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This meeting took place in 2008
Here are the related meetings in 2021:
Cancer Stem Cells: Advances in Biology and Clinical Translation (EK46)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Stem Cells, Cancer and Aging (S3)
Organizer(s) Sir David P. Lane, Hans C. Clevers, Arnold J. Levine and Xin Lu
September 29—October 4, 2008
Swissotel The Stamford • Singapore, Singapore
Abstract Deadline: May 29, 2008
Late Abstract Deadline: Jun 30, 2008
Scholarship Deadline: Jun 12, 2008
Early Registration Deadline: Jul 29, 2008
In collaboration with Agency for Science, Technology and Research (A*STAR) and held in conjunction with the International Society of Differentiation. Sponsored by Lilly Singapore Centre for Drug Discovery.
Summary of Meeting:
Recent studies on the effect of polymorphisms in human tumor suppressor pathways on cancer incidence and longevity have confirmed long held views of the link between the key processes that control human aging and cancer incidence. One interpretation of these findings is that the stem cell is the key target for carcinogenesis. Further, the thresholds that regulate stem cell death in response to damage make the bargain between too-resilient stem cells, which result in long life but increased cancer risk, and too-sensitive stem cells, which ablate the occurrence of cancer but can shorten life span through stem cell exhaustion. Dramatic progress in the understanding of signaling pathways and points of intervention which will be debated in this meeting offers the enticing prospect of regulating these pathways to extend healthy lifespan and reduce cancer incidence in the human population.
View Scholarships/Awards
Recent studies on the effect of polymorphisms in human tumor suppressor pathways on cancer incidence and longevity have confirmed long held views of the link between the key processes that control human aging and cancer incidence. One interpretation of these findings is that the stem cell is the key target for carcinogenesis. Further, the thresholds that regulate stem cell death in response to damage make the bargain between too-resilient stem cells, which result in long life but increased cancer risk, and too-sensitive stem cells, which ablate the occurrence of cancer but can shorten life span through stem cell exhaustion. Dramatic progress in the understanding of signaling pathways and points of intervention which will be debated in this meeting offers the enticing prospect of regulating these pathways to extend healthy lifespan and reduce cancer incidence in the human population.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
MONDAY, SEPTEMBER 29
TUESDAY, SEPTEMBER 30
WEDNESDAY, OCTOBER 1
THURSDAY, OCTOBER 2
FRIDAY, OCTOBER 3
SATURDAY, OCTOBER 4
Conference Program Print | View meeting in 12 hr (am/pm) time
MONDAY, SEPTEMBER 29
08:00—08:15
Welcoming Remarks
Lim Chuan Poh,
Agency for Science, Technology and Research (A*STAR), Singapore
08:15—08:30
Opening Remarks
David P. Lane,
Agency for Science, Technology and Research, Singapore
08:30—12:00
Models of Aging
*
David P. Lane,
Agency for Science, Technology and Research, Singapore
Jan H. J. Hoeijmakers,
Erasmus MC, Netherlands
DNA Repair and the Connection between Cancer and Aging
DNA Repair and the Connection between Cancer and Aging
Lawrence A. Donehower,
Baylor College of Medicine, USA
Insights into Stem Cells and Aging Provided by A P53 Mutant Mouse
Insights into Stem Cells and Aging Provided by A P53 Mutant Mouse
Mary Ellen Perry,
DPCPSI, OD, National Institutes of Health, USA
p53 and Aging in Experimental Animals
p53 and Aging in Experimental Animals
13:00—14:00
ISD Award Lecture: Anne McLaren Memorial Lecturer
Magdalena D. Zernicka-Goetz,
Caltech and University of Cambridge, UK
Cell Fate, Plasticity and Pluripotency in the Early Mouse embryo
Cell Fate, Plasticity and Pluripotency in the Early Mouse embryo
14:30—16:00
Regulating Tumor Suppression
Gerard I. Evan,
University of Cambridge, UK
Switchable Tumor Suppression Models to Control Cancer and Aging
Switchable Tumor Suppression Models to Control Cancer and Aging
Alea A. Mills,
Cold Spring Harbor Laboratory, USA
p63 Deficiency and Aging
p63 Deficiency and Aging
08:00—11:30
Signaling Pathways in Cancer and Development
Hans C. Clevers,
Hubrecht Institute, Netherlands
Identification of Stem Cells in Small Intestine and Colon by a Single Marker Gene LGR5
Identification of Stem Cells in Small Intestine and Colon by a Single Marker Gene LGR5
Yoshiaki Ito,
National University of Singapore, Singapore
RUNX3, a Novel Gate Keeper of Colon Carcinogenesis
RUNX3, a Novel Gate Keeper of Colon Carcinogenesis
Vinay B. Tergaonkar,
Institute of Molecular and Cell Biology, Singapore
New Controls of the NF-kappa B Pathway
New Controls of the NF-kappa B Pathway
Michael Karin,
University of California, San Diego, USA
Inflammatory Processes in Metastatic Progression
Inflammatory Processes in Metastatic Progression
14:30—16:30
Counting Stem Cells
*
Gerard I. Evan,
University of Cambridge, UK
Connie J. Eaves,
British Columbia Cancer Agency, Canada
Title to be Determined
Title to be Determined
Hongyan Wang,
Duke NUS-Graduate Medical School Singapore, Singapore
Short Talk: Brain Tumor Suppressors and Neural Stem Cell Self-Renewal in Drosophila
Short Talk: Brain Tumor Suppressors and Neural Stem Cell Self-Renewal in Drosophila
08:00—09:00
Keynote Address
Arnold J. Levine,
Institute for Advanced Study, USA
Single Nucleotide Polymorphisms in the p53 Pathway
Single Nucleotide Polymorphisms in the p53 Pathway
09:00—11:30
New Models to Find Novel Cancer and Aging Pathways
*
Arnold J. Levine,
Institute for Advanced Study, USA
Xin Lu,
Ludwig Institute for Cancer Research, UK
ASPP2 Mediates Senescence and Inhibits Autophagy and Tumourgenicity Induced by H-RasV12
ASPP2 Mediates Senescence and Inhibits Autophagy and Tumourgenicity Induced by H-RasV12
Neal G. Copeland,
Institute of Molecular and Cell Biology, Singapore
Harnessing Transposons for Cancer Gene Discovery
Harnessing Transposons for Cancer Gene Discovery
Edison T. Liu,
The Jackson Laboratory, USA
Comprehensive Identification of Genomic Rearrangements in Human Cancer
Comprehensive Identification of Genomic Rearrangements in Human Cancer
14:30—16:30
New Targets and Therapeutic Approaches to Cancer and Aging
*
Xin Lu,
Ludwig Institute for Cancer Research, UK
David P. Lane,
Agency for Science, Technology and Research, Singapore
Small Molecule Switches to Control p53 Activity
Small Molecule Switches to Control p53 Activity
Axel Ullrich,
Max Planck Institute of Biochemistry, Germany
The Singapore OncoGenome Project as Part of an Effort to Develop a Portfolio of Targeted Cancer Therapeutics
The Singapore OncoGenome Project as Part of an Effort to Develop a Portfolio of Targeted Cancer Therapeutics
08:30—10:30
Cancer Stem Cells
*
Xin Lu,
Ludwig Institute for Cancer Research, UK
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
Cancer Stem Cells in the Hematopoietic System
Cancer Stem Cells in the Hematopoietic System
Colin L. Stewart,
Institute of Medical Biology, Singapore
The Lamins and the Functional Architecture of the Nucleus in Disease and Aging
The Lamins and the Functional Architecture of the Nucleus in Disease and Aging
Daniel G. Tenen,
Cancer Science Institute, Singapore
Transcription Factor C/EBP alpha Regulates Hematopoietic Stem Cell Proliferation and Maintenance during Aging
Transcription Factor C/EBP alpha Regulates Hematopoietic Stem Cell Proliferation and Maintenance during Aging
11:00—12:00
ISD Award Lecture: Jean Brachet Memorial Lecturer
15:00—16:45
More Adult Stem Cells in the Self-Renewing Tissues
Davor Solter,
Institute of Medical Biology, Singapore
Preformation Versus Epigenesis in Driving Mammalian Development
Preformation Versus Epigenesis in Driving Mammalian Development
Jean-Paul Thiery,
Institute of Molecular and Cellular Biology, Singapore
Potentiality of Mammary Epithelial Cells with a Basal Phenotype
Potentiality of Mammary Epithelial Cells with a Basal Phenotype
16:45—17:00
Meeting Sum Up
Xin Lu,
Ludwig Institute for Cancer Research, UK
Arnold J. Levine,
Institute for Advanced Study, USA
*Session Chair †Invited, not yet responded.
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