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This meeting took place in 2009
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The Many Faces of Ubiquitin (A4)
Organizer(s) Simona Polo, Christopher D. Lima and Vishva M. Dixit
January 11—16, 2009
Copper Mountain Resort • Copper Mountain, CO USA
Abstract Deadline: Sep 17, 2008
Late Abstract Deadline: Oct 14, 2008
Scholarship Deadline: Sep 17, 2008
Early Registration Deadline: Nov 11, 2008
Supported by the Directors' Fund
Summary of Meeting:
The ubiquitin (Ub) pathway controls many biological processes and determines how cells respond to growth factors, stress and genetic damage, controlling nearly every facet of a cell’s life and death. The covalent attachment of Ub to proteins can alter their localization, activities, and ultimate fate. One of the most intriguing features of the ubiquitin pathway is its emerging involvement in functions not directly related to protein degradation. In addition, some half-dozen related ubiquitin-like (Ubl) proteins, such as SUMO, are also revealing themselves as regulators of numerous cellular pathways. The existence of this vast and dynamic array of Ub and Ubl signals raises the central question of how specificity is achieved during conjugation, recognition, and signal transduction. Indeed, the molecular requirements for generating and recognizing various Ub signals are poorly understood and form a central unresolved issue in the field. This meeting will focus attention on the biology associated with Ub/Ubl-mediated signal transduction, including its role in human disease and cancer. The goal of this meeting is to gather a diverse array of scientists, not just “ubiquitinologists”, but also biologists whose work has been touched in some way by ubiquitin or ubiquitin-like pathways. By bringing together scientists from different backgrounds who work on a wide range of systems that are regulated by Ub and Ubl conjugation, this meeting will create a fertile ground for exchange of ideas on non-conventional functions for Ub and Ubl proteins in signal transduction.
View Scholarships/Awards
The ubiquitin (Ub) pathway controls many biological processes and determines how cells respond to growth factors, stress and genetic damage, controlling nearly every facet of a cell’s life and death. The covalent attachment of Ub to proteins can alter their localization, activities, and ultimate fate. One of the most intriguing features of the ubiquitin pathway is its emerging involvement in functions not directly related to protein degradation. In addition, some half-dozen related ubiquitin-like (Ubl) proteins, such as SUMO, are also revealing themselves as regulators of numerous cellular pathways. The existence of this vast and dynamic array of Ub and Ubl signals raises the central question of how specificity is achieved during conjugation, recognition, and signal transduction. Indeed, the molecular requirements for generating and recognizing various Ub signals are poorly understood and form a central unresolved issue in the field. This meeting will focus attention on the biology associated with Ub/Ubl-mediated signal transduction, including its role in human disease and cancer. The goal of this meeting is to gather a diverse array of scientists, not just “ubiquitinologists”, but also biologists whose work has been touched in some way by ubiquitin or ubiquitin-like pathways. By bringing together scientists from different backgrounds who work on a wide range of systems that are regulated by Ub and Ubl conjugation, this meeting will create a fertile ground for exchange of ideas on non-conventional functions for Ub and Ubl proteins in signal transduction.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 11
MONDAY, JANUARY 12
TUESDAY, JANUARY 13
WEDNESDAY, JANUARY 14
THURSDAY, JANUARY 15
FRIDAY, JANUARY 16
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 11
19:45—20:45
The Cecile Pickart Memorial Lecture
Daniel J. Finley,
Harvard University, USA
Regulation of Substrate Processing by the Proteasome
Regulation of Substrate Processing by the Proteasome
08:00—11:15
Signal Transduction by Ub (I)
David O. Morgan,
University of California, San Francisco, USA
Substrate Recognition by the Anaphase-Promoting Complex
Substrate Recognition by the Anaphase-Promoting Complex
J. Wade Harper,
Harvard Medical School, USA
Genetic and Proteomic Analysis of the Ubiquitin System
Genetic and Proteomic Analysis of the Ubiquitin System
Sirio Dupont,
University of Padova, Italy
Short Talk: A Deubiquitinating Enzyme Essential for TGFbeta Signaling Controls Smad4 Monoubiquitination
Short Talk: A Deubiquitinating Enzyme Essential for TGFbeta Signaling Controls Smad4 Monoubiquitination
Peter Kaiser,
University of California, Irvine, USA
Short Talk: Inactivation of SCF by Signal-Induced Disassembly
Short Talk: Inactivation of SCF by Signal-Induced Disassembly
17:00—19:00
Signal Transduction by Ub (II)
Simona Polo,
FIRC Institute of Molecular Oncology, Italy
Ubiquitin in Endocytosis and Signaling of EGFR
Ubiquitin in Endocytosis and Signaling of EGFR
Morag Park,
McGill University, Canada
Met Receptor Tyrosine Kinase: Intracellular Trafficking, Signal Polarisation and Transformation
Met Receptor Tyrosine Kinase: Intracellular Trafficking, Signal Polarisation and Transformation
Ming Xu,
University of Texas Southwestern Medical Center, USA
Ubiquitin in the NF-kappaB Pathway
Ubiquitin in the NF-kappaB Pathway
Mads Gyrd-Hansen,
University of Oxford, UK
Short Talk: IAPs Contain an Evolutionarily Conserved Ubiquitin-Binding Domain that is Essential for NF-kappaB Regulation and Oncogenesis
Short Talk: IAPs Contain an Evolutionarily Conserved Ubiquitin-Binding Domain that is Essential for NF-kappaB Regulation and Oncogenesis
08:00—11:15
Enzymes Regulation
*
Morag Park,
McGill University, Canada
Raymond J. Deshaies,
Amgen, Inc., USA
Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation
Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation
Brenda A. Schulman,
Max Planck Institute of Biochemistry, Germany
Mechanisms and Specificity of NEDD8ylation
Mechanisms and Specificity of NEDD8ylation
Jonathon Pines,
University of Cambridge, UK
Short Talk: How is the APC/C-Cdc20 Complex Regulated in Mitosis?
Short Talk: How is the APC/C-Cdc20 Complex Regulated in Mitosis?
Yang Xie,
Yale University, USA
Short Talk: Proteolytic Regulation of the Yeast MATalpha2 Transcription Factor by a SUMO-Targeted Ubiquitin Ligase (STUbL)
Short Talk: Proteolytic Regulation of the Yeast MATalpha2 Transcription Factor by a SUMO-Targeted Ubiquitin Ligase (STUbL)
R. Andrew Byrd,
NCI, National Institutes of Health, USA
Short Talk: Allosteric Activation of Ubiquitin Ligase Activity by a Novel E2 Binding Region
Short Talk: Allosteric Activation of Ubiquitin Ligase Activity by a Novel E2 Binding Region
14:30—16:30
Workshop 1: Tools and Reagents Development
*
Paul W. Sheppard,
Vacye Associates Limited, UK
State of the Art
State of the Art
Christopher Tsu,
Takeda Pharmaceuticals International Co., USA
Development of a Novel Charcoal Paper ATP: Pyrophosphate Exchange Assay: Kinetic Characterization of NEDD8 Activating Enzyme
Development of a Novel Charcoal Paper ATP: Pyrophosphate Exchange Assay: Kinetic Characterization of NEDD8 Activating Enzyme
Karen M. Kleman-Leyer,
Bellbrook Labs, USA
Monitoring AMP Flux through the SUMOylation Cascade Using the Transcreener AMP/GMP Assay
Monitoring AMP Flux through the SUMOylation Cascade Using the Transcreener AMP/GMP Assay
Michael H. Tatham,
University of Dundee, UK
System-Wide Analysis of Changes to the SUMO Proteome in Response to External Stimuli
System-Wide Analysis of Changes to the SUMO Proteome in Response to External Stimuli
Paul S. Andrews,
Amgen Inc, USA
Identification of SMURF1 Substrates Utilizing Protein Microarrays
Identification of SMURF1 Substrates Utilizing Protein Microarrays
Birte Kalveram,
University of Constance, Germany
Generation and Characterization of Monoclonal Antibodies Against the Ubiquitin-Like Modifier FAT10
Generation and Characterization of Monoclonal Antibodies Against the Ubiquitin-Like Modifier FAT10
17:00—19:00
Various Chains, Various Signals
Kazuhiro Iwai,
Osaka University, Japan
Physiological Function of Linear Polyubiquitin Chains
Physiological Function of Linear Polyubiquitin Chains
Michael Rape,
University of California, Berkeley, USA
The Assembly of K11-linked Ubiquitin Chains during Mitosis
The Assembly of K11-linked Ubiquitin Chains during Mitosis
Junmin Peng,
Emory University, USA
Analysis of Ubiquitinated Proteins and PolyUb Linkages by Quantitative Mass Spectrometry
Analysis of Ubiquitinated Proteins and PolyUb Linkages by Quantitative Mass Spectrometry
08:00—11:15
UBDs and UBLs Function and Specificity
Heran Darwin,
New York University School of Medicine, USA
Discovery of a Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis
Discovery of a Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis
Frauke Melchior,
Universität Heidelberg, Germany
Characterisation of the RanBP2 / RanGAP1*SUMO1 E3 Ligase Complex
Characterisation of the RanBP2 / RanGAP1*SUMO1 E3 Ligase Complex
Christian D. Schlieker,
Whitehead Institute for Biomedical Research, USA
Short Talk: A Functional Proteomics Approach Links the Ubiquitin-Related Modifier Urm1 to a RNA Modification Pathway
Short Talk: A Functional Proteomics Approach Links the Ubiquitin-Related Modifier Urm1 to a RNA Modification Pathway
Kate E. Stoll,
University of Washington, USA
Short Talk: Interaction of the E2s yeast Ubc4 and Human UbcH5 with Ub: Functional Consequence.
Short Talk: Interaction of the E2s yeast Ubc4 and Human UbcH5 with Ub: Functional Consequence.
14:30—16:30
Workshop 2: Animal Models
*
Ron R. Kopito,
Stanford University, USA
Ubiquitin Homeostasis on the Edge: Lessons from Polyubiquitin Knockout Mice
Ubiquitin Homeostasis on the Edge: Lessons from Polyubiquitin Knockout Mice
Pengbo Zhou,
Weill Cornell Medical College, USA
CULLIN 4A Knockout Mice
CULLIN 4A Knockout Mice
Nicholas John van Buuren,
Stanford University, USA
A Novel Family Of Viral Ankyrin/F-Box Proteins Interact With The SCF Complex
A Novel Family Of Viral Ankyrin/F-Box Proteins Interact With The SCF Complex
Maud Demarque,
Pasteur Institute, France
A Mouse Model for the Study of Sumo E2 Function
A Mouse Model for the Study of Sumo E2 Function
Michael R. Kuehn,
National Cancer Institute, National Institutes of Health, USA
Loss of SUMO-1 in Mice is not Lethal Due to Compensation by SUMO-2/3
Loss of SUMO-1 in Mice is not Lethal Due to Compensation by SUMO-2/3
Jongdae Lee,
University of California, San Diego, USA
STAT3 Maintains Intestinal Epithelial Barrier by Induction of Ubiquitin-Mediated Degradation of SNAI
STAT3 Maintains Intestinal Epithelial Barrier by Induction of Ubiquitin-Mediated Degradation of SNAI
Birgit Aerne,
Cancer Research UK, UK
A Uiquitin-Related RNAi Screen in Drosophila
A Uiquitin-Related RNAi Screen in Drosophila
17:00—19:00
Signal Transduction by UbIs
Deborah J. Lenschow,
Washington University School of Medicine, USA
Regulation of the Host Antiviral Response by ISG15
Regulation of the Host Antiviral Response by ISG15
Edward T.H. Yeh,
University of Texas MD Anderson Cancer Center, USA
Role of Sentrin/SUMO-Specific Protease 1 (SENP1) in Angiogenesis
Role of Sentrin/SUMO-Specific Protease 1 (SENP1) in Angiogenesis
Michael N. Boddy,
The Scripps Research Institute, USA
Short Talk: New Interactions of SUMO Pathway Enzymes in Genome Stability
Short Talk: New Interactions of SUMO Pathway Enzymes in Genome Stability
08:00—11:15
Ubiquitin and UbIs in Cancer
Lawrence R. Dick,
, USA
Targeting the NEDD8 Conjugation Pathway for Cancer Chemotherapy
Targeting the NEDD8 Conjugation Pathway for Cancer Chemotherapy
Roger Greenberg,
University of Pennsylvania, USA
Ubiquitin Recognition and Turnover in BRCA1-Dependent DNA Repair and Tumor Suppression
Ubiquitin Recognition and Turnover in BRCA1-Dependent DNA Repair and Tumor Suppression
Iannis Aifantis,
New York University School of Medicine, USA
Short Talk: The Fbw7 E3 Ubiquitin Ligase Controls Hematopoietic Stem Cell Self-Renewal and Transformation
Short Talk: The Fbw7 E3 Ubiquitin Ligase Controls Hematopoietic Stem Cell Self-Renewal and Transformation
Lian Li,
Emory University School of Medicine, USA
Short Talk: Parkin-Mediated Ubiquitin Signaling in Regulation of the Aggresome-Autophagy Pathway
Short Talk: Parkin-Mediated Ubiquitin Signaling in Regulation of the Aggresome-Autophagy Pathway
17:00—18:25
Regulation by Ub and UbIs in the Nucleus
Valentina Perissi,
Boston University School of Medicine, USA
Short Talk: Dismissal of Distinct Corepressor Complexes from Regulated Gene Promoters is Regulated by Specific Phosphorylation of the TBL1 and TBLR1 Exchange Factors
Short Talk: Dismissal of Distinct Corepressor Complexes from Regulated Gene Promoters is Regulated by Specific Phosphorylation of the TBL1 and TBLR1 Exchange Factors
18:25—19:15
Translational Research Lecture
Giulio F. Draetta,
University of Texas MD Anderson Cancer Center, USA
Druggable Targets in the Ubiquitin Field
Druggable Targets in the Ubiquitin Field
*Session Chair †Invited, not yet responded.
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