Fairmont Hotel Vancouver Floorplan

Registered Attendees
Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:
- Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting
(You can edit your own abstract from My Account page as well)
NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.
- Full participant list, including joint meeting participants
- Printable Invoices and Invitation Letters
- Scholarship Information
- Lodging Information
Login to My Account page
This meeting took place in 2008
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Molecular, Cellular, Physiological, and Pathogenic Responses to Hypoxia (J6)
Organizer(s) Gregg L. Semenza, Nanduri R. Prabhakar and Lorenz Poellinger
January 15—20, 2008
Fairmont Hotel Vancouver • Vancouver, BC Canada
Abstract Deadline: Sep 17, 2007
Late Abstract Deadline: Oct 22, 2007
Scholarship Deadline: Sep 17, 2007
Early Registration Deadline: Nov 19, 2007
Supported by the Director's Fund
Summary of Meeting:
Oxygen is the substrate of multicellular life. Reduced oxygen availability (hypoxia) is sensed and transduced into changes in the activity or expression of cellular macromolecules. These responses impact on all areas of biology and medicine. The goals of the meeting are: • To understand the molecular mechanisms underlying responses to hypoxia that affect protein activity, protein synthesis, protein stability, mRNA synthesis, and mRNA stability, including the role of hypoxia-inducible factor 1 as a master regulator of oxygen homeostasis and its oxygen-dependent regulation by prolyl and asparaginyl hydroxylases. • To understand the role of hypoxia as a stimulus for normal developmental and physiological processes, including hypoxia-induced changes in vascularization. • To understand the role of hypoxia in the pathogenesis of common human diseases including cardiovascular disease, cancer, chronic lung disease, and diabetes, which account for the majority of deaths in developed countries. • The development of novel therapeutic strategies that target hypoxia response pathways.
View Scholarships/Awards
Oxygen is the substrate of multicellular life. Reduced oxygen availability (hypoxia) is sensed and transduced into changes in the activity or expression of cellular macromolecules. These responses impact on all areas of biology and medicine. The goals of the meeting are: • To understand the molecular mechanisms underlying responses to hypoxia that affect protein activity, protein synthesis, protein stability, mRNA synthesis, and mRNA stability, including the role of hypoxia-inducible factor 1 as a master regulator of oxygen homeostasis and its oxygen-dependent regulation by prolyl and asparaginyl hydroxylases. • To understand the role of hypoxia as a stimulus for normal developmental and physiological processes, including hypoxia-induced changes in vascularization. • To understand the role of hypoxia in the pathogenesis of common human diseases including cardiovascular disease, cancer, chronic lung disease, and diabetes, which account for the majority of deaths in developed countries. • The development of novel therapeutic strategies that target hypoxia response pathways.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, JANUARY 15
WEDNESDAY, JANUARY 16
THURSDAY, JANUARY 17
FRIDAY, JANUARY 18
SATURDAY, JANUARY 19
SUNDAY, JANUARY 20
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, JANUARY 15
19:30—21:30
Keynote Session (Joint)
Salvador Moncada,
University of Manchester, UK
Nitric Oxide and Oxygen Homeostasis
Nitric Oxide and Oxygen Homeostasis
08:00—11:00
Oxygen and Cells
*
Lorenz Poellinger,
Karolinska Institutet, Sweden
Sten Lindahl,
Karolinska Institutet, Sweden
Short Talk: Oxygen Biology: An Historical Perspective
Short Talk: Oxygen Biology: An Historical Perspective
Peter J. Ratcliffe,
University of Oxford, UK
Protein Hydroxylation and the Cellular Response to Hypoxia
Protein Hydroxylation and the Cellular Response to Hypoxia
Paul T. Schumacker,
Northwestern University, USA
Signaling by Mitochondrial Reactive Oxygen Species during Hypoxia
Signaling by Mitochondrial Reactive Oxygen Species during Hypoxia
Edward T.H. Yeh,
University of Texas MD Anderson Cancer Center, USA
Short Talk: SUMO-specific Protease 1 is Essential for Stabilization of HIF-1alpha during Hypoxia
Short Talk: SUMO-specific Protease 1 is Essential for Stabilization of HIF-1alpha during Hypoxia
Bradly G. Wouters,
University Health Network, Canada
Short Talk: Hypoxia Inhibits Disulfide Bond Formation and Protein Folding in the Endoplasmic Reticulum
Short Talk: Hypoxia Inhibits Disulfide Bond Formation and Protein Folding in the Endoplasmic Reticulum
Walter F. Boron,
Case Western Reserve University, USA
Gas Channels
Gas Channels
José López-Barneó,
University of Seville, Spain
Facilitated O2 Diffusion and O2 Regulated Ion Channels
Facilitated O2 Diffusion and O2 Regulated Ion Channels
08:00—11:00
Vascular Development
*
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
Brant M. Weinstein,
NICHD, National Institutes of Health, USA
Pathways for Arterial Specification in Zebrafish
Pathways for Arterial Specification in Zebrafish
Takashi Mikawa,
Cardiovascular Research Institute, University of California, San Francisco, USA
Control of Vessel Patterning by BMP Signaling
Control of Vessel Patterning by BMP Signaling
Robert Herpers,
Hubrecht Institute, Netherlands
Short Talk: Redundant Roles for sox7 and sox18 in Arteriovenous Specification in Zebrafish
Short Talk: Redundant Roles for sox7 and sox18 in Arteriovenous Specification in Zebrafish
14:30—16:30
Workshop 1: Neurophysiological Responses to Hypoxia
*
Jan-Marino Ramirez,
University of Chicago, USA
Ganesh K. Kumar,
University Of Chicago, USA
ROS Signaling Mediates Intermittent Hypoxia-Induced Neurotransmitter Synthesis Via Post-translational Modifications of Synthesizing Enzymes
ROS Signaling Mediates Intermittent Hypoxia-Induced Neurotransmitter Synthesis Via Post-translational Modifications of Synthesizing Enzymes
Stephen T. Brown,
McMaster University, Canada
Chronic Hypoxia Regulates Genes Important for Metabolism, Packaging, and Secretion of Catecholamines in an Immortalized Adrenomedullary Chromaffin Cell Line
Chronic Hypoxia Regulates Genes Important for Metabolism, Packaging, and Secretion of Catecholamines in an Immortalized Adrenomedullary Chromaffin Cell Line
Alfredo J. Garcia,
University of Chicago, USA
Redox State Modulates the Respiratory Rhythmogenesis in the Pre-Botzinger Complex
Redox State Modulates the Respiratory Rhythmogenesis in the Pre-Botzinger Complex
Jay B. Dean,
University of South Florida, USA
Hyperoxia Induces CA1 Hippocampal Redox Stress, Neural Plasticity, and Hyperexcitability in Rat Brain Slices
Hyperoxia Induces CA1 Hippocampal Redox Stress, Neural Plasticity, and Hyperexcitability in Rat Brain Slices
Thomas F. Floyd,
Stony Brook University, USA
Impact of Aging Upon Cerebral Hypoxia Sensing of Anemia
Impact of Aging Upon Cerebral Hypoxia Sensing of Anemia
Fei Meng†,
Birmingham University, UK
Hypoxia-induced Calcium Elevation in Human Embryonic Kidney Cells
Hypoxia-induced Calcium Elevation in Human Embryonic Kidney Cells
14:30—16:30
Workshop 1: Experimental Models of Angiogenesis
*
George E. Davis,
University of Missouri School of Medicine, USA
Jeffrey J. Essner,
Iowa State University, USA
Moesin is Required For VEGF-dependent Endothelial Tube Formation In Vivo
Moesin is Required For VEGF-dependent Endothelial Tube Formation In Vivo
Maria J. Machado,
INSERM U833, France
Longitudinal Analyses of Blind-Ended Vessel Permeability During Angiogenesis in vivo
Longitudinal Analyses of Blind-Ended Vessel Permeability During Angiogenesis in vivo
Jing Chen,
Boston Children's Hospital / Harvard Medical School, USA
Erythropoietin Prevents Pathologic Vessel Loss and Subsequent Proliferation in a Mouse Model of Oxygen-Induced Retinopathy
Erythropoietin Prevents Pathologic Vessel Loss and Subsequent Proliferation in a Mouse Model of Oxygen-Induced Retinopathy
Theresa T. Lu,
Hospital for Special Surgery/Weill Cornell Medicine, USA
Dendritic Cells Regulate Lymph Node Vascular Growth
Dendritic Cells Regulate Lymph Node Vascular Growth
Bruno Larrivée,
College de France, France
Activation of the UNC5B Receptor by Netrin-1 Inhibits Sprouting Angiogenesis
Activation of the UNC5B Receptor by Netrin-1 Inhibits Sprouting Angiogenesis
Ping Ao,
University of Washington, USA
Cancer Genesis and Progression as Dynamics in Functional Landscape of Endogenous Molecular-Cellular Network
Cancer Genesis and Progression as Dynamics in Functional Landscape of Endogenous Molecular-Cellular Network
17:00—19:00
Adaptive Responses to Hypoxia
Gregg L. Semenza,
Johns Hopkins University School of Medicine, USA
Role of Hypoxia-Inducible Factor 1 in Oxygen Homeostasis
Role of Hypoxia-Inducible Factor 1 in Oxygen Homeostasis
Joseph A. Garcia,
Columbia University Medical Center, USA
Molecular Mechanisms Underlying HIF-2 Selective Signal Transduction
Molecular Mechanisms Underlying HIF-2 Selective Signal Transduction
John G. Wood,
University of Kansas Medical Center, USA
Short Talk: Microvascular Acclimatization to Hypoxia
Short Talk: Microvascular Acclimatization to Hypoxia
Mircea Ivan,
Tufts-New England Medical Center, USA
Short Talk: A microRNA Component of the Hypoxia Response
Short Talk: A microRNA Component of the Hypoxia Response
Cynthia M. Beall,
Case Western Reserve University, USA
Contrasting Adaptations to Hypoxia by Andean, Tibetan and East African Populations
Contrasting Adaptations to Hypoxia by Andean, Tibetan and East African Populations
17:00—19:00
Endothelial Guidance and Signaling
Tuomas Tammela,
Koch Institute for Integrative Cancer Research at MIT, USA
Featured Speaker: "Next Generation of Vascular Biologists": VEGF-C/VEGFR-3 in Angiogenic Sprouting and Lymphatic Vessel Maturation
Featured Speaker: "Next Generation of Vascular Biologists": VEGF-C/VEGFR-3 in Angiogenic Sprouting and Lymphatic Vessel Maturation
Holger Gerhardt,
Max Delbrück Center for Molecular Medicine, Germany
Molecular Regulation of Endothelial Tip and Stalk Cells in Sprouting Angiogenesis
Molecular Regulation of Endothelial Tip and Stalk Cells in Sprouting Angiogenesis
Christiana Ruhrberg,
University College London, UK
Neuropilin Signalling in Neuronal and Vascular Development
Neuropilin Signalling in Neuronal and Vascular Development
Michael Potente,
Max Planck Institute for Heart and Lung Research, Germany
Short Talk: SIRT1 Regulates Endothelial Tip Cell Formation during Sprouting Angiogenesis
Short Talk: SIRT1 Regulates Endothelial Tip Cell Formation during Sprouting Angiogenesis
Michael Potente,
Max Planck Institute for Heart and Lung Research, Germany
Short Talk: SIRT1 Regulates Endothelial Tip Cell Formation during Sprouting Angiogenesis
Short Talk: SIRT1 Regulates Endothelial Tip Cell Formation during Sprouting Angiogenesis
08:00—11:00
Development and Differentiation
Guo-Hua Fong,
University of Connecticut Health Center, USA
Short Talk: The HIF-Specific Prolyl Hydroxylase PHD2 Protein may be Directly Required in the Vascular Endothelium to Prevent Excessive Angiogenesis in Mice
Short Talk: The HIF-Specific Prolyl Hydroxylase PHD2 Protein may be Directly Required in the Vascular Endothelium to Prevent Excessive Angiogenesis in Mice
Erinn B. Rankin,
Stanford University, USA
Short Talk: Hypoxia-Inducible Factor 2 Regulates VHL Associated Vascular Tumorigenesis and Hepatic Lipid Metabolism In Vivo
Short Talk: Hypoxia-Inducible Factor 2 Regulates VHL Associated Vascular Tumorigenesis and Hepatic Lipid Metabolism In Vivo
Susan Quaggin,
Northwestern University, USA
Podocyte-Endothelial Interactions and Angiogenic Factors in the Kidney
Podocyte-Endothelial Interactions and Angiogenic Factors in the Kidney
Ellen van Rooijen,
Hubrecht Institute, Developmental Biology and Stem Cell Research, Netherlands
Short Talk: The von Hippel-Lindau Tumor Suppressor Gene Ortholog vhl1 Regulates Zebrafish Hematopoiesis
Short Talk: The von Hippel-Lindau Tumor Suppressor Gene Ortholog vhl1 Regulates Zebrafish Hematopoiesis
Lorenz Poellinger,
Karolinska Institutet, Sweden
Oxygen-Dependent Regulation of Cellular Differentiation
Oxygen-Dependent Regulation of Cellular Differentiation
M. Celeste Simon,
University of Pennsylvania, USA
Hypoxia and Stem Cells
Hypoxia and Stem Cells
08:00—11:00
Angiogenesis in Disease & Tissue Maintenance
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
Hypoxia, Angiogenesis, Metabolism
Hypoxia, Angiogenesis, Metabolism
Gavin O. Thurston,
Regeneron Pharmaceuticals Inc., USA
Dll4-Notch Signaling in Angiogenesis
Dll4-Notch Signaling in Angiogenesis
Florian P. Limbourg,
Medizinische Hochschule Hannover, Germany
Short Talk: Notch Signaling in the Arterial Endothelium Determines Postnatal Arteriogenesis
Short Talk: Notch Signaling in the Arterial Endothelium Determines Postnatal Arteriogenesis
Donald M. McDonald,
University of California, San Francisco, USA
Endothelial-Pericyte Interactions in Angiogenic Blood Vessels
Endothelial-Pericyte Interactions in Angiogenic Blood Vessels
Charles A. Lambert,
Tour de Pathologie B23/3, Belgium
Short Talk: VEGF111, a New VEGF-A Isoform Induced by Genotoxic Agents: Resistance to Proteolytic Degradation and Effect on Heart Ischemia after Infarction in Mice
Short Talk: VEGF111, a New VEGF-A Isoform Induced by Genotoxic Agents: Resistance to Proteolytic Degradation and Effect on Heart Ischemia after Infarction in Mice
Jason U. Tilan,
Georgetown University, USA
Short Talk: The NPY-Y2 Receptor (R) System and Platelets are Important for Ischemic Angiogenesis.
Short Talk: The NPY-Y2 Receptor (R) System and Platelets are Important for Ischemic Angiogenesis.
14:30—16:30
Workshop 2: Animal Models
*
M. Celeste Simon,
University of Pennsylvania, USA
Xin Qi,
Stanford University School of Medicine, USA
The Complex of Protein Kinase C delta and c-Abl Communicates Endoplasmic Reticulum Stress to the Mitochondria; an Essential Step in the Subsequent Apoptosis
The Complex of Protein Kinase C delta and c-Abl Communicates Endoplasmic Reticulum Stress to the Mitochondria; an Essential Step in the Subsequent Apoptosis
Reiko Inagi,
University of Tokyo School of Medicine, Japan
Glyoxalase I Overexpression Lowers Oxidative Stress and Ameliorates Renal Ischemia-Reperfusion Injury in the Rat
Glyoxalase I Overexpression Lowers Oxidative Stress and Ameliorates Renal Ischemia-Reperfusion Injury in the Rat
Sunghee Cho,
Burke Medical Research Institute, USA
Hyperlipidemia Exacerbates Ischemic Brain Injury Via CD36-mediated Foam Cell Formation
Hyperlipidemia Exacerbates Ischemic Brain Injury Via CD36-mediated Foam Cell Formation
Gail Walkinshaw,
FibroGen, USA
Novel HIF Prolyl Hydroxylase Inhibitors are Neuroprotective in Both Permanent and Transient Rodent Models of Middle Cerebral Artery Occlusion
Novel HIF Prolyl Hydroxylase Inhibitors are Neuroprotective in Both Permanent and Transient Rodent Models of Middle Cerebral Artery Occlusion
Holger K. Eltzschig,
University of Texas Health Science Center at Houston, USA
Role of HIF-1alpha in A2B Adenosine Receptor-dependent Cardioprotection During Ischemic Preconditioning
Role of HIF-1alpha in A2B Adenosine Receptor-dependent Cardioprotection During Ischemic Preconditioning
Mikko A. I. Keränen,
University of Helsinki, Finland
Constitutively Expressed Hypoxia-Inducible Factor-1Ą Prevents the Development of Cardiac Allograft Vasculopathy in the Rat
Constitutively Expressed Hypoxia-Inducible Factor-1Ą Prevents the Development of Cardiac Allograft Vasculopathy in the Rat
Cormac Taylor,
University College Dublin, Ireland
The Hydroxylase Inhibitor DMOG is Protective in a Murine Model of Colitis
The Hydroxylase Inhibitor DMOG is Protective in a Murine Model of Colitis
14:30—16:30
Workshop 2: Stem Cells and Endothelial Progenitors
*
Karen K. Hirschi,
Yale University, USA
Jessica L. Dries,
East Carolina University, USA
Enhanced Post-MI Angiogenesis Protects Hearts of Mice Null for the Circadian Clock Gene mPer2
Enhanced Post-MI Angiogenesis Protects Hearts of Mice Null for the Circadian Clock Gene mPer2
Tatiana V. Byzova,
Cleveland Clinic Foundation, USA
Beta 3 Integrin Function on Bone Marrow-Derived Cells Determines the Course of Adaptive and Pathological Angiogenesis
Beta 3 Integrin Function on Bone Marrow-Derived Cells Determines the Course of Adaptive and Pathological Angiogenesis
Masamichi Eguchi,
Tukai University School of Medicine, Japan
Thrombopoietin (TPO) Contributes to Therapeutic Vasculogenesis through Promoting Mobilization and Survival of Endothelial Progenitor Cells (EPCs) via akt/mTOR/p70S6K Pathway
Thrombopoietin (TPO) Contributes to Therapeutic Vasculogenesis through Promoting Mobilization and Survival of Endothelial Progenitor Cells (EPCs) via akt/mTOR/p70S6K Pathway
Elazar Zelzer,
Weizmann Institute of Science, Israel
SOX9 Regulation of Vegf in the Developing Skeleton Regulates Early Limb Vasculature Patterning
SOX9 Regulation of Vegf in the Developing Skeleton Regulates Early Limb Vasculature Patterning
Priya Prahalad,
Georgetown University, USA
9-cis-Retinoic Acid Mediated Regulation of Vasculogenic Mimicry in Breast Cancer
9-cis-Retinoic Acid Mediated Regulation of Vasculogenic Mimicry in Breast Cancer
17:00—19:00
Metabolism
*
Chi Van Dang,
University of Pennsylvania, USA
Oxygen-Dependent Regulation of Glucose Metabolism and Oncogenesis: Interplay between MYC and HIF
Oxygen-Dependent Regulation of Glucose Metabolism and Oncogenesis: Interplay between MYC and HIF
Kathleen A. O'Hagan,
University College Dublin, Ireland
Short Talk: PGC-1alpha Induced Increase in Oxygen Consumption Leads to Activity of HIF Target Genes
Short Talk: PGC-1alpha Induced Increase in Oxygen Consumption Leads to Activity of HIF Target Genes
Julián Aragonés Lopez,
Research Institute Princesa, Spain
Short Talk: PHD1 Deficient Mice Lower Oxygen Consumption by Reprogramming Skeletal Muscle Glucose Metabolism via PPARA Transcription Factor
Short Talk: PHD1 Deficient Mice Lower Oxygen Consumption by Reprogramming Skeletal Muscle Glucose Metabolism via PPARA Transcription Factor
Robert T. Abraham,
Vividion Therapeutics, USA
Interplay between mTOR Signaling and Autophagy during Metabolic Stress in Human Cancer Cells
Interplay between mTOR Signaling and Autophagy during Metabolic Stress in Human Cancer Cells
Keith Laderoute,
SRI International, USA
5'-AMP-Activated Protein Kinase (AMPK): Overview and Relevance for Tumor Biology
5'-AMP-Activated Protein Kinase (AMPK): Overview and Relevance for Tumor Biology
17:00—19:00
Extracellular Matrix and Angiogenesis
*
Victoria L. Bautch,
University of North Carolina at Chapel Hill, USA
David A. Cheresh,
University of California, San Diego, USA
Chemical Disruption of B-RAF/C-RAF Dimerization Blocks Angiogenesis and Tumor Growth
Chemical Disruption of B-RAF/C-RAF Dimerization Blocks Angiogenesis and Tumor Growth
R. Andrea DeYoung,
University of California, Los Angeles, USA
Short Talk: An Essential Role for CCN2 in Skin Angiogenesis
Short Talk: An Essential Role for CCN2 in Skin Angiogenesis
08:00—11:00
Endothelial Progenitors, Ischemia and Cardiovascular Disease (Joint)
*
Mark W. Majesky,
University of North Carolina at Chapel Hill, USA
Eli Keshet,
Hebrew University, Israel
Angiogenic- and non-Angiogenic Roles of VEGF in Adult Organs
Angiogenic- and non-Angiogenic Roles of VEGF in Adult Organs
Maria B. Grant,
University of Florida, USA
IGF Binding Protein-3 Regulates Hematopoietic Stem Cell and Endothelial Precursor Cell Function During Vascular Development
IGF Binding Protein-3 Regulates Hematopoietic Stem Cell and Endothelial Precursor Cell Function During Vascular Development
Vivek Mittal,
Weill Cornell Medical College, USA
Bone Marrow-Derived Endothelial Progenitor Cells Regulate the Angiogenic Switch in Tumor Growth and Metastasis
Bone Marrow-Derived Endothelial Progenitor Cells Regulate the Angiogenic Switch in Tumor Growth and Metastasis
Stefanie Dimmeler,
University of Frankfurt, Germany
Bone Marrow Progenitor Cell Therapy for Myocardial Infarction
Bone Marrow Progenitor Cell Therapy for Myocardial Infarction
17:00—19:00
ROS and Redox
*
Nanduri R. Prabhakar,
University of Chicago, USA
Responses to Intermittent Hypoxia: Consequences of Altered Red-Ox Homeostasis?
Responses to Intermittent Hypoxia: Consequences of Altered Red-Ox Homeostasis?
Stephen L. Archer,
Queen's University, Canada
Metabolic-Electric Signaling in the Pulmonary Circulation - The Interface Between Oxygen Sensing, Pulmonary Hypertension and Cancer
Metabolic-Electric Signaling in the Pulmonary Circulation - The Interface Between Oxygen Sensing, Pulmonary Hypertension and Cancer
Kay F. Macleod,
University of Chicago, USA
Short Talk: Regulation of Mitochondrial Integrity, Autophagy, and Cell Survival by BNIP3
Short Talk: Regulation of Mitochondrial Integrity, Autophagy, and Cell Survival by BNIP3
Masayuki Yamamoto,
Tohoku University Graduate School of Medicine, Japan
Protective Responses to Oxidant Stress
Protective Responses to Oxidant Stress
17:00—19:00
Vascular Growth, Assembly, and Polarity
*
Eli Keshet,
Hebrew University, Israel
Mark A. Krasnow,
Stanford University School of Medicine, USA
Genetic Dissection of Tube Formation and Branching
Genetic Dissection of Tube Formation and Branching
George E. Davis,
University of Missouri School of Medicine, USA
Molecular Control of Endothelial Lumen Formation
Molecular Control of Endothelial Lumen Formation
Victoria L. Bautch,
University of North Carolina at Chapel Hill, USA
Integrating Cell Division and Vascular Morphogenesis
Integrating Cell Division and Vascular Morphogenesis
Hiroyasu Kidoya,
Research Institute for Microbial Diseases, Osaka University, Japan
Short Talk: Apelin, as an Induction Factor for Neovascular Maturation
Short Talk: Apelin, as an Induction Factor for Neovascular Maturation
08:00—11:00
Cancer
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
The VHL Gene: Oxygen Sensing and Cancer
The VHL Gene: Oxygen Sensing and Cancer
Poul H. B. Sorensen,
University of British Columbia, Canada
Short Talk: A Novel E3 Ubiquitin Ligase HACE1 Represses HIF-1alpha Accumulation Under Hypoxic Conditions
Short Talk: A Novel E3 Ubiquitin Ligase HACE1 Represses HIF-1alpha Accumulation Under Hypoxic Conditions
Amato J. Giaccia,
Stanford University, USA
Hypoxia Induced Gene Expression in Cancer Cells
Hypoxia Induced Gene Expression in Cancer Cells
Erwin G. Van Meir,
Emory University School of Medicine, USA
Short Talk: KCN1, a Novel HIF Inhibitor Blocks Tumor Growth Through Binding of Plectin-1 and Inhibition of the HSP90 Pathway
Short Talk: KCN1, a Novel HIF Inhibitor Blocks Tumor Growth Through Binding of Plectin-1 and Inhibition of the HSP90 Pathway
*
Mark W. Dewhirst,
Duke University Medical Center, USA
Exploring Oxidative Stress and HIF-1 in Early Angiogenesis and Response to Radiotherapy and Chemotherapy
Exploring Oxidative Stress and HIF-1 in Early Angiogenesis and Response to Radiotherapy and Chemotherapy
Annamaria Rapisarda,
SAIC-Frederick, Inc., USA
Short Talk: Antitumor Activity of Antiangiogenic Agents Combined with HIF-1 Inhibitors: Blocking Hypoxic Dependent Survival Pathways Improves Therapeutic Efficacy
Short Talk: Antitumor Activity of Antiangiogenic Agents Combined with HIF-1 Inhibitors: Blocking Hypoxic Dependent Survival Pathways Improves Therapeutic Efficacy
08:00—11:00
Pathological Angiogenesis
Christiana DelloRusso,
Children's Hospital Boston, USA
Short Talk: Loss of p53 Tumor Suppressor Function may be Rescued by Re-Expression of the Endogenous Angiogenesis Inhibitors TSP-1 and Endostatin
Short Talk: Loss of p53 Tumor Suppressor Function may be Rescued by Re-Expression of the Endogenous Angiogenesis Inhibitors TSP-1 and Endostatin
Shira Landskroner,
Alexion Pharmaceuticals, USA
Short Talk: The Adipocyte-Derived Factor Adiponectin Contributes to Mammary Tumor Growth through Enhanced Angiogenesis
Short Talk: The Adipocyte-Derived Factor Adiponectin Contributes to Mammary Tumor Growth through Enhanced Angiogenesis
Gabriele A.I. Bergers,
University of Leuven, Belgium
Regulation and Function of Bone Marrow-Derived Cells in Tumors
Regulation and Function of Bone Marrow-Derived Cells in Tumors
Daniela C. Tirziu,
Yale University School of Medicine, USA
Short Talk: Angiogenesis-Driven Myocardial Hypertrophy
Short Talk: Angiogenesis-Driven Myocardial Hypertrophy
Yoshihide Asano,
Medical University of South Carolina, USA
Short Talk: Fli1 Impairs the Interaction of Endothelial Cells with Pericytes - a Possible Mechanism for Scleroderma Vasculopathy
Short Talk: Fli1 Impairs the Interaction of Endothelial Cells with Pericytes - a Possible Mechanism for Scleroderma Vasculopathy
Christopher G. Kevil,
Louisiana State University Health Sciences Center, USA
Short Talk: Endothelial Cav-1 Mediates Pathological Angiogenesis in the 3% DSS Model of Experimental Colitis
Short Talk: Endothelial Cav-1 Mediates Pathological Angiogenesis in the 3% DSS Model of Experimental Colitis
14:30—16:30
Workshop 3: Therapeutics
*
Amato J. Giaccia,
Stanford University, USA
Joseph R. Marszalek,
Merck Research Laboratories, USA
Using RNAi to Identify Modulators of the HIF Pathway/Hypoxia for Cancer
Using RNAi to Identify Modulators of the HIF Pathway/Hypoxia for Cancer
Navdeep S. Chandel,
Northwestern University, USA
A Chemical Genomics Screen Highlights the Essential Role of Mitochondria in HIF Regulation
A Chemical Genomics Screen Highlights the Essential Role of Mitochondria in HIF Regulation
Natalya A. Smirnova,
Burke Research Medical Institute, USA
High-throughput Screening for HIF Prolyl Hydroxylase Inhibitors
High-throughput Screening for HIF Prolyl Hydroxylase Inhibitors
Stephen John Klaus,
Fibrogen, USA
Induction of Erythropoiesis in Rodents by Novel and Distinct Families of Orally Active HIF Prolyl Hydroxylase Inhibitors
Induction of Erythropoiesis in Rodents by Novel and Distinct Families of Orally Active HIF Prolyl Hydroxylase Inhibitors
Sean P. Colgan,
University of Colorado Denver, USA
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
Shan Ping Yu,
Emory University School of Medicine, USA
In Vitro Hypoxic Preconditioning of Stem Cells as a Strategy of Promoting Cell Survival and Functional Benefits After Transplantation into the Ischemic Rat Brain
In Vitro Hypoxic Preconditioning of Stem Cells as a Strategy of Promoting Cell Survival and Functional Benefits After Transplantation into the Ischemic Rat Brain
Periannan Kuppusamy†,
Ohio State University, USA
Oxygen Sensing in Myocardial Stem Cell Therapy
Oxygen Sensing in Myocardial Stem Cell Therapy
14:30—16:30
Workshop 3: Vascular Cell Signaling
Suphansa Sawamiphak,
Max Planck Institute of Neurobiology, Germany
Eph/Ephrin-Mediated Endothelial Cell Interactions
Eph/Ephrin-Mediated Endothelial Cell Interactions
Masahiro Murakami,
Yale University School of Medicine, USA
Mechanism of FGF-Mediated Maintenance of Vascular Integrity
Mechanism of FGF-Mediated Maintenance of Vascular Integrity
Tetsuya Saito,
University of Tokyo, Japan
Molecular Mechanism of Alternative VEGFR-1 Gene Expression in Human Endothelial Cell
Molecular Mechanism of Alternative VEGFR-1 Gene Expression in Human Endothelial Cell
Robert C. Doebele,
University of Colorado, USA
Epac/Rap1 Inhibit Endothelial Cell Chemotaxis and Angiogenesis via Induction of Thrombospondin-1
Epac/Rap1 Inhibit Endothelial Cell Chemotaxis and Angiogenesis via Induction of Thrombospondin-1
17:00—19:00
Respiratory Disease
*
Peter A. Robbins,
University of Oxford, UK
Hypoxia and Mechanisms of Cardio-Respiratory Control in Humans
Hypoxia and Mechanisms of Cardio-Respiratory Control in Humans
Larrisa A. Shimoda,
Johns Hopkins School of Medicine, USA
Hypoxic Pulmonary Hypertension
Hypoxic Pulmonary Hypertension
Michael L. Maitland,
University of Chicago, USA
Short Talk: Developing the Anti-cancer VEGFR2/Multikinase Inhibitor Sorafenib for Treatment of Human Pulmonary Arterial Hypertension
Short Talk: Developing the Anti-cancer VEGFR2/Multikinase Inhibitor Sorafenib for Treatment of Human Pulmonary Arterial Hypertension
Agnes Görlach,
German Heart Center Munich, TU Munich, Germany
Short Talk: The Serum- and Glucocorticoid Regulated Kinase-1 is a Novel Regulator of Hypoxia-Inducible Factor 1
Short Talk: The Serum- and Glucocorticoid Regulated Kinase-1 is a Novel Regulator of Hypoxia-Inducible Factor 1
Michail Sitkovsky,
Northeastern University, USA
Iatrogenic Complication Due to Elimination of Hypoxia-driven, Immunosuppressive and Tissue Protecting Adenosinergic Pathway
Iatrogenic Complication Due to Elimination of Hypoxia-driven, Immunosuppressive and Tissue Protecting Adenosinergic Pathway
17:00—19:00
Novel Therapeutic Targets in Angiogenesis
*
Gabriele A.I. Bergers,
University of Leuven, Belgium
Zoltan P. Arany,
University of Pennsylvania, USA
Short Talk: HIF-Independent Regulation of VEGF and Angiogenesis by the Metabolic Sensor and Transcriptional Coactivator PGC-1á
Short Talk: HIF-Independent Regulation of VEGF and Angiogenesis by the Metabolic Sensor and Transcriptional Coactivator PGC-1á
Sara Weis,
University of California, San Diego, USA
Short Talk: Compensatory Role for Pyk2 during Angiogenesis in Adult Mice Lacking Endothelial Cell FAK
Short Talk: Compensatory Role for Pyk2 during Angiogenesis in Adult Mice Lacking Endothelial Cell FAK
Angela K. Nevins,
Indiana University School of Medicine, USA
Short Talk: The Role of VEGF-Induced Surface Expression of Nucleolin in Tumor Angiogenesis
Short Talk: The Role of VEGF-Induced Surface Expression of Nucleolin in Tumor Angiogenesis
Melanie A. Simpson,
University of Nebraska, USA
Short Talk: Prostate Tumor Growth, Vascularization, and Metastasis are Modulated by Differential Turnover of Hyaluronan
Short Talk: Prostate Tumor Growth, Vascularization, and Metastasis are Modulated by Differential Turnover of Hyaluronan
Kristin E. Hubert,
Oregon Health & Sciences University, USA
Short Talk: Trail Deficient Mice Exhibit Delayed Regression of Retinal Neovascularization
Short Talk: Trail Deficient Mice Exhibit Delayed Regression of Retinal Neovascularization
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge additional support for this conference from:
![]() |
![]() |
GeneBlue Corporation |
|
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka,
Director of Corporate Relations, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org, Phone:+1 970-262-1179 |