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This meeting took place in 2014
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Pathogenesis of Respiratory Viruses (J5)
Organizer(s) Adolfo García-Sastre and Peter J.M. Openshaw
January 19—24, 2014
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 9, 2013
Abstract Deadline: Oct 31, 2013
Scholarship Deadline: Oct 9, 2013
Discounted Registration Deadline: Nov 19, 2013
Sponsored by AstraZeneca
Joint Meeting:
Innate Immunity to Viral Infections (J6)
Summary of Meeting:
Respiratory viruses are a major cause of infectious disease and death in humans. The Keystone Symposia meeting on "Pathogenesis of Respiratory Viruses" will discuss some of the latest advances in our understanding of the biology and pathogenesis of this group of viruses, including major human pathogens such as influenza viruses, respiratory syncytial virus, parainfluenza virus, rhinoviruses, coronaviruses and adenoviruses. There will be a special emphasis on influenza and respiratory syncytial virus. This meeting will bring together experts in virology, viral pathogenesis and viral immunity to discuss factors contributing to viral replication, tropism, disease and immunity in the respiratory tract. Opportunities for synergistic interactions will be significantly enhanced by the concurrent meeting on "Innate Immunity to Viral Infections," resulting in a more integrated view of viral disease and immunity.
View Scholarships/Awards
Respiratory viruses are a major cause of infectious disease and death in humans. The Keystone Symposia meeting on "Pathogenesis of Respiratory Viruses" will discuss some of the latest advances in our understanding of the biology and pathogenesis of this group of viruses, including major human pathogens such as influenza viruses, respiratory syncytial virus, parainfluenza virus, rhinoviruses, coronaviruses and adenoviruses. There will be a special emphasis on influenza and respiratory syncytial virus. This meeting will bring together experts in virology, viral pathogenesis and viral immunity to discuss factors contributing to viral replication, tropism, disease and immunity in the respiratory tract. Opportunities for synergistic interactions will be significantly enhanced by the concurrent meeting on "Innate Immunity to Viral Infections," resulting in a more integrated view of viral disease and immunity.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 19
MONDAY, JANUARY 20
TUESDAY, JANUARY 21
WEDNESDAY, JANUARY 22
THURSDAY, JANUARY 23
FRIDAY, JANUARY 24
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 19
08:00—10:00
Keynote Session (Joint)
*
Adolfo García-Sastre,
Mount Sinai School of Medicine, USA
*
Caetano Reis e Sousa,
Francis Crick Institute, UK
RLRs in Immunity to Viruses
RLRs in Immunity to Viruses
Peter M. Palese,
Icahn School of Medicine at Mount Sinai, USA
Why Do Influenza Viruses Undergo Antigenic Drift and Shift and What Can We Do About It?
Why Do Influenza Viruses Undergo Antigenic Drift and Shift and What Can We Do About It?
10:20—12:00
Viral Entry and Replication
Glycoprotein structure, viral entry and genome replication.
*
Yoshihiro Kawaoka,
University of Wisconsin / University of Tokyo, USA
Ian A. Wilson,
The Scripps Research Institute, USA
Structural Basis of Influenza HA Function and Neutralization
Structural Basis of Influenza HA Function and Neutralization
James E. Crowe, Jr.,
Vanderbilt University Medical Center, USA
Host-Virus Interactions during RSV Infection
Host-Virus Interactions during RSV Infection
Robert A. Lamb,
Northwestern University, USA
The Mechanism of Entry into Cells by Membrane Fusion for Respiratory Negative Strand Viruses
The Mechanism of Entry into Cells by Membrane Fusion for Respiratory Negative Strand Viruses
10:20—12:00
Antiviral Strategies Across Taxa
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
*
Sara R. Cherry,
University of Pennsylvania, USA
Luciano A. Marraffini,
Rockefeller University, USA
Tolerance during CRISPR-Cas Immunity: Domesticating the Virus
Tolerance during CRISPR-Cas Immunity: Domesticating the Virus
Jean-Luc Imler,
Institut de Biologie Moléculaire et Cellulaire, France
Sensing and Signaling Viral Infection in Drosophila
Sensing and Signaling Viral Infection in Drosophila
Shou-Wei Ding,
University of California, Riverside, USA
RNAi as an Antiviral Strategy across Species, including Vertebrates
RNAi as an Antiviral Strategy across Species, including Vertebrates
14:30—16:30
Workshop 1: Virus-Host Interactions
*
James E. Crowe, Jr.,
Vanderbilt University Medical Center, USA
*
Cecilia Johansson,
Imperial College London, UK
Victor Stalinraj,
Erasmus Medical Center, Netherlands
Characterization of DPP4 as the Functional Receptor for Middle East Respiratory Syndrome Coronavirus
Characterization of DPP4 as the Functional Receptor for Middle East Respiratory Syndrome Coronavirus
Monika Bajorek,
Imperial College London, UK
Human RSV M Protein Interactions with Host Proteins Reveal New Cellular Ligands Involved in Viral Nuclear Localization and Innate Defense
Human RSV M Protein Interactions with Host Proteins Reveal New Cellular Ligands Involved in Viral Nuclear Localization and Innate Defense
Kavestri Yegambaram,
University of Auckland, New Zealand
Protein Interactions Underpinning Movement of the Viral Polymerase Diverge in the Paramyxovirinae
Protein Interactions Underpinning Movement of the Viral Polymerase Diverge in the Paramyxovirinae
Patricia S. Domingues,
University of Glasgow, UK
Non-Canonical Interplay between Influenza Virus and the Host SUMO System
Non-Canonical Interplay between Influenza Virus and the Host SUMO System
Raymond J. Pickles,
University of North Carolina, Chapel Hill, USA
Respiratory Syncytial Virus NS2 Protein Promotes Shedding of Virus-Infected Epithelial Cells Resulting in Acute Distal Airway Obstruction
Respiratory Syncytial Virus NS2 Protein Promotes Shedding of Virus-Infected Epithelial Cells Resulting in Acute Distal Airway Obstruction
Christopher Brooke,
NIAID, National Institutes of Health, USA
Illuminating the Dark Matter of Influenza A Virus Infection: Dynamic Viral Gene Expression Patterns within the “Non-Infectious” Virus Population
Illuminating the Dark Matter of Influenza A Virus Infection: Dynamic Viral Gene Expression Patterns within the “Non-Infectious” Virus Population
Nicholas S. Heaton,
Icahn School of Medicine at Mount Sinai, USA
Genome-Wide Mutagenesis of Influenza Virus: Unique Plasticity of the Hemagglutinin and NS1 Proteins
Genome-Wide Mutagenesis of Influenza Virus: Unique Plasticity of the Hemagglutinin and NS1 Proteins
Hugh D. Mitchell,
Pacific Northwest National Laboratory, USA
Integration of Proteomics Data Focuses Pathogenicity Pathways from Influenza Infection
Integration of Proteomics Data Focuses Pathogenicity Pathways from Influenza Infection
14:30—16:30
Workshop 1: Innate Virus Sensors
*
John Hiscott,
Vaccine & Gene Therapy Institute of Florida, USA
David E. Levy,
New York University School of Medicine, USA
Regulation of IFN Production and Response during Viral Infections
Regulation of IFN Production and Response during Viral Infections
Eva-Katharina Pauli,
Boston College, USA
USP15 Promotes RIG-I Antiviral Signaling by Stabilizing TRIM25
USP15 Promotes RIG-I Antiviral Signaling by Stabilizing TRIM25
Sun Hur,
Harvard Medical School, USA
RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent and Ubiquitin-Independent Manner
RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent and Ubiquitin-Independent Manner
Hao-Sen Chiang,
National Taiwan University, Taiwan
GEF-H1 Mediates Microtubule-Dependent Sensing of Nucleic Acids for Antiviral Host Defenses
GEF-H1 Mediates Microtubule-Dependent Sensing of Nucleic Acids for Antiviral Host Defenses
Chen Seng Ng,
Kyoto University, Japan
Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses
Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses
Søren Riis Paludan,
University of Aarhus, Denmark
Gammaherpesviruses Evade Innate Immune Activation via Cytosolic DNA Sensors to Allow Establishment of Chronic Infection
Gammaherpesviruses Evade Innate Immune Activation via Cytosolic DNA Sensors to Allow Establishment of Chronic Infection
Pingwei Li,
Texas A&M University, USA
Cyclic GMP-AMP Synthase is Activated by Double-Stranded DNA- Induced Oligomerization
Cyclic GMP-AMP Synthase is Activated by Double-Stranded DNA- Induced Oligomerization
17:00—19:00
Virus-Host Interactions
Host factors required for replication, impact of viral infection in cell functions.
*
Tracy Hussell,
University of Manchester, UK
Yoshihiro Kawaoka,
University of Wisconsin / University of Tokyo, USA
Influenza Virus Pathogenesis and Transmission
Influenza Virus Pathogenesis and Transmission
Ursula J. Buchholz,
NIAID, National Institutes of Health, USA
Evasion of the Adaptive Immune Response by HRSV and HMPV
Evasion of the Adaptive Immune Response by HRSV and HMPV
J. Kenneth Baillie,
University of Edinburgh, UK
Host Genetic Susceptibility and Viral Pathogenesis
Host Genetic Susceptibility and Viral Pathogenesis
Sharon K. Kuss,
University of Texas Southwestern Medical Center, USA
Short Talk: Influenza A Virus RNA Splicing is Regulated by Cellular Proteins NS1-BP and hnRNP K
Short Talk: Influenza A Virus RNA Splicing is Regulated by Cellular Proteins NS1-BP and hnRNP K
17:00—19:00
Effector Responses and Viral Evasion
*
Zhijian "James" Chen,
University of Texas Southwestern Medical Center, USA
Sara R. Cherry,
University of Pennsylvania, USA
Autophagy Nutrient Signaling and Antiviral Defenses
Autophagy Nutrient Signaling and Antiviral Defenses
Kanako Kuniyoshi,
iOsaka University, Japan
Short Talk: Pivotal Role of RNA-Binding E3 Ubiquitin Ligase Mex3c in RIG-I-Mediated Antiviral Innate Immunity
Short Talk: Pivotal Role of RNA-Binding E3 Ubiquitin Ligase Mex3c in RIG-I-Mediated Antiviral Innate Immunity
Michael Gale, Jr.,
University of Washington, USA
Differential Innate Antiviral Effector Responses Impart Outcome of Pathogenic and Nonpathogenic Flavivirus Infection
Differential Innate Antiviral Effector Responses Impart Outcome of Pathogenic and Nonpathogenic Flavivirus Infection
Andrew G. Bowie,
Trinity College Dublin, Ireland
Unexpected Roles for the TLR Adaptors TRAM and SARM in Anti-Viral Gene Induction
Unexpected Roles for the TLR Adaptors TRAM and SARM in Anti-Viral Gene Induction
08:00—11:15
Virus Detection by the Host (Joint)
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
*
Charles M. Rice,
Rockefeller University, USA
Teunis B.H. Geijtenbeek,
University of Amsterdam, Netherlands
C-Type Lectin Receptors as Virus Sensors or ‘Dupes’
C-Type Lectin Receptors as Virus Sensors or ‘Dupes’
Kate A. Fitzgerald,
University of Massachusetts Medical School, USA
Long Non-Coding RNA and Innate Immunity
Long Non-Coding RNA and Innate Immunity
Zhijian "James" Chen,
University of Texas Southwestern Medical Center, USA
Innate Immune Sensing of Cytosolic DNA
Innate Immune Sensing of Cytosolic DNA
Juris A. Grasis,
San Diego State University, USA
Short Talk: Viral Recognition in the Basal Metazoan Hydra
Short Talk: Viral Recognition in the Basal Metazoan Hydra
Akshay A. D'Cruz,
Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: A Two-Site Interaction Underpins TRIM25 Activation of the RIG-I Anti-Viral Response
Short Talk: A Two-Site Interaction Underpins TRIM25 Activation of the RIG-I Anti-Viral Response
Karl-Peter Hopfner,
Ludwig-Maximilians-University Munich, Germany
Talk Title to be Announced
Talk Title to be Announced
17:00—19:00
Innate Immunity in Pathogenesis
*
Adolfo García-Sastre,
Mount Sinai School of Medicine, USA
*
Ben Hale,
University of Glasgow, UK
Peter Staeheli,
University of Freiburg, Germany
Role of Interferon in Influenza Virus Defense
Role of Interferon in Influenza Virus Defense
Cecilia Johansson,
Imperial College London, UK
Interferon Responses to Respiratory Syncytial Virus (RSV) Infection
Interferon Responses to Respiratory Syncytial Virus (RSV) Infection
Deborah J. Lenschow,
Washington University School of Medicine, USA
Regulation of the Host Response to Viral Infection by ISG15
Regulation of the Host Response to Viral Infection by ISG15
Amy C. Graham,
Montana State University, USA
Short Talk: Influenza A Virus Activates Mast Cells to Enhance Viral-Induced Pathology
Short Talk: Influenza A Virus Activates Mast Cells to Enhance Viral-Induced Pathology
17:00—19:00
Signaling Responses to Virus Infection
MAVS, STING, inflammasome.
*
Andrew G. Bowie,
Trinity College Dublin, Ireland
Yong-Jun Liu,
Sanofi, USA
Biochemical Characterization of Nucleic Acid Sensors in Dendritic Cells
Biochemical Characterization of Nucleic Acid Sensors in Dendritic Cells
Kate L. Jeffrey,
Harvard Medical School, USA
Short Talk: Antiviral Defense in Mammals Mediated by Argonautes 2 and 4
Short Talk: Antiviral Defense in Mammals Mediated by Argonautes 2 and 4
Glen N. Barber,
University of Miami, USA
STING at the Crossroads of Cell-Intrinsic DNA Sensing
STING at the Crossroads of Cell-Intrinsic DNA Sensing
Veit Hornung,
Ludwig-Maximilians-University Munich, Germany
Spreading of Antiviral Immunity via Gap Junctions
Spreading of Antiviral Immunity via Gap Junctions
08:00—11:00
Induction of Immunity at Epithelial Surfaces (Joint)
Dendritic cells, innate responses in the lung, inflammation.
*
Peter J.M. Openshaw,
Imperial College London, UK
Andreas Wack,
Francis Crick Institute, UK
Short Talk: Interferon in Flu
Short Talk: Interferon in Flu
Ricardo Rajsbaum,
University of Texas Medical Branch, USA
Short Talk: Activation of Ikk Epsilon
Short Talk: Activation of Ikk Epsilon
Harry B. Greenberg,
Stanford University, USA
Rotaviruses and Vaccines: Host Range, Pathogenesis and Innate Immunity - A Ménage a Trois
Rotaviruses and Vaccines: Host Range, Pathogenesis and Innate Immunity - A Ménage a Trois
Nicholas W. Lukacs,
University of Michigan, USA
Talk Title to be Announced
Talk Title to be Announced
Akiko Iwasaki,
HHMI/Yale University School of Medicine, USA
Linking Innate Recognition of Viruses to Adaptive Immunity
Linking Innate Recognition of Viruses to Adaptive Immunity
14:30—16:30
Workshop 2: Host Responses
*
Adolfo García-Sastre,
Mount Sinai School of Medicine, USA
*
Ursula J. Buchholz,
NIAID, National Institutes of Health, USA
Bas Baaten,
Sanford-Burnham-Prebys Medical Discovery Institute, USA
Antiviral Immunity to Influenza Virus at the Aged Nasal Mucosa
Antiviral Immunity to Influenza Virus at the Aged Nasal Mucosa
Tim Beaumont,
AIMM Therapeutics, Netherlands
Human B Cells Specific for the RSV F Prefusion Protein are Highly Prevalent and Efficiently Reduce Respiratory Tract Infection by RSV
Human B Cells Specific for the RSV F Prefusion Protein are Highly Prevalent and Efficiently Reduce Respiratory Tract Infection by RSV
Emily A. Hemann,
University of Washington, USA
The Contribution of Direct Infection of Pulmonary Plasmacytoid Dendritic Cells to Robust CD8 T Cell Responses in the Lungs during Influenza A Virus Infection
The Contribution of Direct Infection of Pulmonary Plasmacytoid Dendritic Cells to Robust CD8 T Cell Responses in the Lungs during Influenza A Virus Infection
Rebecca J. Ortiz Marty,
Nationwide Children's Hospital Research Institute, USA
Epitope Specificity and Function of T-Cell Responses during Acute RSV Bronchiolitis and Memory in Children and Adults
Epitope Specificity and Function of T-Cell Responses during Acute RSV Bronchiolitis and Memory in Children and Adults
Saranya Sridhar,
Imperial College, UK
CD8+ T Cells Correlate with Protection against Symptomatic Illness Following Natural Pandemic Influenza Infection in Humans
CD8+ T Cells Correlate with Protection against Symptomatic Illness Following Natural Pandemic Influenza Infection in Humans
Jeffrey C. Boyington,
NIAID, National Institutes of Health, USA
Rational Design of an Influenza Hemagglutinin Stem Immunogen Enables Elicitation of Stem-Directed Neutralizing Antibodies
Rational Design of an Influenza Hemagglutinin Stem Immunogen Enables Elicitation of Stem-Directed Neutralizing Antibodies
Nicole L. Kallewaard,
MedImmune, USA
Characterization of Novel Human Monoclonal Antibodies that Neutralize all Influenza A Viruses
Characterization of Novel Human Monoclonal Antibodies that Neutralize all Influenza A Viruses
M. Gordon Joyce,
US Military HIV Research Program, USA
Structure-Based Respiratory Syncytial Virus Vaccine Design
Structure-Based Respiratory Syncytial Virus Vaccine Design
14:30—16:30
Workshop 2: Antiviral Strategies
*
Søren Riis Paludan,
University of Aarhus, Denmark
Curt M. Horvath,
Northwestern University, USA
Genomic Analysis Reveals Novel Sites of Virus-Induced RNA Transcription
Genomic Analysis Reveals Novel Sites of Virus-Induced RNA Transcription
Saumendra N. Sarkar,
University of Pittsburgh Cancer Institute, USA
Mechanisms of Antiviral Activity of Human OASL
Mechanisms of Antiviral Activity of Human OASL
Jennifer H. Stuart,
University of Cambridge, UK
Dual Mechanisms of Inhibition of Interferon Responses by Vaccinia Virus Protein C6
Dual Mechanisms of Inhibition of Interferon Responses by Vaccinia Virus Protein C6
John Hiscott,
Vaccine & Gene Therapy Institute of Florida, USA
Host Restriction Factor SAMHD1 Limits Human Retrovirus Infection of Monocytes via STING-Mediated Apoptosis
Host Restriction Factor SAMHD1 Limits Human Retrovirus Infection of Monocytes via STING-Mediated Apoptosis
John W. Schoggins,
University of Texas Southwestern Medical Center, USA
Expression Screens Identify a Viral Bias in Interferon-Induced Effector Specificity and a Requirement for cGAS in Antiviral Immunity
Expression Screens Identify a Viral Bias in Interferon-Induced Effector Specificity and a Requirement for cGAS in Antiviral Immunity
Sumana Sanyal,
University of Hong Kong, Hong Kong
Viral Exploitation of Host Intracellular Trafficking Pathways upon Interferon Induction
Viral Exploitation of Host Intracellular Trafficking Pathways upon Interferon Induction
Silke Paust,
Baylor College of Medicine, USA
Vaccine Induced Memory NK Cells Protect from Lethal Influenza Infection
Vaccine Induced Memory NK Cells Protect from Lethal Influenza Infection
17:00—19:00
Specific Immunity: The Good and the Bad
*
Kanta Subbarao,
WHO Collaborating Centre for Reference and Research on Influenza, Australia
Peter J.M. Openshaw,
Imperial College London, UK
Immunity to Respiratory Syncytial Virus (RSV) Infection
Immunity to Respiratory Syncytial Virus (RSV) Infection
Patrick C. Wilson,
University of Chicago, USA
Diversity Drives the Human B Cell Response to Influenza
Diversity Drives the Human B Cell Response to Influenza
Ethan C. Settembre,
Novartis Vaccines, USA
Improving the Global Influenza Vaccine System
Improving the Global Influenza Vaccine System
Cory J. Knudson,
University of Iowa, USA
Short Talk: Memory CD8 T Cells Provide Protection against Respiratory Syncytial Virus Infection at the Cost of Severe Pulmonary Immunopathology
Short Talk: Memory CD8 T Cells Provide Protection against Respiratory Syncytial Virus Infection at the Cost of Severe Pulmonary Immunopathology
17:00—19:00
Defense from Retroviruses
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
*
Alexander Tarakhovsky,
Rockefeller University, USA
Stephen P. Goff,
Columbia University, USA
Silencing of Retroviral DNAs in Embryonic Stem Cells: Transacting Proteins, Chromatin Modifications, and Timing
Silencing of Retroviral DNAs in Embryonic Stem Cells: Transacting Proteins, Chromatin Modifications, and Timing
Maroof Hasan,
Novartis Institutes for BioMedical Research, Switzerland
Short Talk: Tail-Anchored TREX1 Prevents Liberation of Free Glycans with Immunogenic Potential through a DNase-Independent Function
Short Talk: Tail-Anchored TREX1 Prevents Liberation of Free Glycans with Immunogenic Potential through a DNase-Independent Function
Jan Rehwinkel,
Weatherall Institute of Molecular Medicine, University of Oxford, UK
Nucleotide Starvation: A SAMHD1-Dependent Strategy for Cell-Intrinsic Anti-Retroviral Defense
Nucleotide Starvation: A SAMHD1-Dependent Strategy for Cell-Intrinsic Anti-Retroviral Defense
Jeremy Luban,
University of Massachusetts Medical School, USA
TRIM5 is an Innate Immune Sensor for the HIV-1 Capsid Protein Lattice
TRIM5 is an Innate Immune Sensor for the HIV-1 Capsid Protein Lattice
08:00—11:15
Virulence and Coinfections
*
Monika Bajorek,
Imperial College London, UK
Adolfo García-Sastre,
Mount Sinai School of Medicine, USA
Subversion of Innate Pathways by Influenza Virus
Subversion of Innate Pathways by Influenza Virus
*
Thomas J. Braciale,
University of Virginia, USA
Respiratory Dendritic Cells in the Control of Anti-Viral Effector and Memory T Cell Responses
Respiratory Dendritic Cells in the Control of Anti-Viral Effector and Memory T Cell Responses
Jonathan A. McCullers,
University of Tennessee Health Sciences Center, USA
The Importance of Virus-Mediated Immune Dysfunction in Secondary Bacterial Pneumonia following Influenza
The Importance of Virus-Mediated Immune Dysfunction in Secondary Bacterial Pneumonia following Influenza
Lance K. Blevins,
Wake Forest School of Medicine, USA
Short Talk: Coinfection with S. Pneumoniae Results in Decreases in Both the Quality and Quantity of Influenza Specific CD8+ T Cells
Short Talk: Coinfection with S. Pneumoniae Results in Decreases in Both the Quality and Quantity of Influenza Specific CD8+ T Cells
Agnieszka Rynda-Apple,
Montana State University, USA
Short Talk: Regulation of IFN-? by IL-13 Dictates the Susceptibility to Secondary Post-Influenza MRSA Pneumonia
Short Talk: Regulation of IFN-? by IL-13 Dictates the Susceptibility to Secondary Post-Influenza MRSA Pneumonia
Charles J. Russell,
St. Jude Children's Research Hospital, USA
Short Talk: Dynamics of Primary Parainfluenza Virus Infection and Protection from Reinfection are Determined by the Mode of Transmission while Pathogenesis is Determined by Distinct Viral and Host Factors
Short Talk: Dynamics of Primary Parainfluenza Virus Infection and Protection from Reinfection are Determined by the Mode of Transmission while Pathogenesis is Determined by Distinct Viral and Host Factors
Denise E. de Almeida Nagata,
University of Michigan, USA
Short Talk: Epigenetic Control by TGFbeta1-Inducible SMYD3 H3K4 Methyltransferase Influences iTreg Development and Respiratory Syncytial Virus-Related Disease Progression
Short Talk: Epigenetic Control by TGFbeta1-Inducible SMYD3 H3K4 Methyltransferase Influences iTreg Development and Respiratory Syncytial Virus-Related Disease Progression
08:00—11:15
IFNs and ISGs
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
*
Veit Hornung,
Ludwig-Maximilians-University Munich, Germany
Alexander Tarakhovsky,
Rockefeller University, USA
Epigenetic Regulation of Antiviral Immunity
Epigenetic Regulation of Antiviral Immunity
Andreas Pichlmair,
Max-Planck Institute of Biochemistry, Germany
Nucleic Acid Binding Proteins with Antiviral Properties
Nucleic Acid Binding Proteins with Antiviral Properties
Maria-Carla Saleh,
Institut Pasteur, France
Short Talk: Evidence of Long-Lasting Antiviral Immunity in Insects
Short Talk: Evidence of Long-Lasting Antiviral Immunity in Insects
Sonja M. Best,
NIAID, National Institutes of Health, USA
Short Talk: The Mechanism of Type I Interferon Antagonism by NS5 from Encephalitic Flaviviruses, TBEV and WNV
Short Talk: The Mechanism of Type I Interferon Antagonism by NS5 from Encephalitic Flaviviruses, TBEV and WNV
Gaya K. Amarasinghe,
Washington University in St. Louis, USA
A Structural Element at the 5'-End of Viral RNA Antagonizes IFIT1-Mediated Cell-Intrinsic Immunity
A Structural Element at the 5'-End of Viral RNA Antagonizes IFIT1-Mediated Cell-Intrinsic Immunity
17:00—19:00
Regulation and Resolution of Inflammation
Immunoregulation, resolvins
*
Peter J.M. Openshaw,
Imperial College London, UK
Bali Pulendran,
Stanford University School of Medicine, USA
Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology
Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology
Bruce D. Levy,
Brigham and Women's Hospital, USA
Specialized Pro-Resolving Mediators Promote the Resolution of Pathogen-Mediated Inflammation
Specialized Pro-Resolving Mediators Promote the Resolution of Pathogen-Mediated Inflammation
Ryan A. Langlois,
University of Minnesota, USA
Short Talk: Long-Term Influenza A Virus Infected Cells are Critical for Repair of Respiratory Damage
Short Talk: Long-Term Influenza A Virus Infected Cells are Critical for Repair of Respiratory Damage
17:00—19:00
Antiviral Innate Immunity in Disease
Inflammation and immunopathology, interferonopathies (AGS, lupus).
*
Caetano Reis e Sousa,
Francis Crick Institute, UK
Carla V. Rothlin,
Yale University, USA
Negative Regulation of Type I Interferons
Negative Regulation of Type I Interferons
Roland W. Kolbeck,
MedImmune, LLC, USA
New Approaches to the Treatment of Interferon-Driven Autoimmunity
New Approaches to the Treatment of Interferon-Driven Autoimmunity
Romain Bouziat,
Genentech, Inc., USA
Short Talk: Role of Reoviral Infections and Type 1 Interferon in Celiac Disease
Short Talk: Role of Reoviral Infections and Type 1 Interferon in Celiac Disease
*Session Chair †Invited, not yet responded.
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