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This meeting took place in 2012
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Th17 Cells in Health and Disease (Q2)
Organizer(s) Chen Dong, Vijay K. Kuchroo, Jay K. Kolls and Brigitta Stockinger
February 5—10, 2012
Keystone Resort • Keystone, CO USA
Abstract Deadline: Oct 5, 2011
Late Abstract Deadline: Nov 7, 2011
Scholarship Deadline: Oct 5, 2011
Early Registration Deadline: Dec 5, 2011
Supported by an educational grant from Lilly USA, LLC
Joint Meeting:
The Biology of Cytokines (Q1)
Summary of Meeting:
Nearly five years ago, a new type of T cell, called the Th17 cell, was discovered. Th17 cells have unique regulation and have been shown to be associated with many types of immune diseases and cancer. Since the first Keystone Symposia meeting on Th17 cells in 2009, there has been rapid progress in our understanding of the roles of IL-17-producing T cells in innate immunity to infection, the plasticity of Th17 cell, and genetic diseases associated with Th17 defects. The goal of this second Keystone Symposia meeting on Th17 cells is to gather experts in basic and clinical research areas and provide a productively interactive forum to further our understanding of Th17 regulation and function in immune responses and diseases. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on The Biology of Cytokines, which will share a keynote address and two plenary sessions with this meeting.
View Scholarships/Awards
Nearly five years ago, a new type of T cell, called the Th17 cell, was discovered. Th17 cells have unique regulation and have been shown to be associated with many types of immune diseases and cancer. Since the first Keystone Symposia meeting on Th17 cells in 2009, there has been rapid progress in our understanding of the roles of IL-17-producing T cells in innate immunity to infection, the plasticity of Th17 cell, and genetic diseases associated with Th17 defects. The goal of this second Keystone Symposia meeting on Th17 cells is to gather experts in basic and clinical research areas and provide a productively interactive forum to further our understanding of Th17 regulation and function in immune responses and diseases. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on The Biology of Cytokines, which will share a keynote address and two plenary sessions with this meeting.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 5
MONDAY, FEBRUARY 6
TUESDAY, FEBRUARY 7
WEDNESDAY, FEBRUARY 8
THURSDAY, FEBRUARY 9
FRIDAY, FEBRUARY 10
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 5
20:00—21:45
Welcome and Keynote Session (Joint)
Diane Mathis,
Harvard Medical School, USA
Regulation of Autoimmune Disease by Intestinal Microbes: Good Bugs/Bad Bugs
Regulation of Autoimmune Disease by Intestinal Microbes: Good Bugs/Bad Bugs
08:00—11:00
Molecular Regulation of Th17 Cells
Anjana Rao,
La Jolla Institute for Allergy and Immunology, USA
Small Molecule Inhibitors of T Cell Responses in vivo
Small Molecule Inhibitors of T Cell Responses in vivo
Kenneth M. Murphy,
HHMI/Washington University School of Medicine, USA
Role of BATF Family Transcription Factors in Immune Cell Type Specificity
Role of BATF Family Transcription Factors in Immune Cell Type Specificity
Alexander Y. Rudensky,
HHMI/Memorial Sloan Kettering Cancer Center, USA
Regulatory T Cells and Control of Th17 Cells
Regulatory T Cells and Control of Th17 Cells
Elke Glasmacher,
, Germany
Short Talk: Regulation of Th17 Cell Differentiation by IRF-4/BATF/JunB Complexes
Short Talk: Regulation of Th17 Cell Differentiation by IRF-4/BATF/JunB Complexes
08:00—11:15
Innate Immunity
Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
IL-1 and the Inflammasome
IL-1 and the Inflammasome
Brendan J. Jenkins,
Hudson Institute of Medical Research, Australia
Cross-Talk between IL-6 Family Cytokines and TLRs in Inflammation and Cancer
Cross-Talk between IL-6 Family Cytokines and TLRs in Inflammation and Cancer
Danielle N. Kroetz,
University of Michigan, USA
Short Talk: Novel Role for the Th2 Cytokine TSLP in Controlling Intracellular Growth of a Fungal Pathogen
Short Talk: Novel Role for the Th2 Cytokine TSLP in Controlling Intracellular Growth of a Fungal Pathogen
James Harris,
Monash University, Australia
Short Talk: Autophagy Regulates Inflammation through the Control of IL-1beta and IL-23
Short Talk: Autophagy Regulates Inflammation through the Control of IL-1beta and IL-23
17:00—19:15
Innate Source and Function of Th17-Related Cytokines
*
Daniel J. Cua,
Merck Research Laboratories, USA
Kingston H.G. Mills,
Trinity College Dublin, Ireland
Role of the IL-1 Cytokine Family in Activating Th17 and gammadelta T Cells in Infection and Autoimmunity
Role of the IL-1 Cytokine Family in Activating Th17 and gammadelta T Cells in Infection and Autoimmunity
Bruno Silva-Santos,
University of Lisbon, Portugal
EMBO Young Investigator Lecture: In vivo Differentiation and Expansion of gammadelta T Cells
EMBO Young Investigator Lecture: In vivo Differentiation and Expansion of gammadelta T Cells
Yueh-hsiu Chien,
Stanford School of Medicine, USA
gammadelta T Cell Activation: Antigen Recognition vs. Environmental Cues
gammadelta T Cell Activation: Antigen Recognition vs. Environmental Cues
Hergen Spits,
University of Amsterdam, Netherlands
Regulation of IL-22 Production by Th22 Cells and Innate Lymphoid Cells
Regulation of IL-22 Production by Th22 Cells and Innate Lymphoid Cells
17:00—19:00
Metabolic Disease and Cancer
*
Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
Ajay Chawla,
Merck and University of California, San Francisco, USA
Innate Regulation of Adipose Tissue Metabolism
Innate Regulation of Adipose Tissue Metabolism
Chia-Lin Hsu,
National Yang-Ming University, Taiwan
Short Talk: Antigen-Mediated Skin Inflammation is Dependent on an IL-33/ST2 Pathway
Short Talk: Antigen-Mediated Skin Inflammation is Dependent on an IL-33/ST2 Pathway
08:00—11:15
Th17 Cells and Inflammatory Diseases
*
Brigitta Stockinger,
Francis Crick Institute, UK
Vijay K. Kuchroo,
Brigham and Women's Hospital, Harvard Medical School, USA
Th17 Cells in Autoimmunity and Tissue Inflammation
Th17 Cells in Autoimmunity and Tissue Inflammation
Alison L. Budelsky,
Janssen Pharmaceutical Companies of Johnson & Johnson, USA
IL-17RA as a Novel Therapeutic Target for the Treatment of Multiple Autoimmune Diseases
IL-17RA as a Novel Therapeutic Target for the Treatment of Multiple Autoimmune Diseases
Clare M. Lloyd,
Imperial College London, UK
IL-17 in Asthma
IL-17 in Asthma
Jingwu Zhang Zang,
GlaxoSmithKline, China
Role of Neurotrophin Leukemia Inhibitory Factor (LIF) in Th17 Cell Differentiation and Its Association with Neural Progenitor Cell Therapy in Autoimmune Disease
Role of Neurotrophin Leukemia Inhibitory Factor (LIF) in Th17 Cell Differentiation and Its Association with Neural Progenitor Cell Therapy in Autoimmune Disease
Simona Rolla,
University of Turin, Italy
Short Talk: Phenotypical and Functional Characterization of T Helper 22 Cells in Multiple Sclerosis Patients
Short Talk: Phenotypical and Functional Characterization of T Helper 22 Cells in Multiple Sclerosis Patients
Akihiko Yoshimura,
Keio University, Japan
Short Talk: Effect of Biological and Chemical JAK Inhibitors on Th17 and Inflammatory Disease Models
Short Talk: Effect of Biological and Chemical JAK Inhibitors on Th17 and Inflammatory Disease Models
08:00—11:15
Cytokines and Adaptive Processes
Thomas F. Tedder,
Duke University Medical Center, USA
Regulatory B Cell Production of IL-10 Directs Innate and Adaptive Immunity
Regulatory B Cell Production of IL-10 Directs Innate and Adaptive Immunity
Cecile King,
Garvan Institute of Medical Research, Australia
IL-21 and Mucosal Autoimmunity
IL-21 and Mucosal Autoimmunity
Richard M. Locksley,
HHMI/University of California, San Francisco, USA
Th2-Mediated Immunity: Who Does What?
Th2-Mediated Immunity: Who Does What?
K. Christopher Garcia,
Stanford University School of Medicine, USA
Molecular Insight into Signal Initiation by Interleukin-2 and Interleukin-15
Molecular Insight into Signal Initiation by Interleukin-2 and Interleukin-15
Hidehiro Yamane,
NIAID, National Institutes of Health, USA
Short Talk: Strong TCR Signal-Mediated Suppression of Th2 Differentiation Requires Presenilin Function Independent of Notch Pathway
Short Talk: Strong TCR Signal-Mediated Suppression of Th2 Differentiation Requires Presenilin Function Independent of Notch Pathway
Reiko Horai,
NEI, National Institutes of Health, USA
Short Talk: IFN-gamma is Critical for Pathogenesis of Autoimmune Uveitis in a Spontaneous Mouse Model
Short Talk: IFN-gamma is Critical for Pathogenesis of Autoimmune Uveitis in a Spontaneous Mouse Model
17:00—19:00
Th17 Cells and Cancer
*
Wenjun Ouyang,
Amgen, Inc., USA
Weiping Zou,
University of Michigan, USA
Human Th17 Cells have Stem Cell-Like Features
Human Th17 Cells have Stem Cell-Like Features
Nicholas P. Restifo,
NCI, National Institutes of Health, USA
Self-Renewal and Persistence of T Cell Subsets
Self-Renewal and Persistence of T Cell Subsets
Sergei B. Koralov,
New York University, USA
STAT3 in T Cells: At the Crossroads of Inflammation and Cancer
STAT3 in T Cells: At the Crossroads of Inflammation and Cancer
Xue-Zhong Yu,
Moffitt Cancer Center & Research Institute, USA
Short Talk: Reciprocal Regulation and Distinct Contribution of Th1 and Th17 Cells in Acute Graft-versus-Host Disease
Short Talk: Reciprocal Regulation and Distinct Contribution of Th1 and Th17 Cells in Acute Graft-versus-Host Disease
17:00—19:00
The Interferons
*
John J. O'Shea,
NIAMS, National Institutes of Health, USA
Carolina B. López,
University of Pennsylvania, USA
Type I IFN Induction: Antagonism vs. Viral Recognition, and the Role of Defective Genomes
Type I IFN Induction: Antagonism vs. Viral Recognition, and the Role of Defective Genomes
Virginia Pascual,
Cornell University, USA
Type I IFNs and Autoimmunity
Type I IFNs and Autoimmunity
Anne O'Garra,
Francis Crick Institute, UK
Cytokines Involved in the Pathogenesis of Tuberculosis
Cytokines Involved in the Pathogenesis of Tuberculosis
Marco Prinz,
University of Freiburg, Germany
Short Talk: Cytosolic RIG-I-Like Helicases Limit TH1/TH17 Mediated Autoimmunity in the CNS
Short Talk: Cytosolic RIG-I-Like Helicases Limit TH1/TH17 Mediated Autoimmunity in the CNS
08:00—11:00
Th17 Cell Deficiencies
Jean-Laurent Casanova,
Rockefeller University, USA
Life-Threatening Infectious Diseases of Childhood: Single-Gene Inborn Errors of Immunity?
Life-Threatening Infectious Diseases of Childhood: Single-Gene Inborn Errors of Immunity?
Manuela Raffatellu,
University of California, San Diego, USA
The Role of IL-17 and IL-22 during the Early Phase of Salmonella colitis
The Role of IL-17 and IL-22 during the Early Phase of Salmonella colitis
Laurence Zitvogel,
Institut Gustave Roussy, France
TH17/gammadeltaT17 Differentiation during Immunogenic Cell Death in Cancer
TH17/gammadeltaT17 Differentiation during Immunogenic Cell Death in Cancer
Hongbo Chi,
St. Jude Children's Research Hospital, USA
Short Talk: Programming of TH17 Differentiation and Inflammation by Dendritic Cell-Derived Innate Immune Signals
Short Talk: Programming of TH17 Differentiation and Inflammation by Dendritic Cell-Derived Innate Immune Signals
Sophie Cypowyj,
Rockefeller University, USA
Short Talk: Gain-of-Function Human STAT1 Mutation Impair IL-17 Immunity and Underlie Chronic Mucocutaneous Candidiasis
Short Talk: Gain-of-Function Human STAT1 Mutation Impair IL-17 Immunity and Underlie Chronic Mucocutaneous Candidiasis
08:00—11:15
Cytokines and Environmental Interfaces
Steven F. Ziegler,
Benaroya Research Institute, USA
TSLP and Lung Inflammation
TSLP and Lung Inflammation
Fiona M. Powrie,
University of Oxford, UK
IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal Inflammation and Colon Cancer
IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal Inflammation and Colon Cancer
Michael Croft,
La Jolla Institute for Allergy and Immunology, USA
TNFR Family Molecules and Lung Inflammation
TNFR Family Molecules and Lung Inflammation
Paula M. Oliver,
University of Pennsylvania, USA
Short Talk: Preventing IL-4 Production is Required for Appropriate T Cell Differentiation
Short Talk: Preventing IL-4 Production is Required for Appropriate T Cell Differentiation
Mark A. Travis,
University of Manchester, UK
Short Talk: Expression of the TGF-beta Activating Integrin alphav beta8 on Dendritic Cells: A Crucial Pathway for the Induction of Oral Tolerance
Short Talk: Expression of the TGF-beta Activating Integrin alphav beta8 on Dendritic Cells: A Crucial Pathway for the Induction of Oral Tolerance
17:00—19:00
Th17 Cells and Mucosal Immunity
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Commensal Pathogen Cross Talk at Barrier Surfaces
Commensal Pathogen Cross Talk at Barrier Surfaces
Shabaana Khader,
Washington University School of Medicine, USA
T Helper Subsets in Immunity to Pulmonary Intracellular Pathogens
T Helper Subsets in Immunity to Pulmonary Intracellular Pathogens
Stephen Rubino,
Brigham and Women's Hospital, USA
Short Talk: Plasticity of IL-17 T-Cell Responses to Enteric Infection
Short Talk: Plasticity of IL-17 T-Cell Responses to Enteric Infection
17:00—19:00
The IL-6 Family
Elina I. Zuniga,
University of California, San Diego, USA
Gp130 Signaling Cytokines During Chronic Viral Infection
Gp130 Signaling Cytokines During Chronic Viral Infection
Christopher A. Hunter,
University of Pennsylvania, USA
IL-6 and IL-27: Opposing Roles in the Regulation of TFH and B Cell Responses
IL-6 and IL-27: Opposing Roles in the Regulation of TFH and B Cell Responses
Lindsay L. Jones,
St. Jude Children's Research Hospital, USA
Short Talk: Distinct Heterodimer Pairing Criteria and Subunit Competition within the IL-12 Cytokine Family
Short Talk: Distinct Heterodimer Pairing Criteria and Subunit Competition within the IL-12 Cytokine Family
Simon A. Jones,
Cardiff University School of Medicine, UK
IL-6 in Anti-Microbial Host Defense and associated Inflammation-Induced Tissue Damage
IL-6 in Anti-Microbial Host Defense and associated Inflammation-Induced Tissue Damage
08:00—11:00
Th17 Cytokines and Regulators (Joint)
Daniel J. Cua,
Merck Research Laboratories, USA
IL-23 Control of Th17 and Treg Cells
IL-23 Control of Th17 and Treg Cells
John J. O'Shea,
NIAMS, National Institutes of Health, USA
STATs and Helper Cell Plasticity
STATs and Helper Cell Plasticity
Jobert G. Barin,
Johns Hopkins University, USA
Short Talk: GM-CSF Control of Macrophage Differentiation is a Critical Effector of Th17 Responses in vivo
Short Talk: GM-CSF Control of Macrophage Differentiation is a Critical Effector of Th17 Responses in vivo
17:00—19:00
Regulation and Function of IL-22 (Joint)
*
Federica Sallusto,
Università della Svizzera Italiana & ETH Zurich, Switzerland
Human T Cell Subsets in Inflammation
Human T Cell Subsets in Inflammation
Wenjun Ouyang,
Amgen, Inc., USA
Regulation and Function of IL-22 in Mucosal Immunity
Regulation and Function of IL-22 in Mucosal Immunity
Brigitta Stockinger,
Francis Crick Institute, UK
Beyond Th17 Cells
Beyond Th17 Cells
Jacob S. Lee,
Merck, USA
Short Talk: AHR is Required for the Development of Small Intestine Lymphoid Tissues and their Associated IL-22-Producing Lymphoid Cells
Short Talk: AHR is Required for the Development of Small Intestine Lymphoid Tissues and their Associated IL-22-Producing Lymphoid Cells
*Session Chair †Invited, not yet responded.
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