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This meeting took place in 2010
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Molecular Targets for Control of Vector-Borne Diseases: Bridging Lab and Field Research (F2)
Organizer(s) Kenneth D. Vernick, Elena A. Levashina, Gerry Killeen and Anthony A. James
April 11—16, 2010
Copper Mountain Resort • Copper Mountain, Colorado USA
Abstract Deadline: Dec 11, 2009
Late Abstract Deadline: Jan 6, 2010
Scholarship Deadline: Dec 11, 2009
Early Registration Deadline: Feb 11, 2010
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Vigorous research since the completion of the Anopheles gambiae genome sequence has established the malaria mosquito as a model organism for host-pathogen biology. However, the translation of this growing post-genomic knowledge base into new vector-targeted malaria control strategies is a distinct challenge that now leads laboratory-based molecular researchers to confront the complexity and heterogeneity of the natural malaria transmission system. Simultaneously, a body of field-based vector researchers has been developing new ways to utilize existing vector control tools such as bednets and insecticides that, if consistently implemented, can yield impressive outcomes. Lab and field based practitioners attend different meetings and rarely engage in direct dialog. This conference will examine the tension between the development of new practical malaria control tools, including genomic ones, and the advantages of more fully exploiting existing tools. It is hoped that the scientific discussion will help influence individual and programmatic research priorities.
View Scholarships/Awards
Vigorous research since the completion of the Anopheles gambiae genome sequence has established the malaria mosquito as a model organism for host-pathogen biology. However, the translation of this growing post-genomic knowledge base into new vector-targeted malaria control strategies is a distinct challenge that now leads laboratory-based molecular researchers to confront the complexity and heterogeneity of the natural malaria transmission system. Simultaneously, a body of field-based vector researchers has been developing new ways to utilize existing vector control tools such as bednets and insecticides that, if consistently implemented, can yield impressive outcomes. Lab and field based practitioners attend different meetings and rarely engage in direct dialog. This conference will examine the tension between the development of new practical malaria control tools, including genomic ones, and the advantages of more fully exploiting existing tools. It is hoped that the scientific discussion will help influence individual and programmatic research priorities.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 11
MONDAY, APRIL 12
TUESDAY, APRIL 13
WEDNESDAY, APRIL 14
THURSDAY, APRIL 15
FRIDAY, APRIL 16
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 11
19:30—21:30
Keynote Address (Joint)
Michael F. Good,
Griffith University, Australia
Malaria Vaccines: Lessons from Immune Escape Instruct New Strategies
Malaria Vaccines: Lessons from Immune Escape Instruct New Strategies
Anthony A. James,
University of California, Irvine, USA
Transgenic Strategies for Pathogen Transmission Control
Transgenic Strategies for Pathogen Transmission Control
08:00—11:00
Vector Populations
*
Gerry F. Killeen,
Liverpool School of Tropical Medicine, UK
Didier Fontenille,
Institut de Recherche pour le Developpement (IRD), France
Complexity of the Malaria Vectorial System in Africa
Complexity of the Malaria Vectorial System in Africa
Nora J. Besansky,
University of Notre Dame, USA
Chromosome Structural Polymorphism and the Malaria Transmission System
Chromosome Structural Polymorphism and the Malaria Transmission System
Gregory Lanzaro,
University of California, Davis, USA
The Genetic Structure of Anopheles Gambiae Populations
The Genetic Structure of Anopheles Gambiae Populations
William C. Black IV,
Colorado State University, USA
Population Genetics of Aedes aegypti and Dengue Transmission
Population Genetics of Aedes aegypti and Dengue Transmission
08:00—11:15
Parasite Interactions with the Immune System
Paolo Arese,
University of Torino Medical School, Italy
Effects of Hemozoin and Hemozoin-Generated Molecules on Immune and Non-Immune Host Cells
Effects of Hemozoin and Hemozoin-Generated Molecules on Immune and Non-Immune Host Cells
James Brewer,
University of Glasgow, UK
Imaging Infection and Immune Responses in vivo
Imaging Infection and Immune Responses in vivo
Jean Langhorne,
Francis Crick Institute, UK
Kinetics of the Immune Response in Mice: Relevance for Human Malaria?
Kinetics of the Immune Response in Mice: Relevance for Human Malaria?
Takafumi Tsuboi,
Ehime University, Japan
Sexual Stage Parasites and Transmission-Blocking Antibodies
Sexual Stage Parasites and Transmission-Blocking Antibodies
Renée M. Tsolis,
University of California, Davis, USA
Short Talk: Malaria Parasite Infection Suppresses Mucosal Responses to Salmonella in the Intestine
Short Talk: Malaria Parasite Infection Suppresses Mucosal Responses to Salmonella in the Intestine
14:30—15:30
Special Topics
Debaditya Bhattacharya,
Tufts Medical Center, USA
Development of a Reservoir-Targeted Vaccine against Yersinia pestis
Development of a Reservoir-Targeted Vaccine against Yersinia pestis
Ramavati Pal,
St. John's University, USA
Insect Glutathione S-transferase Proteome and Insecticide Resistance
Insect Glutathione S-transferase Proteome and Insecticide Resistance
Linda De Vooght,
Institute of Tropical Medicine, Antwerp, Belgium
Expression of Trypanosome-Development Inhibitory Proteins into the Periplasm of Sodalis glossinidius, a Bacterial Symbiont of the Tsetse Fly
Expression of Trypanosome-Development Inhibitory Proteins into the Periplasm of Sodalis glossinidius, a Bacterial Symbiont of the Tsetse Fly
15:30—16:30
Vector Biology Funding Priorities and Perspectives
*
Adriana Costero-Saint Denis,
NIAID, National Institutes of Health, USA
Vector Biology Funding Opportunities at the National Institute of Allergy and Infectious Diseases
Vector Biology Funding Opportunities at the National Institute of Allergy and Infectious Diseases
Inmaculada Peñas Jiménez,
European Commission, CORDIS, Belgium
European Union Funded Research on Vector Biology
European Union Funded Research on Vector Biology
17:00—19:00
Olfaction, Host Seeking and Behavior
*
Anthony A. James,
University of California, Irvine, USA
Laurence J. Zwiebel,
Vanderbilt University, USA
Olfactory and Thermosensory Genomics as a Basis for Disrupting Disease Transmission by Vector Mosquitoes
Olfactory and Thermosensory Genomics as a Basis for Disrupting Disease Transmission by Vector Mosquitoes
Flaminia Catteruccia,
Harvard T.H. Chan School of Public Health, USA
Molecular Bases of Anopheles gambiae Reproductive Biology: A Laboratory and Field Study
Molecular Bases of Anopheles gambiae Reproductive Biology: A Laboratory and Field Study
Willem Takken,
Wageningen University, Netherlands
Olfaction and Behavioral Ecology of Disease Vectors
Olfaction and Behavioral Ecology of Disease Vectors
17:00—19:00
Recognizing Protective Immunity
*
John T. Harty,
University of Iowa, USA
Robert Sauerwein,
Radboud University, Netherlands
Complete Immunity after Limited Exposure to P. falciparum in a Controlled Setting
Complete Immunity after Limited Exposure to P. falciparum in a Controlled Setting
Eleanor M. Riley,
Roslin Institute, UK
Cross-Talk between Innate and Adaptive Immune Cells: Relevance for Assessing Effector Cell Responses to Malaria Vaccines
Cross-Talk between Innate and Adaptive Immune Cells: Relevance for Assessing Effector Cell Responses to Malaria Vaccines
Laurent Rénia,
Singapore Immunology Network, (SIgN), A*STAR, Singapore
Mechanisms of Acquired Immunity against Malaria Liver Stage Immunity
Mechanisms of Acquired Immunity against Malaria Liver Stage Immunity
Nathan W. Schmidt,
University of Louisville, USA
Short Talk: Plasmodium Species and Host Background Genes Profoundly Influence the Threshold of Memory CD8 T Cells Required for Protective Immunity
Short Talk: Plasmodium Species and Host Background Genes Profoundly Influence the Threshold of Memory CD8 T Cells Required for Protective Immunity
08:00—11:00
Insecticides and Resistance
Hilary Ranson,
Liverpool School of Tropical Medicine, UK
The Molecular Genetics of Insecticide Resistance in Mosquitoes
The Molecular Genetics of Insecticide Resistance in Mosquitoes
Maureen Coetzee,
University of Witwatersrand, South Africa
Insecticides and Malaria Epidemiology
Insecticides and Malaria Epidemiology
Brian D. Foy,
Colorado State University, USA
The Effects of Anthelmintics on Anthropophilic Mosquitoes in the Lab and Field
The Effects of Anthelmintics on Anthropophilic Mosquitoes in the Lab and Field
08:00—11:15
Local Milieu for Host-Parasite Interactions
Ute Frevert,
New York University School of Medicine, USA
Imaging the Immunobiology of Plasmodium in the Liver
Imaging the Immunobiology of Plasmodium in the Liver
Fidel P. Zavala,
Johns Hopkins Bloomberg School of Public Health, USA
Development of Memory CD8+ T Cells Against Malaria Liver Stages
Development of Memory CD8+ T Cells Against Malaria Liver Stages
Nick Crispe,
University of Washington, USA
Immune Responses in the Liver
Immune Responses in the Liver
Pierre Buffet,
Pitie-Salpetriere Hospital, France
Erythrocytes Squeezing across Splenic Slits and the Pathogenesis of Plasmodium falciparum Infection
Erythrocytes Squeezing across Splenic Slits and the Pathogenesis of Plasmodium falciparum Infection
Sandra March,
Massachusetts Institute of Technology, USA
Short Talk: Establishment of the Liver Stages of Plasmodium falciparum in a Microscale Human Liver Platform
Short Talk: Establishment of the Liver Stages of Plasmodium falciparum in a Microscale Human Liver Platform
Anne-Marie Zeeman,
Biomedical Primate Research Centre, Netherlands
Short Talk: An Efficient in vitro Culture System to Study Malaria Dormant Liver Stages
Short Talk: An Efficient in vitro Culture System to Study Malaria Dormant Liver Stages
17:00—19:00
Pathogen Receptors and Cellular Interactions
*
Kenneth D. Vernick,
Institut Pasteur, France
Robert E. Sinden,
Imperial College London, UK
The Cell Biology of Plasmodium in the Mosquito
The Cell Biology of Plasmodium in the Mosquito
Kenneth E. Olson,
Colorado State University, USA
Interactions between Arboviruses and the Mosquito’s RNAi Pathway
Interactions between Arboviruses and the Mosquito’s RNAi Pathway
Serap Aksoy,
Yale University School of Public Health, USA
Microbiome Influences on Host Vector Competence
Microbiome Influences on Host Vector Competence
17:00—19:00
Parasite Invasion and Arrest
*
Robert Sauerwein,
Radboud University, Netherlands
Maria M. Mota,
Instituto de Medicina Molecular, Portugal
Blood Stage /Plasmodium/ Parasites Suppress Co-Infection in the Liver
Blood Stage /Plasmodium/ Parasites Suppress Co-Infection in the Liver
Urszula Krzych,
Walter Reed Army Institute of Research, USA
Memory CD8+ T Cells in Experimental Models of Protective Immunity Induced by Attenuated Plasmodia Sporozoites
Memory CD8+ T Cells in Experimental Models of Protective Immunity Induced by Attenuated Plasmodia Sporozoites
Audrey Gego,
INSERM UMR S 945, France
Short Talk: Identification of New Hepatocyte Factors Involved in Malaria Liver Stage Infection by Large Scale RNAi Screening
Short Talk: Identification of New Hepatocyte Factors Involved in Malaria Liver Stage Infection by Large Scale RNAi Screening
08:00—11:00
Host-Parasite Evolution
*
Gerry F. Killeen,
Liverpool School of Tropical Medicine, UK
Louis Lambrechts,
Institut Pasteur, France
Genetic Specificity of Interactions between Dengue Viruses and Mosquito Vectors
Genetic Specificity of Interactions between Dengue Viruses and Mosquito Vectors
Marc A.T. Muskavitch,
Biogen, USA
Short Talk: Implementation of a High-Density SNP Genotyping Array for the Vector Mosquito Anopheles gambiae for Analysis of Population Structure and Genetic Mapping
Short Talk: Implementation of a High-Density SNP Genotyping Array for the Vector Mosquito Anopheles gambiae for Analysis of Population Structure and Genetic Mapping
08:00—11:15
Malarial Disease: Contribution of Host Response
Kate A. Fitzgerald,
University of Massachusetts Medical School, USA
The Innate Immune Response to Malaria
The Innate Immune Response to Malaria
Patrick E. Duffy,
NIAID, National Institutes for Health, USA
Malarial Disease and the Placenta
Malarial Disease and the Placenta
Nick M. Anstey,
Menzies School of Health Research, Australia
Disease Caused by Plasmodium vivax
Disease Caused by Plasmodium vivax
Andrew E. Armitage,
Weatherall Institute of Molecular Medicine, UK
Short Talk: Plasmodium falciparum Infected Erythrocytes Induce Hepcidin (HAMP) mRNA Synthesis by Peripheral Blood Mononuclear Cells
Short Talk: Plasmodium falciparum Infected Erythrocytes Induce Hepcidin (HAMP) mRNA Synthesis by Peripheral Blood Mononuclear Cells
Ana Paula Freitas do Rosario,
National Institute for Medical Research, UK
Short Talk: TH1 CD4+ T Cells are the Main Source of Protective IL-10 Against Immune-Mediated Pathology during Plasmodium chabaudi AS Infection
Short Talk: TH1 CD4+ T Cells are the Main Source of Protective IL-10 Against Immune-Mediated Pathology during Plasmodium chabaudi AS Infection
14:30—16:30
Workshop 2: Special Topics
Luciano A. Moreira,
Instituto de Pesquisas René Rachou-Fiocruz, Brazil
A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya and Plasmodium
A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya and Plasmodium
Kostas Iatrou,
National Centre for Scientific Research, Greece
Volatile Constituents of Plant Origin Bind Selectively Various Odorant Binding Proteins of the Malaria Vector Anopheles gambiae and Act as Strong Repellents Capable of Interfering with the Vector’s Host Seeking and Blood Feeding Activities
Volatile Constituents of Plant Origin Bind Selectively Various Odorant Binding Proteins of the Malaria Vector Anopheles gambiae and Act as Strong Repellents Capable of Interfering with the Vector’s Host Seeking and Blood Feeding Activities
Igor V. Sharakhov,
Virginia Polytechnic Institute, USA
Genome Landscape and Evolutionary Plasticity of Chromosomes in Malaria Mosquitoes
Genome Landscape and Evolutionary Plasticity of Chromosomes in Malaria Mosquitoes
Judith Lum Ndamukong,
University of Buea, Cameroon
Biting Densities and Transmission Potential of Malaria Vectors in the Mount Cameroon Region at Contrasting Altitudinal Zones
Biting Densities and Transmission Potential of Malaria Vectors in the Mount Cameroon Region at Contrasting Altitudinal Zones
Hirotaka Kanuka,
Jikei University School of Medicine, Japan
Midgut Bacteria Regulates Plasmodium Development in Malaria Vector Anopheles Mosquitoes
Midgut Bacteria Regulates Plasmodium Development in Malaria Vector Anopheles Mosquitoes
14:30—16:30
Workshop
*
Patrick E. Duffy,
NIAID, National Institutes for Health, USA
Angela A. Aggrey,
University of Rochester Medical Center, USA
The Role of Platelets in Experimental Cerebral Malaria
The Role of Platelets in Experimental Cerebral Malaria
Noah S. Butler,
University of Oklahoma Health Sciences Center, USA
Key Immune-Effector Molecules Differentially Regulate Memory CD8 T Cell-Mediated Immunity Against Liver Stage P. berghei versus P. yoelii Infection
Key Immune-Effector Molecules Differentially Regulate Memory CD8 T Cell-Mediated Immunity Against Liver Stage P. berghei versus P. yoelii Infection
Aubrey Cunnington,
London School of Hygiene and Tropical Medicine, UK
Impairment of Host Defence during Malaria: A Possible Consequence of Heme Oxygenase-1 Induction
Impairment of Host Defence during Malaria: A Possible Consequence of Heme Oxygenase-1 Induction
Lei Shong Lau,
University of Melbourne, Australia
The Generation of a Blood-stage Plasmodium berghei-specific CD8+ T Cell Receptor Transgenic Mouse Model
The Generation of a Blood-stage Plasmodium berghei-specific CD8+ T Cell Receptor Transgenic Mouse Model
Jenni C. Lawton,
National Institute for Medical Research, UK
The cir Multi-Gene Family of Plasmodium chabaudi
The cir Multi-Gene Family of Plasmodium chabaudi
Demba Sarr,
University of Georgia, USA
Differential Pregnancy Outcomes of Plasmodium chabaudi AS-Infected A/J and C57BL/6 Mice
Differential Pregnancy Outcomes of Plasmodium chabaudi AS-Infected A/J and C57BL/6 Mice
17:00—19:00
Insect Immunity
*
Anthony A. James,
University of California, Irvine, USA
Elena A. Levashina,
Max Planck Institute for Infection Biology, Germany
Complement-Like System in Immune Responses of Anopheles gambiae
Complement-Like System in Immune Responses of Anopheles gambiae
Alexander S. Raikhel,
University of California Riverside, USA
Mosquito Immune Signaling Pathways
Mosquito Immune Signaling Pathways
Kenneth D. Vernick,
Institut Pasteur, France
Mapping and Functional Dissection of Mosquito Resistance to Plasmodium
Mapping and Functional Dissection of Mosquito Resistance to Plasmodium
17:00—19:00
Systems Biology of the Immune Response
Bali Pulendran,
Stanford University School of Medicine, USA
Predicting Protective Immune Responses to Vaccines
Predicting Protective Immune Responses to Vaccines
Peter D. Crompton,
National Institutes of Health, USA
Using Protein Microarrays to Probe the Human Antibody Response to Plasmodium falciparum
Using Protein Microarrays to Probe the Human Antibody Response to Plasmodium falciparum
Johanna Daily,
Albert Einstein College of Medicine, USA
Parasite Transcriptional Respones to Physiologic Conditions
Parasite Transcriptional Respones to Physiologic Conditions
Erica M. Pasini,
Biomedical Primate Research Centre, Netherlands
Short Talk: Identification of a Small Exported Protein Strongly Associated with Sequestration through Proteomics of the Membranes of P. berghei Infected Erythrocytes (iRBCs)
Short Talk: Identification of a Small Exported Protein Strongly Associated with Sequestration through Proteomics of the Membranes of P. berghei Infected Erythrocytes (iRBCs)
08:00—11:00
Control Strategies - Current and Future I
*
Kenneth D. Vernick,
Institut Pasteur, France
Andrea Crisanti,
Imperial College London, UK
Homing Endonuclease Transgenes in the Main Human Malaria Vector Anopheles Gambiae: From Dominant Sterility to Genetic Drive
Homing Endonuclease Transgenes in the Main Human Malaria Vector Anopheles Gambiae: From Dominant Sterility to Genetic Drive
Gerry F. Killeen,
Liverpool School of Tropical Medicine, UK
Ecology: A Prerequisite for Malaria Elimination and Eradication
Ecology: A Prerequisite for Malaria Elimination and Eradication
Catherine Bourgouin,
Institut Pasteur, France
Vector Targeted Immunological Control of Malaria Transmission
Vector Targeted Immunological Control of Malaria Transmission
Christian Lengeler,
Swiss Tropical and Public Health Institute, Switzerland
From Technology Development and Field Validation to Large-Scale Vector Control Interventions
From Technology Development and Field Validation to Large-Scale Vector Control Interventions
08:00—11:15
Multigene Families: Role in Immunity and Pathology
Joseph D. Smith,
Seattle Biomedical Research Institute, USA
Structure-Function of DBL Domains and Vaccine Design
Structure-Function of DBL Domains and Vaccine Design
Peter R. Preiser,
Nanyang Technological University, Singapore
Understanding the Biological Role of Small Variant Antigens in Plasmodium
Understanding the Biological Role of Small Variant Antigens in Plasmodium
Lars Hviid,
University of Copenhagen, Denmark
The Naturally Acquired Human Antibody Response to Plasmodium falciparum Variant Surface Antigens
The Naturally Acquired Human Antibody Response to Plasmodium falciparum Variant Surface Antigens
Benoit Gamain,
Pasteur Institute, France
Short Talk: Full-Length Extracellular Region of the var2CSA Variant of PfEMP1 is Required for Specific, High-Affinity Binding to CSA
Short Talk: Full-Length Extracellular Region of the var2CSA Variant of PfEMP1 is Required for Specific, High-Affinity Binding to CSA
Marissa G. Vignali,
Seattle Biomedical Research Institute, USA
Short Talk: Differential Gene Expression in P. falciparum Field Samples of Variable Disease Severity
Short Talk: Differential Gene Expression in P. falciparum Field Samples of Variable Disease Severity
17:00—19:00
Control Strategies - Current and Future II
*
Kenneth D. Vernick,
Institut Pasteur, France
Gregor J. Devine,
Ifakara Health Institute, Tanzania
Adult Mosquitoes as Insecticide Delivery Agents
Adult Mosquitoes as Insecticide Delivery Agents
17:00—19:00
Inducing Optimal Protective Responses with Vaccines
John T. Harty,
University of Iowa, USA
Quantifying CD8 T Cell Mediated Anti-Plasmodium Immunity and Protective Immunity after Attenuated Parasite Immunization
Quantifying CD8 T Cell Mediated Anti-Plasmodium Immunity and Protective Immunity after Attenuated Parasite Immunization
Joanna Kubler Kielb,
National Institutes of Health, USA
A Bicomponent Pre-Erythrocytic Investigational Malaria Vaccine
A Bicomponent Pre-Erythrocytic Investigational Malaria Vaccine
Philip Bejon,
University of Oxford, UK
Immunity Induced by a Partially Protective Vaccine
Immunity Induced by a Partially Protective Vaccine
Julie Healer,
Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Preclinical Development of a Combined Vaccine Against Bloodstage P. falciparum Malaria
Short Talk: Preclinical Development of a Combined Vaccine Against Bloodstage P. falciparum Malaria
*Session Chair †Invited, not yet responded.
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