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This meeting took place in 2008
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Islet and Beta Cell Development and Transplantation (Z4)
Organizer(s) Chris Wright, Helena Edlund, David M. Harlan and Ray MacDonald
April 6—11, 2008
Snowbird Resort • Snowbird, UT USA
Abstract Deadline: Dec 6, 2007
Late Abstract Deadline: Jan 9, 2008
Scholarship Deadline: Dec 6, 2007
Early Registration Deadline: Feb 6, 2008
Supported by the Director's Fund
Joint Meeting:
Islet and Beta Cell Biology (Z3)
Summary of Meeting:
This meeting presents an integrated program on pancreatic islet developmental biology, islet transplantation, and immunity. It is designed to interdigitate with and to augment the companion parallel conference “Islet and Beta-Cell Biology”. The meeting will encompass pioneering science in several disciplines, including development, regeneration, stem cells, transcription factors, transplantation, cell biology, gene regulation, immunity, and diabetes. Islet transplantation as an emergent therapy for diabetes is severely hampered by an insufficient islet supply, gradually decreasing islet function post-transplantation, and by toxic immuno-suppression. Understanding the rules that guide pancreas development in vivo will promote methods to generate new islets from adult or embryonic stem cells, and yet our knowledge remains inadequate as it pertains to the mechanisms controlling normal islet development and function, or of the maintenance of the islet cell differentiated state, survival, and physiological function after transplantation. Similarly, the means elude us to safely, effectively, and reliably prevent recurrent immune attack on the transplanted islets. The meeting program focuses on these challenges by covering the most recent progress in these rapidly moving fields and discussing strategies to overcome major obstacles. The meeting builds upon the extremely strong foundation laid by the 2006 Keystone meeting on “Pancreatic Islets”, which very effectively brought together the fields of islet transplantation and basic pancreatic development. A most important aspect of the meeting will be the instructions given to the speakers to identify specific caveats and problems with the current state of research, to define short and long term goals for the field and, moreover, to orient their presentation in a manner that maximizes accessibility to attendees from the other research areas.
View Scholarships/Awards
This meeting presents an integrated program on pancreatic islet developmental biology, islet transplantation, and immunity. It is designed to interdigitate with and to augment the companion parallel conference “Islet and Beta-Cell Biology”. The meeting will encompass pioneering science in several disciplines, including development, regeneration, stem cells, transcription factors, transplantation, cell biology, gene regulation, immunity, and diabetes. Islet transplantation as an emergent therapy for diabetes is severely hampered by an insufficient islet supply, gradually decreasing islet function post-transplantation, and by toxic immuno-suppression. Understanding the rules that guide pancreas development in vivo will promote methods to generate new islets from adult or embryonic stem cells, and yet our knowledge remains inadequate as it pertains to the mechanisms controlling normal islet development and function, or of the maintenance of the islet cell differentiated state, survival, and physiological function after transplantation. Similarly, the means elude us to safely, effectively, and reliably prevent recurrent immune attack on the transplanted islets. The meeting program focuses on these challenges by covering the most recent progress in these rapidly moving fields and discussing strategies to overcome major obstacles. The meeting builds upon the extremely strong foundation laid by the 2006 Keystone meeting on “Pancreatic Islets”, which very effectively brought together the fields of islet transplantation and basic pancreatic development. A most important aspect of the meeting will be the instructions given to the speakers to identify specific caveats and problems with the current state of research, to define short and long term goals for the field and, moreover, to orient their presentation in a manner that maximizes accessibility to attendees from the other research areas.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 6
MONDAY, APRIL 7
TUESDAY, APRIL 8
WEDNESDAY, APRIL 9
THURSDAY, APRIL 10
FRIDAY, APRIL 11
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 6
19:30—21:30
Keynote Session (Joint)
*
Chris Wright,
Vanderbilt University Medical Center, USA
Mark A. Magnuson,
Vanderbilt School of Medicine, USA
Beta Cells, Technology Convergence and Team Science
Beta Cells, Technology Convergence and Team Science
Andrew Hattersley,
University of Exeter Medical School, UK
What can Genetics Teach us about the Beta-Cell?
What can Genetics Teach us about the Beta-Cell?
08:00—11:00
Stem Cells and Optimization of Beta Cell Function to Transplantation (Joint)
*
Chris Wright,
Vanderbilt University Medical Center, USA
Frances M. Ashcroft,
Henry Wellcome Centre for Gene Function, University of Oxford, UK
Ion Channels and Diabetes
Ion Channels and Diabetes
Claes B. Wollheim,
University of Geneva Medical Centre, Switzerland
Integration of Beta-Cell Transcription and Metabolic Regulation
Integration of Beta-Cell Transcription and Metabolic Regulation
Klaus H. Kaestner,
University of Pennsylvania School of Medicine, USA
Using Functional Genomics to Identify Targets for Beta-Cell Expansion
Using Functional Genomics to Identify Targets for Beta-Cell Expansion
Douglas A. Melton,
Harvard University, USA
Making Beta Cells
Making Beta Cells
17:00—19:00
Understanding and Controlling Autoimmunity
*
David M. Harlan,
National Institutes of Health, NIDDK, USA
E. William St. Clair,
Duke University Medical Center, USA
Targeting B Cells in Autoimmune Disease
Targeting B Cells in Autoimmune Disease
Arlene H. Sharpe,
Harvard Medical School, USA
PD-L1 for Maintenance of Self-Tolerance
PD-L1 for Maintenance of Self-Tolerance
Thomas Kay,
St. Vincent's Institute of Medical Research, Australia
Short Talk: Insulin-Specific T Cells and Islet Inflammation Promote Initiation of Diabetes in IGRP-Specific T Cell Receptor Transgenic Mice
Short Talk: Insulin-Specific T Cells and Islet Inflammation Promote Initiation of Diabetes in IGRP-Specific T Cell Receptor Transgenic Mice
Shira Y. Perl,
National Institutes of Health, USA
Short Talk: Novel Techniques Suggest Limited beta Cell Turnover in Adult Humans
Short Talk: Novel Techniques Suggest Limited beta Cell Turnover in Adult Humans
17:00—19:00
Transcriptional Networks that Regulate Islet Function
*
Doris A. Stoffers,
Perelman School of Medicine, University of Pennsylvania, USA
Pdx1 Partners and Targets in ß Cell Development
Pdx1 Partners and Targets in ß Cell Development
Roland W. Stein,
Vanderbilt University Medical Center, USA
Transcriptional Control of Beta-Cell Function
Transcriptional Control of Beta-Cell Function
Raghavendra G. Mirmira,
Indiana University School of Medicine, USA
Constructing a Functional Beta Cell, One Histone at a Time
Constructing a Functional Beta Cell, One Histone at a Time
Chutima Noi Talchai,
Columbia University, USA
Short Talk: Regulation of Pancreatic Endocrine Progenitors and beta Cell Function by Transcription Factor Foxo1
Short Talk: Regulation of Pancreatic Endocrine Progenitors and beta Cell Function by Transcription Factor Foxo1
08:00—11:00
Pancreas Development - Transcription / Factors
Ray MacDonald,
University of Texas Southwestern Medical Center, USA
Transcriptional Control of Early Pancreatic Development
Transcriptional Control of Early Pancreatic Development
Lori Sussel,
University of Colorado Anschutz Medical Campus, USA
Nkx2.2: Transcriptional regulation of pancreatic islet differentiation
Nkx2.2: Transcriptional regulation of pancreatic islet differentiation
Helena Edlund,
Umeå University, Sweden
Signaling and Transcription Factors in the Pancreas
Signaling and Transcription Factors in the Pancreas
Chris Wright,
Vanderbilt University Medical Center, USA
Genetic Studies of PTF1a and PDX1 Function in the Main “Secondary Transition” Phase of Pancreatic Endocrine Cell Derivation
Genetic Studies of PTF1a and PDX1 Function in the Main “Secondary Transition” Phase of Pancreatic Endocrine Cell Derivation
Victoria E. Prince,
University of Chicago, USA
Short Talk: Localization of the Pancreatic Progenitor Field is Controlled by Retinoic Acid and Cdx4
Short Talk: Localization of the Pancreatic Progenitor Field is Controlled by Retinoic Acid and Cdx4
08:00—11:15
Metabolic Control of Insulin Secretion
*
Marc Prentki,
Montreal Diabetes Research Center, Canada
Alan D. Attie,
University of Wisconsin-Madison, USA
Multi-Dimensional Approaches to Identification of Genes Involved in Diabetes and Insulin Resistance
Multi-Dimensional Approaches to Identification of Genes Involved in Diabetes and Insulin Resistance
Charles A. Stanley,
Children's Hospital of Philadelphia, USA
Human Genetic Syndromes of Hyperinsulinism: Insights into Relevant Metabolic Pathways
Human Genetic Syndromes of Hyperinsulinism: Insights into Relevant Metabolic Pathways
Guy A. Rutter,
Imperial College London, UK
Genetic Associations and the Regulation Late Events in Insulin Exocytosis
Genetic Associations and the Regulation Late Events in Insulin Exocytosis
Richard G. Kibbey,
Yale University, USA
Metabolic Coupling between Mitochondrial GTP Synthesis and Insulin Secretion
Metabolic Coupling between Mitochondrial GTP Synthesis and Insulin Secretion
Christopher B. Newgard,
Duke University Medical Center, USA
Integration of Metabolic and Transcriptional Profiling for Understanding Regulation of Insulin Secretion
Integration of Metabolic and Transcriptional Profiling for Understanding Regulation of Insulin Secretion
17:00—19:00
Stem Cells and Pancreatic Islets
*
Douglas A. Melton,
Harvard University, USA
Gordon M. Keller,
University Health Network, MaRS Centre, Canada
Induction and Specification of Endoderm from Embryonic Stem Cells
Induction and Specification of Endoderm from Embryonic Stem Cells
Markus Grompe,
Oregon Health & Science University, USA
Characterization and Behavior of Liver and Pancreas Stem Cells
Characterization and Behavior of Liver and Pancreas Stem Cells
Maike Sander,
University of California, San Diego, USA
Transcriptional Regulators of Stem-Cellness
Transcriptional Regulators of Stem-Cellness
Jackie E. Lee,
Living Cell Technologies Limited, New Zealand
Short Talk: Generation of Insulin-Producing Islet-like Clusters from Human Embryonic Stem Cells
Short Talk: Generation of Insulin-Producing Islet-like Clusters from Human Embryonic Stem Cells
17:00—19:00
Mediators of Beta Cell Stress
*
R. Paul Robertson,
Pacific Northwest Research Institute, USA
Sheila Collins,
Vanderbilt University Medical Center, USA
Oxidative Stress, UCP2 and beta-Cell Function
Oxidative Stress, UCP2 and beta-Cell Function
Feroz R. Papa,
University of California, San Francisco, USA
New Tools to Adjust a Life-Death Switch in Cells Under ER Stress
New Tools to Adjust a Life-Death Switch in Cells Under ER Stress
Roger D. Cox,
Medical Research Council Harwell Institute, UK
Mitochondrial Nicotinamide Nucleotide Transhydrogenase (NNT) Impairs Insulin Secretion through UCP2
Mitochondrial Nicotinamide Nucleotide Transhydrogenase (NNT) Impairs Insulin Secretion through UCP2
Andreas C. Wiederkehr,
University of Geneva, Switzerland
Short Talk: Nutrient-Induced Mitochondrial Matrix Alkalinization Contributes to Signal Generation in the Pancreatic Beta Cell
Short Talk: Nutrient-Induced Mitochondrial Matrix Alkalinization Contributes to Signal Generation in the Pancreatic Beta Cell
08:00—11:15
Model Systems for Assessing Beta Cell Replacements
*
Ray MacDonald,
University of Texas Southwestern Medical Center, USA
Klaus Ulrich Pechhold,
University of Massachusetts, USA
Targeted Immune Approaches to Destroy Endogenous Beta Cells: Origin, Regulation, and Detection of Regenerative beta Cell Responses during Autoimmune Diabetes
Targeted Immune Approaches to Destroy Endogenous Beta Cells: Origin, Regulation, and Detection of Regenerative beta Cell Responses during Autoimmune Diabetes
Alvin C. Powers,
Vanderbilt University School of Medicine, USA
Imaging Approaches to Follow Beta Cells in Vivo
Imaging Approaches to Follow Beta Cells in Vivo
Yuval Dor,
Hebrew University-Hadassah Medical School, Israel
Determinants of Pancreatic Beta Cell Regeneration
Determinants of Pancreatic Beta Cell Regeneration
Holger Andreas Russ,
University of California, San Francisco, USA
Short Talk: Proliferation of Dedifferentiated Adult Human Pancreatic Beta Cells in vitro Revealed by Cell-Lineage Tracing
Short Talk: Proliferation of Dedifferentiated Adult Human Pancreatic Beta Cells in vitro Revealed by Cell-Lineage Tracing
Jake A. Kushner,
Baylor College of Medicine, USA
Short Talk: Beta-Cell Regeneration is Severely Restricted with Advanced Age
Short Talk: Beta-Cell Regeneration is Severely Restricted with Advanced Age
Emmanuel E. Baetge,
Nestlé Institute of Health Sciences, Switzerland
In vivo Generation of Glucose-Responsive Insulin-Secreting Cells from Human Embryonic Stem Cell-Derived Pancreatic Endoderm
In vivo Generation of Glucose-Responsive Insulin-Secreting Cells from Human Embryonic Stem Cell-Derived Pancreatic Endoderm
08:00—11:15
The Molecular Machinery of Insulin Secretion
Sara C. Kozma,
University of Cincinnati, USA
The Role of S6K1 in Beta-cell Growth is Independent of its Effects on the Development of Extra Embryonic Tissue
The Role of S6K1 in Beta-cell Growth is Independent of its Effects on the Development of Extra Embryonic Tissue
Tadao Shibasaki,
Kobe University Graduate School of Medicine, Japan
Roles of Exocytosis-Associated Proteins in Pancreatic Beta-Cells
Roles of Exocytosis-Associated Proteins in Pancreatic Beta-Cells
Debbie C. Thurmond,
Indiana University School of Medicine, USA
Regulation of Second-Phase Insulin Secretion by Cdc42, Syntaxin 4 and Munc18c
Regulation of Second-Phase Insulin Secretion by Cdc42, Syntaxin 4 and Munc18c
Tye Deering,
University of Texas Southwestern Medical Center, USA
Short Talk: The Protein Methyltransferase Set7/9 is Required for the Maintenance of Transcription and Euchromatin Structure at Islet-Enriched Genes
Short Talk: The Protein Methyltransferase Set7/9 is Required for the Maintenance of Transcription and Euchromatin Structure at Islet-Enriched Genes
Hainan Chen,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: The Polycomb Group Protein Ezh2 Controls Pancreatic beta Cell Growth by Repressing Ink4a/Arf
Short Talk: The Polycomb Group Protein Ezh2 Controls Pancreatic beta Cell Growth by Repressing Ink4a/Arf
Leslie Ann Caromile,
University of Connecticut Health Center, USA
Short Talk: The Neurosecretory Vesicle Protein Phogrin is a Phosphatidylinositol Phosphatase Whose Activity Regulates Insulin Secretion
Short Talk: The Neurosecretory Vesicle Protein Phogrin is a Phosphatidylinositol Phosphatase Whose Activity Regulates Insulin Secretion
Samuel B. Stephens,
Duke University Medical Center, USA
Short Talk: Potentiation of Glucose-Stimulated Insulin Secretion by a VGF-Derived Peptide
Short Talk: Potentiation of Glucose-Stimulated Insulin Secretion by a VGF-Derived Peptide
17:00—19:00
Pancreatic Development - Intercellular Signaling
*
Maike Sander,
University of California, San Diego, USA
Matthias Hebrok,
University of California, San Francisco, USA
Wnt and Hedgehog Signaling
Wnt and Hedgehog Signaling
Steven D. Leach,
Memorial Sloan Kettering, USA
Tails from the Deep: Exocrine Pancreas Differentiation in Mouse and Zebrafish
Tails from the Deep: Exocrine Pancreas Differentiation in Mouse and Zebrafish
Palle Serup,
University of Copenhagen, Denmark
Dll1 and Hes1 Regulate Pancreatic Endocrine Differentiation at Distinct Steps
Dll1 and Hes1 Regulate Pancreatic Endocrine Differentiation at Distinct Steps
Ondine Cleaver,
University of Texas Southwestern Medical Center, USA
Short Talk: Ephrin/Eph Signaling Modulates Pancreatic Development
Short Talk: Ephrin/Eph Signaling Modulates Pancreatic Development
17:00—19:00
Emerging Technologies for Beta-Cell Research
*
Roland W. Stein,
Vanderbilt University Medical Center, USA
Ali Mortazavi,
California Institute of Technology, USA
Mapping Mammalian Gene Regulatory Networks with ChIP-seq and RNA-seq
Mapping Mammalian Gene Regulatory Networks with ChIP-seq and RNA-seq
Thomas Kodadek,
The Scripps Research Institute, USA
Synthetic Transactivator Mimics for Specific Activation of Beta-Cell Genes
Synthetic Transactivator Mimics for Specific Activation of Beta-Cell Genes
Per-Olof Berggren,
Karolinska Institutet, Sweden
Insight into Pancreatic Beta Cell Function and Survival
Insight into Pancreatic Beta Cell Function and Survival
Thue W. Schwartz,
University of Copenhagen, Denmark
Short Talk: GPR39 Deficiency is Associated with Pancreatic beta Cell Dysfunction in Mice and Man
Short Talk: GPR39 Deficiency is Associated with Pancreatic beta Cell Dysfunction in Mice and Man
08:00—11:15
Moving Towards Clinical Application
Kevan C. Herold,
Yale University, USA
Effects of Immune Modulation on Beta Cells
Effects of Immune Modulation on Beta Cells
David M. Harlan,
National Institutes of Health, NIDDK, USA
Status of Clinical Trials Testing Beta Cell Regeneration
Status of Clinical Trials Testing Beta Cell Regeneration
*
Christian P. Larsen,
Emory University School of Medicine, USA
Costimulatory Pathway Based Clinical Trials
Costimulatory Pathway Based Clinical Trials
Keren Francis,
Technion - Israel Institute of Technology, Israel
Short Talk: Engineering Vascularized Pancreatic Islets In Vitro
Short Talk: Engineering Vascularized Pancreatic Islets In Vitro
Masahito Matsumoto,
Saitama Medical University, Japan
Short Talk: Regulation of Pancreatic Endocrine Cell Development by Integration between a Growth Factor and Notch Signaling Cascades
Short Talk: Regulation of Pancreatic Endocrine Cell Development by Integration between a Growth Factor and Notch Signaling Cascades
08:00—11:15
Beta-Cell Mechanisms: Lessons from Other Systems
*
Frances M. Ashcroft,
Henry Wellcome Centre for Gene Function, University of Oxford, UK
Patrik Rorsman,
Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Fuel Sensing in Islet Non-Beta Cells
Fuel Sensing in Islet Non-Beta Cells
Randy J. Seeley,
University of Michigan, USA
Fuel Sensing Mechanisms in the Brain: mTOR and the Regulation of Energy Balance
Fuel Sensing Mechanisms in the Brain: mTOR and the Regulation of Energy Balance
Johan M. Thevelein,
KU Leuven and VIB, Belgium
Novel Mechanisms in Sensing of Glucose and Other Essential Nutrients in Yeast
Novel Mechanisms in Sensing of Glucose and Other Essential Nutrients in Yeast
Fiona M. Gribble,
University of Cambridge, UK
Fuel-Sensing in the L-Cell
Fuel-Sensing in the L-Cell
Nils Wierup,
Lund University, Sweden
Short Talk: Cart is a Regulator of Islet Function and a Possible Incretin Hormone
Short Talk: Cart is a Regulator of Islet Function and a Possible Incretin Hormone
Kathryn Claiborn,
, USA
Short Talk: PCIF1 Regulates PDX1 Protein Stability, Glucose Homeostasis, and the Development of Pancreatic Beta Cell Mass
Short Talk: PCIF1 Regulates PDX1 Protein Stability, Glucose Homeostasis, and the Development of Pancreatic Beta Cell Mass
17:00—19:00
Islet Proliferation and Survival
*
Helena Edlund,
Umeå University, Sweden
Marc Y. Donath,
University Hospital Basel, Switzerland
Islet Inflammation and Treatment of Type 2 Diabetes with the IL-1 Receptor Antagonist
Islet Inflammation and Treatment of Type 2 Diabetes with the IL-1 Receptor Antagonist
Seung K. Kim,
Stanford University, USA
Control of Pancreas Cell Proliferation
Control of Pancreas Cell Proliferation
Sonya G. Fonseca,
Novartis, USA
Short Talk: Novel Regulation of ER Stress Signaling in Pancreatic beta-Cells by WFS1
Short Talk: Novel Regulation of ER Stress Signaling in Pancreatic beta-Cells by WFS1
17:00—19:00
Mechanisms of Beta-Cell Failure In Disease and Possible Drug Targets
*
Paul K. Burn,
Sanford Research & Sanford School of Medicine, USA
Nancy A. Thornberry,
Kallyope, Inc., USA
GLP-1 and Next Generation Insulin Secretagogues
GLP-1 and Next Generation Insulin Secretagogues
Peter C. Butler,
University of California, Los Angeles, USA
Beta Cell Mass, a Therapeutic Target or the Cards you are Dealt?
Beta Cell Mass, a Therapeutic Target or the Cards you are Dealt?
Jens Zehetner,
ETH Zurich, Switzerland, Switzerland
Short Talk: Regulation of Insulin Secretion and Glucose Homeostasis by the pVHL-HIF1a Axis
Short Talk: Regulation of Insulin Secretion and Glucose Homeostasis by the pVHL-HIF1a Axis
*Session Chair †Invited, not yet responded.
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