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This meeting took place in 2009
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Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6)
Organizer(s) R. Balfour Sartor, Lloyd F. Mayer, Charles O. Elson and Scott Plevy
January 13—18, 2009
Sagebrush Inn & Suites • Taos, NM USA
Abstract Deadline: Sep 18, 2008
Late Abstract Deadline: Oct 15, 2008
Scholarship Deadline: Sep 18, 2008
Early Registration Deadline: Nov 13, 2008
Supported by the Directors' Fund
Summary of Meeting:
Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the pathophysiology of chronic intestinal inflammation such as Crohn’s disease, ulcerative colitis and pouchitis and emphasize innate and adaptive immunoregulatory mechanisms that mediate mucosal homeostasis in a hostile environment. Major unresolved issues in mucosal immunology are as follows: (1) understanding how epithelial cells coexist with commensal intestinal bacteria, yet recognize the pathogenic organisms; (2) understanding how effector mechanisms in innate immune cells and T cells are appropriately downregulated; and (3) how understanding of basic immune regulation and inflammation can lead to the development of novel therapeutic agents for chronic inflammatory bowel diseases. This meeting presents state of the art lectures on the most recent research on innate, adaptive and regulatory immune responses to commensal bacteria, promotes interdisciplinary research interactions and explores several novel therapeutic approaches derived from recent pathogenic insights.
View Scholarships/Awards
Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the pathophysiology of chronic intestinal inflammation such as Crohn’s disease, ulcerative colitis and pouchitis and emphasize innate and adaptive immunoregulatory mechanisms that mediate mucosal homeostasis in a hostile environment. Major unresolved issues in mucosal immunology are as follows: (1) understanding how epithelial cells coexist with commensal intestinal bacteria, yet recognize the pathogenic organisms; (2) understanding how effector mechanisms in innate immune cells and T cells are appropriately downregulated; and (3) how understanding of basic immune regulation and inflammation can lead to the development of novel therapeutic agents for chronic inflammatory bowel diseases. This meeting presents state of the art lectures on the most recent research on innate, adaptive and regulatory immune responses to commensal bacteria, promotes interdisciplinary research interactions and explores several novel therapeutic approaches derived from recent pathogenic insights.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, JANUARY 13
WEDNESDAY, JANUARY 14
THURSDAY, JANUARY 15
FRIDAY, JANUARY 16
SATURDAY, JANUARY 17
SUNDAY, JANUARY 18
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, JANUARY 13
19:30—20:00
Welcoming Remarks
R. Balfour Sartor,
University of North Carolina at Chapel Hill, USA
Welcoming Remarks: An Overview of the Intestinal Microbiota and Mechanisms of Host/ Microbial Interactions
Welcoming Remarks: An Overview of the Intestinal Microbiota and Mechanisms of Host/ Microbial Interactions
08:00—11:15
Protective Role of Innate Mucosal Immune Responses to Commensal Microbiota
*
Lloyd F. Mayer,
Mount Sinai Medical Center, USA
Scott Plevy,
Janssen, USA
Protective Role of Heme Oxygenase and PI3 Kinase Isoforms
Protective Role of Heme Oxygenase and PI3 Kinase Isoforms
Maria T. Abreu,
University of Miami, Miller School of Medicine, USA
Mucosal TLR Regulation of Epithelial Integrity and Malignancy
Mucosal TLR Regulation of Epithelial Integrity and Malignancy
Eyal Raz,
University of California, San Diego, USA
Gut, Germs and Genes: The Tumorigenic Triad
Gut, Germs and Genes: The Tumorigenic Triad
Andrea Cerutti,
Mount Sinai School of Medicine, USA
Regulation of IgA Switching by Epithelial Cells in Response to Bacterial Stimuli
Regulation of IgA Switching by Epithelial Cells in Response to Bacterial Stimuli
Sergio A. Lira,
Mount Sinai School of Medicine, USA
Short Talk: TLRs, Chemokines and Intestinal Homeostasis
Short Talk: TLRs, Chemokines and Intestinal Homeostasis
Nouara Lhocine,
Institut Pasteur, France
Short Talk: PIMS Modulates Immune Tolerance to Commensal Bacteria by Regulating Drosophila Imd Pathway
Short Talk: PIMS Modulates Immune Tolerance to Commensal Bacteria by Regulating Drosophila Imd Pathway
17:00—19:00
Activation and Regulation of Mucosal NF-kappaB
*
Maria T. Abreu,
University of Miami, Miller School of Medicine, USA
Christian Jobin,
University of Florida, USA
Host/Microbes Interaction: Lessons from Gnotobiotic Murine and Zebrafish NF-kB Reporter Gene System
Host/Microbes Interaction: Lessons from Gnotobiotic Murine and Zebrafish NF-kB Reporter Gene System
Averil I. Ma,
University of California, San Francisco, USA
Ubiquitin and Innate Immunity: ABIN-1 and TNF Responses
Ubiquitin and Innate Immunity: ABIN-1 and TNF Responses
Maria del Carmen Alonso Cotoner,
Massachusetts General Hospital and Harvard Medical School, USA
Short Talk: GEF-H1 Mediates NOD1 Dependent NF-kB Activation Initiated by Shigella Flexneri Effectors
Short Talk: GEF-H1 Mediates NOD1 Dependent NF-kB Activation Initiated by Shigella Flexneri Effectors
Wen Zhou,
University of Texas Southwestern Medical Center, USA
Short Talk: Deletion of FoxO4 Elevates Susceptibility of Mice to Trinitrobenzene Sulfonic Acid-Induced Colitis
Short Talk: Deletion of FoxO4 Elevates Susceptibility of Mice to Trinitrobenzene Sulfonic Acid-Induced Colitis
Jun Sun,
University of Rochester, USA
Short Talk: Vitamin D Receptor Negatively Regulates in vivo NF-kappaB Activity in the Normal Colon and during Bacterial-Induced Intestinal Inflammation
Short Talk: Vitamin D Receptor Negatively Regulates in vivo NF-kappaB Activity in the Normal Colon and during Bacterial-Induced Intestinal Inflammation
08:00—11:15
Mechanisms of Bacterial Killing by Epithelial and Phagocytic Cells
*
R. Balfour Sartor,
University of North Carolina at Chapel Hill, USA
Jan Wehkamp,
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Germany
Antimicrobial Host Defense: from Epithelial Stem Cells to Chronic Inflammation
Antimicrobial Host Defense: from Epithelial Stem Cells to Chronic Inflammation
Lora V. Hooper,
University of Texas Southwestern Medical Center, USA
Innate Defense of Gut Epithelial Surfaces
Innate Defense of Gut Epithelial Surfaces
Arlette Darfeuille-Michaud,
Université d'Auvergne, France
Crohn’s Disease-Associated Adherent-Invasive E. coli: Mechanisms of Intestinal Colonization, Evasion of Intracellular Killing and Development of Gut Inflammation
Crohn’s Disease-Associated Adherent-Invasive E. coli: Mechanisms of Intestinal Colonization, Evasion of Intracellular Killing and Development of Gut Inflammation
Ye Yang,
University of Oregon, USA
Short Talk: IAP (Intestinal Alkaline Phosphatase) Up-Regulated by LPS Detoxifies LPS to Prevent Inflammation in Response to the Gut Microbiota
Short Talk: IAP (Intestinal Alkaline Phosphatase) Up-Regulated by LPS Detoxifies LPS to Prevent Inflammation in Response to the Gut Microbiota
Ajay S. Gulati,
University of North Carolina, Chapel Hill, USA
Short Talk: Effects of Murine Strain Variation on Intestinal Antimicrobial Peptide Expression
Short Talk: Effects of Murine Strain Variation on Intestinal Antimicrobial Peptide Expression
17:00—19:00
Dendritic Cell Function at Mucosal Surfaces
*
Scott Plevy,
Janssen, USA
Hans-Christian Reinecker,
Massachusetts General Hospital, USA
Dendritic Cell Function at the Mucosal Surfaces
Dendritic Cell Function at the Mucosal Surfaces
Peter Velázquez,
Indiana University School of Medicine - South Bend, USA
Short Talk: Delineating Mucosal Dendritic Cell Networks via Intravital Microscopy
Short Talk: Delineating Mucosal Dendritic Cell Networks via Intravital Microscopy
Jacqueline Perrigoue,
University of Pennsylvania, USA
Short Talk: Delineating Requirements for Antigen Presentation in the Intestine: Dendritic Cells and Beyond
Short Talk: Delineating Requirements for Antigen Presentation in the Intestine: Dendritic Cells and Beyond
Ting Feng,
Harvard Medical School, USA
Short Talk: Regulation of Toll-like Receptor 5 Gene Expression in Mucosal Dendritic Cells
Short Talk: Regulation of Toll-like Receptor 5 Gene Expression in Mucosal Dendritic Cells
R. William DePaolo,
University of Washington, USA
Short Talk: Regulation of Intestinal Immunity to Yersinia Enterocolitica by TLR1&TLR6
Short Talk: Regulation of Intestinal Immunity to Yersinia Enterocolitica by TLR1&TLR6
InYoung Kim,
University of Chicago, USA
Short Talk: The Role of Hsp70 in Intestinal Immune Homeostasis
Short Talk: The Role of Hsp70 in Intestinal Immune Homeostasis
08:00—11:15
Effector T Cell Responses in Intestinal Inflammation
*
Charles O. Elson,
University of Alabama, USA
Casey T. Weaver,
University of Alabama at Birmingham, USA
Late Plasticity in Th17 Development: a Basis for Revised Models of Intestinal Inflammtion
Late Plasticity in Th17 Development: a Basis for Revised Models of Intestinal Inflammtion
Bana Jabri,
University of Chicago, USA
Innate-Mediated Tolerance by TLR6: a Journey from Yersinia Pestis in the Gut
Innate-Mediated Tolerance by TLR6: a Journey from Yersinia Pestis in the Gut
Jesús Rivera-Nieves,
Inflammatory Bowel Disease Center, USA
Recruitment of T Cells to Chronically Inflamed Small Intestine
Recruitment of T Cells to Chronically Inflamed Small Intestine
Anisa S. Ismail,
Princeton University, USA
Short Talk: Reciprocal Interactions between Commensal Bacteria and gamma delta Intraepithelial Lymphocytes during Mucosal Injury
Short Talk: Reciprocal Interactions between Commensal Bacteria and gamma delta Intraepithelial Lymphocytes during Mucosal Injury
Kim Phung Le Nguyen,
University of California, San Diego, USA
Short Talk: Induction of Th17: Is It too Early for a Paradigm?
Short Talk: Induction of Th17: Is It too Early for a Paradigm?
17:00—19:00
Microbial Activation of Immune-Mediated Intestinal Inflammation
*
Casey T. Weaver,
University of Alabama at Birmingham, USA
Charles O. Elson,
University of Alabama, USA
Flagellin-Specific T Cell Responses in Experimental Colitis
Flagellin-Specific T Cell Responses in Experimental Colitis
Sandra Kim,
University of North Carolina, Chapel Hill, USA
Functional Characteristics of Escherichia Coli in Immune-Mediated Experimental Colitis
Functional Characteristics of Escherichia Coli in Immune-Mediated Experimental Colitis
Jochen Mattner,
Cincinnati Children's Hospital Medical Center, USA
The Role of Alphaproteobacteria in the Induction of Autoimmunity
The Role of Alphaproteobacteria in the Induction of Autoimmunity
Wendy S. Garrett,
Harvard School of Public Health, USA
Short Talk: Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
Short Talk: Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
08:00—11:15
Regulation of Mucosal Immune Response to Microbial Components
Craig L. Maynard,
University of Alabama at Birmingham, USA
Development of Gut-Protective Regulatory T Cells
Development of Gut-Protective Regulatory T Cells
Vijay K. Kuchroo,
Brigham and Women's Hospital, Harvard Medical School, USA
Tregs and Th17 Cells: Role of Induction and Regulation of Tissue Inflammation
Tregs and Th17 Cells: Role of Induction and Regulation of Tissue Inflammation
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Modulation of Foxp3+ Regulatory T Cells by Microbes
Modulation of Foxp3+ Regulatory T Cells by Microbes
William A. Faubion,
Mayo Clinic, USA
PRR Inhibition of Treg Apoptosis and the Pathigenesis of Crohn’s Disease
PRR Inhibition of Treg Apoptosis and the Pathigenesis of Crohn’s Disease
Betsy C. Taylor,
University of Pennsylvania, USA
Short Talk: TSLP Regulates Intestinal Immunity and Inflammation
Short Talk: TSLP Regulates Intestinal Immunity and Inflammation
17:00—19:00
Translation of Basic Research to Biomedical Applications
*
Scott Plevy,
Janssen, USA
Rene de Waal Malefyt,
Merck Research Labs, USA
The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases
The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases
Kevan C. Herold,
Yale University, USA
Induction of CD8+ Regulatory T Cells with Anti-CD3 Monoclonal Antibody
Induction of CD8+ Regulatory T Cells with Anti-CD3 Monoclonal Antibody
Huabao Xiong,
Mount Sinai School of Medicine, USA
Blocking the TLR Signaling Pathway using TLR Peptides in the Treatment of Colitis
Blocking the TLR Signaling Pathway using TLR Peptides in the Treatment of Colitis
Edwin F. de Zoeten,
Children's Hospital of Philadelphia, USA
Short Talk: Regulation of Foxp3+ Regulatory T Cells (Treg) by Small Molecule Targeting of HDAC6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models
Short Talk: Regulation of Foxp3+ Regulatory T Cells (Treg) by Small Molecule Targeting of HDAC6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models
*Session Chair †Invited, not yet responded.
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