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This meeting took place in 2014

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Biology of B Cell Responses (Q4)

Organizer(s) Hedda Wardemann, Michael G. McHeyzer-Williams and Michel C. Nussenzweig
February 9—14, 2014
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 16, 2013
Abstract Deadline: Nov 14, 2013
Scholarship Deadline: Oct 16, 2013
Discounted Registration Deadline: Dec 10, 2013

Sponsored by BioLegend, Inc. and Celgene Corporation.

Summary of Meeting:
The requirements and processes relevant for the induction of protective B cell responses remain largely unclear, and inefficient or deregulated B cell responses are frequently associated with the development of diseases. The goal of this meeting is to deepen our understanding of the factors and mechanisms controlling and regulating B cell development, differentiation and activation under steady-state conditions and in autoimmunity, infection and B cell tumors. The specific aims are to: 1) Identify factors involved in the developmental programming and function of B cells; 2) Elucidate the mechanisms relevant for the establishment and maintenance of B cell self-tolerance; 3) Define how B cell responses are initiated and regulated; 4) Provide insight into the mechanisms and dynamics underlying germinal center responses; and 5) Establish the link between immunoglobulin gene diversification and B cell tumor development. The meeting will provide a platform for early-stage and established researchers to engage in interactive discussions on all aspects of the biology of B cell responses from B cell evolution to basic principles of B cell biology and human B cell immunology. It will thereby facilitate and booster the exchange of ideas and the initiation of collaborative research on B cells at an international level. Interactions will be fostered across disciplines. Access to the parallel meeting on “Prophylactic and Therapeutic Antibodies” will provide all attendees with the unique opportunity to engage in expanded interdisciplinary interaction with translational scientists from academia and industry.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


Arrival and Registration

Longs Peak Foyer



Red Cloud/Shavano/Torreys
Welcome and Keynote Address

Longs/Grays Peaks
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Deciphering the Guidance Cue Code for B Cell Immunity

Welcome and Keynote Address

Quandary Peak
* Margaret Karow, Akrevia Therapeutics, USA
Introductory Remarks

Joseph Miletich, Merck, USA
Antibody Therapeutic Indications: Expanding Beyond Cancer and Inflammatory Diseases

Programming B Cell Physiology

Longs/Grays Peaks
Barry P. Sleckman, University of Alabama Birmingham School of Medicine, USA
Regulation of B Cell Development by Signals from RAG-Mediated DNA Double Strand Breaks

Cornelis Murre, University of California, San Diego, USA
Global Analysis of Long-Range Genomic Interactions that Orchestrate Lymphocyte Cell Fate

Hassan Jumaa, Institute for Immunology, Ulm University Hospital, Germany
Pre B Cell Development

* Stephen L. Nutt, Walter and Eliza Hall Institute, Australia
Short Talk: The Intrinsic and Extrinsic Controls of Late B Cell Differentiation

Amy L. Kenter, University of Illinois College of Medicine, USA
Short Talk: Class Switch Recombination can Precede V(D)J Joining during Early B Cell Development: Consequences and Implications in vivo

Novel Antibody Therapy for Pain

Quandary Peak
* Margaret Karow, Akrevia Therapeutics, USA

Mark T. Brown, Pfizer, USA
Overview of Analgesic Efficacy and Safety of Tanezumab, a Monoclonal Antibody Targeting Nerve Growth Factor for Treatment of Chronic Pain

John A. Latham, Alder BioPharmaceuticals, USA
The Discovery and Development of an Anti-CGRP Antibody ALD403 for the Treatment of Migraine

Stephen P. Squinto, OrbiMed Healthcare Fund Management, USA
Development of a Terminal Complement Inhibitor for the Treatment of Life-Threatening Ultra Rare Chronic Diseases

Coffee Break

Longs Peak Foyer
Poster Setup

Red Cloud/Shavano/Torreys
Poster Viewing

Red Cloud/Shavano/Torreys
On Own for Lunch and Recreation

Workshop 1: From B Cell Selection and Homeostasis to Programming and Functions

Longs Peak
* Michael P. Cancro, University of Pennsylvania, USA

* Frances E. Lund, University of Alabama at Birmingham, USA

Jeffrey J. Bednarski, Washington University School of Medicine, USA
Signals from RAG DNA Breaks Attenuate Pre-BCR Activity through Sequential Activation of NF-kappaB2 and SpiC

Hannes Bergmann, John Curtin School of Medical Research, Australian National University, Australia
Removal of p8-CD74 Peptides by Intramembrane Endopeptidase SPPL2A Is Crucial for B Cell Survival

Barbara Bertocci, INSERM 783, France
KLHL6 Is an Adaptor of the Cullin-Based-E3-Ubiquitin Ligase Complex Responsible for Transitional B Cell Survival and Differentiation

Keith M. Hamel, AbbVie, Inc., USA
The Epigenetic Reader Cecr2 in B-Lymphopoiesis

Yogesh S. Jeelall, John Curtin School of Medical Research, Australian National University, Australia
Human Lymphoma Mutations Reveal CARD11 as the Switch between Self-Antigen-Induced B Cell Death or Proliferation and Autoantibody Production

Beatriz León, University of Alabama at Birmingham, USA
Prolonged Antigen Presentation by Immune Complex-Binding Dendritic Cells Programs Memory CD8 T Cells

Matthew S. Macauley, The Scripps Research Institute, USA
Siglec-Mediated B Cell Tolerance to Membrane Autoantigens

Trang T.T. Nguyen, University of California, Davis, USA
Secreted IgM Enforces B Cell Central Tolerance Induction

Workshop 1: Crossing the Blood-Brain Barrier

Quandary Peak
Jean E. Lachowicz, Angiochem, Canada
Creation of a Brain-Penetrant Peptide-Antibody Conjugate that Targets Brain Tumors and Increases Survival in Mice with Intracranial HER2+ Tumors

* Robert G. Thorne, Denali Therapeutics, USA
Bypassing the Blood-Brain Barrier to Directly Deliver Antibodies and Antibody Fragments to Central Nervous System Target Sites

Denise D. Karaoglu, AbbVie Bioresearch Center, USA
Uptake and Retention of DVD-Ig™ in Mouse Brain by Intravenous or Intraperitoneal Injection

Morten Hanefeld Dziegiel, Copenhagen University Hospital, Denmark
Maternofetal Transplacental Transport of Novel Recombinant IgG Antibodies Lacking Effector Functions – Treatment of Maternal Pathogenic Antibodies

Graham K. Farrington, Biogen Idec, USA
Intravenous Biological Activity of FC5Fc in Transporting Biologically Active Peptides across the BBB in a Hargreaves Model Correlates with Plasma Half-Life and Apparent Binding Affinity

Coffee Available

Longs Peak Foyer
Self-Tolerance and Autoimmunity

Longs/Grays Peaks
* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Germinal Center Selection for Lower Autoantigen Affinity and for V-Regions Blocked by N-Glycans: Redemption of Autoantibodies Carried by Anergic B Cells in the Pre-Immune Repertoire

Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
(De-)Regulation of B Cell Activation

Roberta Pelanda, University of Colorado Denver, USA
Positive and Negative Selection of Primary B Cells

Robert C. Rickert, Pfizer Inc., USA
Short Talk: B Cell Tolerance to Gut-Associated Antigens

Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: A Splenic Marginal Zone B-Cell Precursor with NOTCH2-Dependent Differentiation Properties in Humans

Treating Chronic Diseases of Metabolism with Antibody-Based Therapeutics

Quandary Peak
* John A. Latham, Alder BioPharmaceuticals, USA

Neil Stahl, Regeneron Pharmaceuticals, USA
Alirocumab : Fully Human Antibody against PCSK9 Reduced LDL-C Both in Monotherapy and in Combination with Statins and Other Lipid Lowering Therapies in Preclinical and Early Clinical Studies

Peter Libby, Brigham and Women's Hospital, USA
Inflammation and Atherosclerosis: A Rationale for Antibody Treatment

Estelle Trifilieff, Novartis Institutes for Biomedical Research, Switzerland
Restore and Maintain Strong Body through Antibody Treatment in Skeletal Muscle Wasting Diseases

Social Hour with Lite Bites

Red Cloud/Shavano/Torreys
Poster Session 1

Red Cloud/Shavano/Torreys



Red Cloud/Shavano/Torreys
Initiating and Regulating B Cell Responses

Longs/Grays Peaks
* Hedda Wardemann, German Cancer Research Center, Germany

Susan K. Pierce, NIAID, National Institutes of Health, USA
How B Cells Remember

Tomohiro Kurosaki, Osaka University, Japan
Calcium Signaling in B Lymphocytes

Jeffrey V. Ravetch, Rockefeller University, USA
Regulating B Cell Activation

Jürgen Wienands, Georg August University of Goettingen, Germany
Short Talk: Signal Perception by SLP65 Requires its Macromolecular Assembly at Vesicular Signaling Scaffolds

Maria A. Curotto de Lafaille, New York University School of Medicine, USA
Short Talk: Regulation of IgE Cell Differentiation and Memory

Kai-Michael Toellner, University of Birmingham, UK
Short Talk: Regulation of B Cell Responses by Antibody

Tailoring Therapeutics to Meet the Demands of Prophylactic and Long-Term Therapy

Quandary Peak
* Marc Retter, Amgen Inc., USA

Herren Wu, MedImmune, USA
Engineering Biosuperiors

Javier Chaparro-Riggers, Rinat-Pfizer Inc., USA
Improving PK and Cholesterol Lowering by a pH-Sensitive Anti-PCSK9-Antibody

Tomoyuki Igawa, Chugai Pharmabody Research, Singapore
Bispecific IgG Antibody against FIXa and FX (ACE910) for the Treatment of Hemophilia A

C.M. Hsieh, Merck & Co., USA
Short Talk:Generation of ABT-122, an Anti-TNF/IL-17 DVD-Ig™ Molecule as a Potential Therapeutic Candidate for Rheumatoid Arthritis

Coffee Break

Longs Peak Foyer
Poster Setup

Red Cloud/Shavano/Torreys
Poster Viewing

Red Cloud/Shavano/Torreys
On Own for Lunch and Recreation

Workshop 2: B Cell Activation and Control of B Cell Responses

Longs/Grays Peak
* Anthony L. DeFranco, University of California, San Francisco, USA

* Jürgen Wienands, Georg August University of Goettingen, Germany

Wenxia Song, University of Maryland, USA
Actin-Mediated Attenuation of B-Cell Receptor Signaling Is Important for the Maintenance of B-Cell Tolerance

Alberto Martin, University of Toronto, Canada
Genome-Wide Screen Identifies kin17 as a Factor Required for Immunoglobulin Class Switch Recombination

Javier M. Di Noia, Institut de Recherches Cliniques de Montreal, Canada
An Atypical Dominant-Negative Effect of Truncated AID Variants on Isotype Switching Explains the Autosomal Dominant HIGM2 Syndrome

Carla R. Nowosad, Rockefeller University, USA
Determining the Architecture and Function of Immune Synapses within B Cell Populations

Mark R. Boothby, Vanderbilt University Medical Center, USA
Signaling Pathways in B Cell Survival and Humoral Memory

Isabelle Robert, Institute of Genetics and Molecular and Cellular Biology
Immunoglobulin Class Switch Recombination Is Negatively Regulated by Parp3

Pia Dosenovic, Karolinska Institutet, Sweden
Slc15a4 Function in Plasmacytoid Dendritic Cells Is Required for in vivo Class Switch Recombination to IgG2c in Response to CpGA

Workshop 3: B Cell Responses to Foreign Antigens

Quandary Peak
* Nicole Baumgarth, University of California, Davis, USA

Roberto DiNiro, University of Pittsburgh, USA
The B Cell Response to Salmonella typhimurium: Promiscuous B Cell Recruitment for Early Ab Followed by Extrafollicular Affinity Maturation

Rebecca A. Elsner, University of Pittsburgh, USA
The Lyme Disease Agent B. burgdorferi Inhibits Immunological Memory Formation by Suppressing Functional Germinal Center Responses

Eliver Eid Bou Ghosn, Emory University, USA
HSC-Independent Development of Antigen-Specific B-1a Memory

E. Ashley Moseman, NINDS, National Institutes of Health, USA
Adoptive B Cell Immunotherapy Accelerates Control of Chronic Viral Infection

Noel T. Pauli, Adimab LLC, USA
Staphylococcus aureus Infection Induces Affinity Maturation Derived Protein A-Mediated Immune Evasion in Humans

Kristin M.S. Schroeder, National Jewish Health, USA
Characterizing the HIV Envelope Antibody Response by Marginal Zone B Cells

Cristina Gil-Cruz, Kantonsspital St.Gallen, Switzerland
MyD88 Dependent Signals on FRC-Like Cells on Peyer's Patches Control Immune Responses against Pathogens

Adnan R. Khan, UCB Celltech, UK
"The Breg Gets the Worm:" How Helminths Can Shed a Light on Regulatory B Cells

Coffee Available

Longs Peak Foyer
B Cell Responses to Foreign Antigens

Longs/Grays Peaks
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
B Cell Memory to Infection

* Patrick C. Wilson, University of Chicago, USA
B Cell Immunity to Influenza in Humans

Hedda Wardemann, German Cancer Research Center, Germany
B Cell Clonal Selection

Scott D. Boyd, Stanford University, USA
Short Talk: Convergent Antibodies Are a Hallmark of Influenza Vaccine Seroconversion

Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Short Talk: The Multifaceted Role of Il-21r/Stat3 Signaling in Regulating Humoral Immunity and Memory in Humans

Overcoming Challenging Indications for Antibody Therapeutics

Quandary Peak
* Margaret Karow, Akrevia Therapeutics, USA

Bruce L. Roberts, Vedanta Biosciences, USA
New Insights into the Mechanism of Action of Alemtuzumab

Ronald A. Ignotz, University of Massachusetts Medical School, USA
Short Talk: Topical Anti-TNF-alpha Antibody Enhances Wound Healing in Diabetic Mice

Andreas Grauer, Amgen, USA
Targeting Osteoporosis: Increasing Bone Strength with Antibodies against RANK-L and Sclerostin

Ronald B. DeMattos, Lilly Research Laboratories, USA
Engaging the Enemy: Improving the Efficacy of Anti- beta-Amyloid Antibodies

Social Hour with Lite Bites

Red Cloud/Shavano/Torreys
Poster Session 2

Red Cloud/Shavano/Torreys



Red Cloud/Shavano/Torreys
Regulating B Cell Immunity

Longs/Grays Peaks
Marc K. Jenkins, University of Minnesota Medical School, USA
Origins of CD4+ Effector and Memory T Cells during Bacterial Infection

Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Intra-Clonal Analysis of B Cell Memory

Carola G. Vinuesa, Australian National University, Australia
Novel Mechanisms Controlling Mouse and Human Follicular T Cell Homeostasis

Shane Crotty, La Jolla Institute for Immunology, USA
T Cell Help to B Cells: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh)

* Hai Qi, Tsinghua University, China
Short Talk: Short-Lived T-B Entanglement in the Germinal Center and the Generation of High-Affinity BM Plasma Cells

Hui Hu, University of Alabama at Birmingham, USA
Short Talk: Foxp1 Is a Rate-Limiting and Essential Negative Regulator of TFH Cell Differentiation

Andre Ballesteros-Tato, University of Alabama at Birmingham, USA
Short Talk: FoxP3+ Regulatory T Cells Promote Influenza-Specific Tfh Cell Responses in vivo by Regulating IL-2

Prophylaxis versus Therapeutic Treatment of Infectious Disease

Quandary Peak
* Michael A. Barry, Mayo Clinic, USA

Arturo Casadevall, Albert Einstein College of Medicine, USA
A New Synthesis for Antibody-Mediated Immunity

Deborah C. Molrine, University of Massachusetts Medical School, USA
Antibody Mixtures: Treating Clostridium difficile with an Antibody Combination

Charles Ken Stover, MedImmune, LLC, USA
A Novel Multi-Mechanistic Monoclonal Antibody for Treating P. aeruginosa Infections

Gene Tan, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Characterization of a Broadly Neutralizing Monoclonal Antibody that Targets the Fusion Domain of the Group 2 Hemagglutinin of Influenza A Virus

Coffee Break

Longs Peak Foyer
Poster Setup

Red Cloud/Shavano/Torreys
Poster Viewing

Red Cloud/Shavano/Torreys
On Own for Lunch and Recreation

Workshop 4: Follicular Helpers and Germinal Center Biology

Castle Peaks
* Ann M. Haberman, Yale University School of Medicine, USA

* Takaharu Okada, RIKEN, Japan

Simon N. Willis, Walter and Eliza Hall Institute, Australia
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism

Peter Sage, Harvard Medical School, USA
Specialization of Memory-Like Circulating T Follicular Helper and T Follicular Regulatory Cells

Michela Locci, University of Pennsylvania, USA
Human Blood CXCR5+ PD-1+CXCR3- CD4 T Cells Are Highly Functional Circulating Memory Tfh Cells

Tharu M. Fernando, Genentech, Inc., USA
Heat Shock Factor 1 Induces BCL6 to Mediate Stress Tolerance

Seung Goo Kang, Kangwon National University, South Korea
Essential Roles of miR-17~92 Family miRNAs in Regulating Lymphoid Effector Programs

Florian Weisel, University of Pittsburgh, USA
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

Alexander D. Gitlin, Rockefeller University, USA
Cellular Dynamics Underlying Selection of B Cells in the Germinal Center

Roy Ramiscal, John Curtin School of Medical Research, Australian National University, Australia
Germinal Center T Follicular Helper Cells Are a Metabolically Distinct Subset of Effector T Cells

Ziv Shulman, Weizmann Institute, Israel
Prolonged T Follicular Helper Cell Calcium Mobilization during B Cell Selection in Germinal Centers

Workshop 2: When an Antibody Isn't Enough

Quandary Peak
* Hilde Revets, Ablynx, Belgium

Barbara S. Fox, Tilos Therapeutics, Inc., USA
AVX-470: A Novel Orally-Delivered Polyclonal Anti-TNF Antibody Designed to Work Locally in the GI Tract

Anthony B. Cooper, Adimab, LLC, USA
Non-Viral Adeno Associated Virus-Based Platform for Stable Expression of Antibody Combination Therapeutics

Rastislav Tamaskovic, University of Zürich, Switzerland
Intermolecular Trapping of ErbB2 Receptor Disables ErbB Signaling Network and Induces Apoptosis in ErbB2-Addicted Tumors

Kipp Weiskopf, Stanford University, USA
High-Affinity SIRPalpha Variants Enhance Macrophage Destruction of Small Cell Lung Cancer

Nicholas J. Veomett, Weill Cornell Medical College, USA
Targeting the Intracellular WT1 Oncoprotein with Multiple Therapeutic Antibody Modalities

Workshop 5: B Cell Memory

Longs/Grays Peaks
* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany

* Stuart G. Tangye, Garvan Institute of Medical Research, Australia

Jean-Nicolas Schickel, Adimab, LLC, USA
Expanded VH4-34+IgG+ Memory B Cells in IRAK-4 and MyD88-Deficient and SLE Patients Recognize Commensal Bacteria

Alexander Frühwirth, Institute for Research in Biomedicine, Switzerland
Identification of a Marker for Recently Activated Memory B Cells

Pierre J. Milpied, The Scripps Research Institute, USA
Intraclonal Analysis of Memory B Cell Functional Plasticity

Justin J. Taylor, Fred Hutchinson Cancer Research Center, USA
Analysis of the Differentiation of a Single Antigen-Specific Naïve B Cell Early in the Primary Response

Niklas Engels, Georg August University Goettingen, Germany
The Immunoglobulin Tail Tyrosine in Surface IgG Promotes T Cell Independent Reactivation of IgG-Switched Memory B Cells

Tyani D. Chan, Garvan Institute of Medical Research, Australia
Novel Regulatory Control of IgE Antibody Responses

Kathryn A. Pape, University of Minnesota, USA
Generation of IgA Plasma Cells during a Secondary Response in the Absence of IgA Memory B Cells

Kaval Kaur, Agency for Science, Technology and Research, Singapore
SLE Patients Make Higher Affinity Antibody Responses to Influenza Vaccination

Coffee Available

Longs Peak Foyer
Germinal Center Biology

Longs/Grays Peaks
David M. Tarlinton, Monash University, Australia
The Impact of Arginine Methylation on B-Cell Responsiveness

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
The Ins and Outs of Germinal Centers: Selection, Generation and Identity

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Germinal Center Biology

* Gabriel D. Victora, Rockefeller University, USA
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers

Roger Sciammas, University of California, Davis, USA
Short Talk: Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

In vivo Induction of Therapeutic Antibodies for Prophylactic Treatment of Disease

Quandary Peak
* Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Redirecting the Immune Response of the Influenza Virus Hemagglutinin to the Conserved Stalk of the Hemagglutinin and Neuraminidase

Ronald G. Crystal, Weill Medical College of Cornell University, USA
Viral Vectors as Platforms for Anti-Addiction Vaccines

Lélia Delamarre, Genentech, Inc., USA
Antibody-Mediated Antigen Delivery for Vaccine Antigens to Dendritic Cells

Seleeke F. Flingai, University of Pennsylvania, USA
Short Talk: Generation of DNA Plasmid-Encoded Broadly Neutralizing Antibodies in vivo

Erin Crossey, University of New Mexico, USA
Short Talk: Generation of a Cholesterol-Lowering Vaccine that Targets PCSK9

Social Hour with Lite Bites

Red Cloud/Shavano/Torreys
Poster Session 3

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Red Cloud/Shavano/Torreys
Generation of Diversity (Joint)

Longs/Grays Peaks
Max D. Cooper, Emory University, USA
Immune System Ontogeny and Phylogeny

David G. Schatz, Yale University School of Medicine, USA
Targeting of V(D)J Recombination and Somatic Hypermutation

Cristina Rada, MRC Laboratory of Molecular Biology, UK
Ig Gene Mutagenesis

Frederick W. Alt, Boston Children's Hospital, USA
Role of Target Sequences in Frequency and Outcome of AID-Initiated Mutational and Deletional Events

* F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, Germany
Short Talk: Generation of Diversity: Beyond Genomic Changes

Changchun Xiao, The Scripps Research Institute, USA
Short Talk: MicroRNA-17~92 Plays a Causative Role in Lymphomagenesis by Coordinating Multiple Oncogenic Pathways

Carol E. Schrader, University of Massachusetts, USA
Short Talk: The Effect of AP Endonuclease on Somatic Hypermutation of IgH Variable Region Genes

Coffee Break

Longs Peak Foyer
On Own for Lunch and Recreation

Workshop 6: Ig Diversity and Biology of B Cell Tumors

Longs/Grays Peaks
* Eric Meffre, Yale University School of Medicine, USA

Nobuo Sakaguchi, Kumamoto University, Japan
GANP Plays a Regulatory Role in the Choice of DNA Repair Pathway by Dissociating DNA-PKcs in AID-Induced Immunoglobulin V-Region Diversification

Wai Yen Alfred Lim, MRC Laboratory of Molecular Biology, UK
Directed Evolution of scFvs Using the Hypermutating DT40 B-Cell Line

Xiaohua Wang, Asclepius Therapy, USA
A Source of the Single-Stranded DNA Substrate for Activation-Induced Deaminase during Somatic Hypermutation

Amanda C. Drennan, University of Wisconsin, Madison, USA
Canonical and Non-Canonical JAK1 Signaling in Diffuse Large B-Cell Lymphoma

Virginia G. de Yébenes, Centro Nacional de Investigaciones Cardiovasculares, Spain
miR-217 Is an Oncogene that Enhances the Germinal Center Reaction

Daniel Gadala-Maria, Yale University, USA
Genotyping Methods for Improving Detection of Immunoglobulin Mutations

Adrienne Greenough, Duke University, USA
Identifying the Landscape of Genetic Alterations in the Lymphoma Transcriptome

Sébastien Storck, Institut Necker-Enfants Malades, France
AID Expression Restricted to the G1 Phase of the Cell Cycle Recapitulates the Mutation Spectrum of Immunoglobulin Genes

Workshop 3: What We Are Learning about Antibody Therapeutics

Quandary Peak
* Peter Brams, Zai Lab, USA

Fabricio Montalvao, Institut Pasteur, France
The Mechanism of Anti-CD20-Mediated B-Cell Depletion Revealed by Intravital Imaging

Karin A. van Schie, Sanquin Research, University of Amsterdam, Netherlands
Anti-Drug Antibodies to All Anti-TNFalpha Therapeutic Antibodies Are Largely Neutralizing

Nancy E. Everds, Amgen, Inc, USA
Off-Target Effects of Therapeutic mAbs on Peripheral Blood Cells

Stefan Barghorn, AbbVie, Inc., Germany
Off Target Toxicity of an Anti-Amyloid Beta Antibody for Alzheimer's Disease Immunotherapy

Mark J. Kwakkenbos, AIMM Therapeutics, Netherlands
In vitro B Cell Affinity Maturation Selects for Antibodies with Increased Neutralizing Activity and Stability

Nathan J. Alves, Indiana University, USA
Advancing Antibody Targeted Therapies through Site-Specific UV Conjugation of Functional Ligands to the Conserved Antibody Nucleotide Binding Site (NBS)

Coffee Available

Longs Peak Foyer
B Cell Cancer Biology

Longs/Grays Peaks
Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Modeling B Cell Lymphomagenesis in Mice

Louis M. Staudt, NCI, National Institutes of Health, USA
Therapies Targeting Pathological Signaling in B Cell Lymphomas

Riccardo Dalla-Favera, Columbia University, USA
Molecular Genetics of Diffuse Large B Cell Lymphoma

* Ralf Küppers, University of Duisburg-Essen, Medical School, Germany
Short Talk: Aspects of the Pathogenesis of Hodgkin Lymphoma

Uttiya Basu, , USA
Short Talk: Noncoding RNA Processing Promotes AID Targeting to the B Cell Genome

What We've Learned from Antibody Treatment of Inflammation

Quandary Peak
* Neil Graham, Regeneron Pharmaceuticals, USA

Meena Subramanyam, Biogen Idec, USA
Immunogenicity of Monoclonal Antibody Therapeutics: Experiences and Lessons Learned

Neil Graham, Regeneron Pharmaceuticals, USA
Lessons Learned in the Therapeutic Blockade of Th2 Inflammation in Asthma and Atopic Dermatitis Culminating in Dupilumab, a blocker of IL4 Receptor

Thomas A. Waldmann, National Institutes of Health, USA
What We Are Still Learning about Anti-CD25 Therapy after 25 Years with Daclizumab

Social Hour with Lite Bites

Red Cloud/Shavano/Torreys

Red Cloud/Shavano/Torreys



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

BioLegend, Inc. Celgene Corporation

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AI109612-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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