Genomic Analysis of Chlamydomonas Flagella and Insight into Human Disease
Phillippe Cluzel,
University of Chicago, USA
Inferring Cellular Response from Behavioral Variability in a Simple Signal Transduction Network
Inferring Cellular Response from Behavioral Variability in a Simple Signal Transduction Network
Christopher J. Bakal,
Institute of Cancer Research, UK
Short Talk: Genetically Identical Cells can Adopt a Wide Variety of Shapes
Short Talk: Genetically Identical Cells can Adopt a Wide Variety of Shapes
Rodney J. Rothstein,
Columbia University Medical Center, USA
Short Talk: Taking a Global Approach to Explore how Cells Respond to DNA Damage
Short Talk: Taking a Global Approach to Explore how Cells Respond to DNA Damage
17:00—19:00
Phosphorylation Profiling I
Joshua J. Coon,
University of Wisconsin, USA
Tracking Kinase Signaling Cascades in Human Embryonic Stem Cells
Tracking Kinase Signaling Cascades in Human Embryonic Stem Cells
Peipei Ping,
University of California, Los Angeles, USA
Regulation of Cardiac 20S Proteasome Complexes by Associating Partners
Regulation of Cardiac 20S Proteasome Complexes by Associating Partners
Cristian I. Ruse,
The Scripps Research Institute, USA
Barium Precipitation for Phosphopeptide Profiling
Barium Precipitation for Phosphopeptide Profiling
17:00—19:00
Complex Systems II
Jack F. Greenblatt,
University of Toronto, Canada
Protein and Genetic Interaction Networks for Pathway Elucidation
Protein and Genetic Interaction Networks for Pathway Elucidation
*
Thomas R. Gingeras,
Cold Spring Harbor Laboratory, USA
Transcriptional Landscape of the Human Genome: Same Genomic Locus-Multiple Functional Transcripts
Transcriptional Landscape of the Human Genome: Same Genomic Locus-Multiple Functional Transcripts
Yijun Ruan,
The Jackson Laboratory for Genomic Medicine, USA
Short Talk: Whole Genome Chromatin Interaction Analysis using Paired End diTag (CIA-PET) to Study Transcription Regulation in Cancer Cells
Short Talk: Whole Genome Chromatin Interaction Analysis using Paired End diTag (CIA-PET) to Study Transcription Regulation in Cancer Cells
08:00—11:00
Frontiers and Challenges in Signaling III
*
Peipei Ping,
University of California, Los Angeles, USA
J. Wade Harper,
Harvard Medical School, USA
Control of Signaling Systems through the Ubiquitin Proteasome Pathway
Control of Signaling Systems through the Ubiquitin Proteasome Pathway
Thibault Mayor,
University of British Columbia, Canada
Profiling of Ubiquitylated Proteins using Quantitative Mass Spectrometry to Reveal Proteasome Substrates and Rpn10 Receptor Repertoire
Profiling of Ubiquitylated Proteins using Quantitative Mass Spectrometry to Reveal Proteasome Substrates and Rpn10 Receptor Repertoire
Dorothea Fiedler,
Princeton University, USA
Short Talk: An E-MAP of Kinase and Phosphatase Signaling in Saccharomyces cerevisiae
Short Talk: An E-MAP of Kinase and Phosphatase Signaling in Saccharomyces cerevisiae
Adam Friedman,
Oncology NewCo, USA
Short Talk: Functional Genomic Screens for Novel Regulators of Receptor Tyrosine Kinase and ERK Signaling Specificity
Short Talk: Functional Genomic Screens for Novel Regulators of Receptor Tyrosine Kinase and ERK Signaling Specificity
08:00—11:15
Posttranscriptional Regulatory Networks
David P. Bartel,
Massachusetts Institute of Technology and Whitehead Institute, USA
Global Analysis of microRNAs
Global Analysis of microRNAs
*
Gisela T. Storz,
National Institutes of Health, USA
Wide Ranging Functions of Small RNAs in Bacteria
Wide Ranging Functions of Small RNAs in Bacteria
Kimberly C. Tu,
University of Utah, USA
Short Talk: Multiple Small RNAs Act Additively to Integrate Sensory Information and Control Quorum Sensing in Vibrio Harveyi
Short Talk: Multiple Small RNAs Act Additively to Integrate Sensory Information and Control Quorum Sensing in Vibrio Harveyi
Manolis Kellis,
Massachusetts Institute of Technology, Broad Institute, USA
Short Talk: Regulatory Networks in 12 Drosophila genomes
Short Talk: Regulatory Networks in 12 Drosophila genomes
17:00—19:00
Cascades Controlling Developmental Fates (Joint)
Ronald M. Evans,
HHMI/The Salk Institute, USA
Nuclear Receptors: Metabolic Engineering and the Dawn of Synthetic Physiology - Balancing the Fat Equation
Nuclear Receptors: Metabolic Engineering and the Dawn of Synthetic Physiology - Balancing the Fat Equation
Ulrike Gaul,
Rockefeller University, USA
Decoding Transcription Control in Drosophila Segmentation
Decoding Transcription Control in Drosophila Segmentation
*
Roger Brent,
Molecular Sciences Institute, USA
Physiology and Genetic Regulation of Cellular Signal Transmission
Physiology and Genetic Regulation of Cellular Signal Transmission
08:00—11:00
Microarray Technology for Signaling
Speaker to be Announced
Rudolf H. Aebersold,
Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Topology and Dynamics of Protein Interaction Networks
Topology and Dynamics of Protein Interaction Networks
Lawrence E. Goldfinger,
University of California, San Diego, USA
Short Talk: Discovering Novel Ras Effectors in Cell Migration
Short Talk: Discovering Novel Ras Effectors in Cell Migration
Neil E. Olszewski,
University of Minnesota, USA
Short Talk: Determining the Function of O-GlcNAc Modification in Signaling Pathways of Plants
Short Talk: Determining the Function of O-GlcNAc Modification in Signaling Pathways of Plants
Rune Linding,
University of Copenhagen, Denmark
Short Talk: Systematic Discovery of In Vivo Phosphorylation Networks
Short Talk: Systematic Discovery of In Vivo Phosphorylation Networks
08:00—11:00
Systems Analysis of Disease
Vamsi K. Mootha,
Massachusetts General Hospital, USA
Systems Analysis of Human Mitochondrial Disorders
Systems Analysis of Human Mitochondrial Disorders
Brenda J. Andrews,
University of Toronto, Canada
Systematic Yeast Genetics to Explore Biological Pathways and Kinase Targets
Systematic Yeast Genetics to Explore Biological Pathways and Kinase Targets
Maureen E. Hillenmeyer,
Stanford University, USA
Short Talk: The Chemical Genomic Portrait of the Cell Reveals a Phenotype for all Yeast Cells
Short Talk: The Chemical Genomic Portrait of the Cell Reveals a Phenotype for all Yeast Cells
*
Garry P. Nolan,
Stanford University, USA
Mechanistic Insights from the Single Cell: Inference Engines for Signaling with Clinical Samlpes
Mechanistic Insights from the Single Cell: Inference Engines for Signaling with Clinical Samlpes
Andrea H. Bild,
City of Hope Comprehensive Cancer Institute, USA
Short Talk: Unique Patterns of Pathway Deregulation and Chemotherapeutic Responses in Breast Cancer Subtypes
Short Talk: Unique Patterns of Pathway Deregulation and Chemotherapeutic Responses in Breast Cancer Subtypes
Thomas G. Graeber,
University of California, Los Angeles, USA
Short Talk: Phosphoproteome Analysis of Drug-Resistant BCR-ABL Mutants Reveals Mutant-Specific Global Signaling Patterns and BCR-ABL ATP Binding Loop Phosphorylation Pattern-Based Determinants of Oncogenicity
Short Talk: Phosphoproteome Analysis of Drug-Resistant BCR-ABL Mutants Reveals Mutant-Specific Global Signaling Patterns and BCR-ABL ATP Binding Loop Phosphorylation Pattern-Based Determinants of Oncogenicity
17:00—19:00
Phosphorylation Profiling II
Benjamin A. Garcia,
University of Pennsylvania, USA
Top Down Protein Analysis to Identify PTMs
Top Down Protein Analysis to Identify PTMs
Forest M. White,
Massachusetts Institute of Technology, USA
Quantitative Analysis of ErbB Cellular Signaling Networks
Quantitative Analysis of ErbB Cellular Signaling Networks
17:00—19:00
Integrative Networks
Aimee Dudley,
Institute for Systems Biology, USA
Analysis of Individual Expression Variation Reveals a Post Transcriptional Network
Analysis of Individual Expression Variation Reveals a Post Transcriptional Network
*
Audrey P. Gasch,
University of Wisconsin-Madison, USA
Integrative Signaling Networks in the Regulation of Stress-Dependent Geomic Expression in Yeast
Integrative Signaling Networks in the Regulation of Stress-Dependent Geomic Expression in Yeast
Edward M. Marcotte,
University of Texas at Austin, USA
Steps toward Directed Identification of Disease Genes: Rational Prediction of Loss of Function Phenotypes
Steps toward Directed Identification of Disease Genes: Rational Prediction of Loss of Function Phenotypes
Leroy E. Hood,
Institute for Systems Biology, USA
A Systems Approach to Disease: Predictive and Preventive Medicine
A Systems Approach to Disease: Predictive and Preventive Medicine
*Session Chair †Invited, not yet responded.
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