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Tivoli Hotel and Congress Center Floorplan

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This meeting took place in 2017

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Gastrointestinal Control of Metabolism (Z6)

Organizer(s) Randy J. Seeley, Matthias H. Tschöp and Fiona M. Gribble
May 9—13, 2017
Tivoli Hotel and Congress Center • Copenhagen, Denmark
Discounted Abstract Deadline: Jan 12, 2017
Abstract Deadline: Feb 9, 2017
Scholarship Deadline: Jan 12, 2017
Discounted Registration Deadline: Mar 9, 2017

Lead Sponsor: Novo Nordisk A/S. Sponsored by MedImmune

Summary of Meeting:
The twin epidemics of obesity and diabetes pose difficult challenges to the health of growing populations around the globe. A wide array of recent data link the gastrointestinal tract to the etiology of these diseases. Moreover, some of the most innovative approaches to treat obesity, diabetes and related metabolic disorders involve direct manipulation of the GI tract or manipulation of the signals that come from the GI tract. To this end, an important goal of this meeting will be to highlight a wide range of methodologies that can be brought to understand GI function as it relates to obesity and diabetes. One of the primary factors slowing research on this topic is that investigators with interest in GI function and metabolic disease come from a wide range of disciplines that are not generally represented at scientific meetings. A key goal of this meeting is to bring together leading investigators from around the globe. Putting investigators who have been revealing function of the GI tract together with those sophisticated in metabolism – as well as encouraging early-career investigators to delve into this field – will be crucial to accelerate current work looking for novel therapeutic strategies. An important advance in our understanding of the GI tract is the appreciation of it as a major endocrine organ. A key component of the action of those GI hormones is their interaction with both the peripheral and central nervous system. Consequently, this meeting will be held jointly with a meeting that focuses on the “Neuronal Control of Appetite, Metabolism and Weight.” This is an ideal opportunity to bring together those who study how the GI tract generates these signals with those who study the neural systems that are targets for these signals.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time

The meeting will begin on Tuesday, May 9 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, May 13 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, May 14 in order to fully experience the meeting.


Arrival and Registration

Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Brasserie 3



Individual Hotel
Welcome and Keynote Session (Joint)

Tivoli Congress Hall
* Lora K. Heisler, Rowett Institute, University of Aberdeen, UK

* Randy J. Seeley, University of Michigan, USA

Stephen O'Rahilly, University of Cambridge, UK
Metabolic Disease: Lessons from Natural Human Variation

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
The Intestinal Stem Cell Niche – At the Base of It All

Coffee Break

Nutrient Sensing and Gut Signaling (Joint)

Tivoli Congress Hall
* Andrew Butler, St. Louis University, USA

* Fiona M. Gribble, University of Cambridge, UK

Ronald M. Evans, HHMI/The Salk Institute, USA
Gut Feelings: Systemic Reach of Intestinal FXR

Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Bile Acid Signaling in Metabolic Disease

Joshua Thaler, University of Washington, USA
Short Talk: Prevention of Microglial Inflammatory Signaling Reduces Susceptibility to Diet-Induced Obesity

On Own for Lunch

Poster Setup

Poster Viewing

Workshop 1

* Timo D. Müller, Institute for Diabetes and Obesity, Germany

Anne-Charlotte Jarry, Paris Diderot University, France
Neuromedin U Blocks Gastric Emptying through Vagal-Dependent Mechanisms and Improves Oral Glucose Tolerance

Geke Aline Boer, University of Copenhagen, Biomedical Institute, Denmark
Acute Reduction of GIP: Effects on Lipid and Bone Metabolism

Emily C. Bruggeman, University of Texas Southwestern Medical Center, USA
Ghrelin Receptor Deletion Increases Morbidity and Mortality in a Prader-Willi Syndrome Mouse Model

Natalia Petersen, University of Copenhagen, Denmark
"Tailoring" the Intestinal Epithelium for Type 2 Diabetes Treatment: Modulation of L-Cell Differentiation

Hai-Bin Ruan, University of Minnesota, USA
Diet- and Microbiota-Sensitive Intestinal O-GlcNAc Signaling Controls Enteroendocrine Cell Development and Function

Sara Lind Jepsen, University of Copenhagen, Denmark
Somatostatin Regulates GLP-1 Secretion through the Somatostatin Receptor Subtype 2

Workshop 1: Disorders and Diseases Associated with Weight Loss
Anorexia nervosa, binge eating disorder, PTSD, cancer cachexia and others

* Thomas Alexander Lutz, University of Zürich, Switzerland

* Petra Kotzbeck, Medical University of Graz, Austria

Yong Xu, Baylor College of Medicine, USA
5-HT Neurons and Eating Disorders

Manon Duquenne, INSERM Université Lille 2, France
A Role for Tanycyte Exocytosis in the Central Control of Energy Homeostasis?

Christian Stockmann, University of Zurich, Switzerland
The Role of Vascular Endothelial Growth Factor-A in the Context of Cancer Cachexia and Chemotherapy

Kevin G. Murphy, Imperial College London, UK
Investigating Disorders Associated with Weight Loss

Serge Luquet, Université Paris Diderot, France
Palatability Can Drive Feeding Independent of AgRP Neurons

Christin Kosse, Francis Crick Institute, UK
Functional Properties of GAD65 Neurons in the Lateral Hypothalamus

Yunlei Yang, SUNY Upstate Medical University, USA
Deciphering Anorexigenic Septohypothalamic Feeding Circuits

Coffee Available

Gut Bacteria as Cause and Treatment of Metabolic Diseases
Gut bacteria as cause and treatment of metabolic diseases.

* Gilles Mithieux, INSERM, France

Fredrik Bäckhed, University of Gothenburg, Sweden
Microbial Signaling from the Gut and Resulting Effects on Host Metabolism

Martin J. Blaser, New York University School of Medicine, USA
Effects of the Early Life Microbiota on the Development of Metabolic Illnesses

Karine Clément, INSERM / Sorbonne Universite, France
Microbiome as Therapy

Edna A. Trujillo, University of Wisconsin-Madison, USA
Short Talk: Metabolite Profiling of Plasma and Cecum Elucidates the Impacts of Host Genetics and Environment on the Gut Microbiota

Interactions between Ingestive Signals and Reward Circuits

* Matt Carter, Williams College, USA

* Agatha A. van der Klaauw, University of Cambridge, UK

Michael A. Cowley, Monash University, Australia
Leptin Receptor Expressing Neurons of the Dorsomedial Hypothalamus Play a Limited Role in Regulating Food Intake but a Critical Role in Regulating Metabolism

Suzanne Lee Dickson, Sahlgrenska Academy, Gothenburg University, Sweden
Brain Ghrelin Signaling and Food Reward Behavior

Christian Lüscher, University of Geneva, Switzerland
Feeding Circuits that Can Override Metabolic Needs

Claire J. Foldi, Monash University, Australia
Short Talk: CNS Reward Pathways in Anorexia Nervosa: Insights from a Rat Model

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Poster Session 1




Individual Hotel
Stem Cells, Gut-Pancreas Development I

* Praveen Sethupathy, Cornell University, USA

Fiona M. Gribble, University of Cambridge, UK
The Biology of Enteroendocrine Cells

Heiko Lickert, Institute of Diabetes and Regeneration, Germany
Dissecting Intestinal Stem Cell Lineage Decisions

Coffee Break

James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Human Pluripotent Stem Cell-Derived Gastrointestinal Organoids as New Models to Study Metabolic and Digestive Diseases

Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Loss of Beta Cell Identity Related to Diabetes

John Furness, University of Melbourne, Australia
Short Talk: Diversity of Enteroendocrine Cells between Species and Regions Studied at a Cellular and Subcellular Level

Sandra Guilmeau, INSERM U1016 Institut Cochin, CNRS UMR 8104, France
Short Talk: Contribution of ChREBP in Intestinal GLP-1 Production

Emerging Energy Homeostasis Neurocircuitry

Tivoli Congress Hall
* Qingchun Tong, University of Texas Medical School, USA

* Matthew R. Hayes, University of Pennsylvania, USA

Sabrina Diano, Yale University School of Medicine, USA
Mitochondrial Control of the Melanocortin System

Martin G. Myers, Jr., University of Michigan, USA
LepRb Signaling and the Regulation of Transcription

Coffee Break

Joseph T. Bass, Northwestern University, USA
Identification of an SCN-AgRP Circadian Neurocircuit Regulating Obesity and Systemic Metabolism

Lori M. Zeltser, Columbia University, USA
Gene X Environment Interactions that Promote Anorexia-Like Behavior

Ali Guler, University of Virginia, USA
Short Talk: Dopamine Signaling in the SCN Regulates Circadian Consumption of High-Fat Diet

Mathias Treier, Max-Delbrueck-Center for Molecular Medicine, Germany
Short Talk: Identification of the Hypothalamic Circuit Maintaining Food Foraging

On Own for Lunch

Poster Setup

Poster Viewing

Coffee Available

Signaling from Periphery to Brain to Modulate Energy Balance (Joint)

Tivoli Congress Hall
* Suzanne M. Appleyard, Washington State University, USA

* David Olson, University of Michigan, USA

Jeffrey M. Friedman, Rockefeller University, USA
Neural Control of Food Intake, Locomotion and Glucose Metabolism

Randy J. Seeley, University of Michigan, USA
How the Gut Regulates Metabolic Status

Ivan E. de Araujo, Icahn School of Medicine at Mount Sinai, USA
What Does Sugar Do to the Brain? Circuit Logic for Sugar Sensing

Celine E. Riera, Cedars-Sinai Medical Center, USA
Short Talk: The Sense of Smell Impacts Metabolic Health and Obesity

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Tivoli Congress Hall
Poster Session 2




Individual Hotel
Controversies in Obesity/Diabetes Treatment: Surgery vs. Devices vs. Medicines - What Does the Future Hold?

* Ruth E. Gimeno, Eli Lilly and Company, USA

Jens Juul Holst, University of Copenhagen the Panum Institute, Denmark
The Role of the Gut in the Development of Type 2 Diabetes

Tricia M. Tan, Imperial College London, UK
Triple Gut Hormones as Therapy

Coffee Break

David E. Cummings, University of Washington, USA
Metabolic Surgery: Mechanisms and Use of “Bariatric” Operations to Treat Type 2 Diabetes

Niels Vrang, Gubra, Denmark
Short Talk: The Effect of FXR, PPAR-α/δ and GLP-1 Agonism on Liver Disease in Diet-Induced Obese and Biopsy-Confirmed Mouse Models of NASH

Wendy M. McKimpson, Columbia University, USA
Short Talk: Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment

Makoto Fukuda, Baylor College of Medicine, USA
Short Talk: Gut Hormone GIP Drives Hypothalamic Pathogenesis of Obesity

Hypothalamic Signals Modulating Hunger and Complex Behavior

Tivoli Congress Hall
* Clemence Blouet, University of Cambridge, UK

* J. Nicholas Betley, University of Pennsylvania, USA

Scott M. Sternson, HHMI/Janelia Research Campus, USA
Motivational Mechanisms Controlling Hunger

Garret D. Stuber, University of North Carolina at Chapel Hill School of Medicine, USA
Lateral Hypothalamic Circuits for Feeding and Reward

Coffee Break

Tamas L. Horvath, Yale School of Medicine, USA
Appetite Circuits in the Regulation of Complex Behavior

Roger D. Cone, University of Michigan, USA
Melanocortins: From Pharmacology to Pharmacotherapy

Tatiana Korotkova, Max Planck Institute for Metabolism Research, Germany
Short Talk: Gamma Oscillations Organize Top-Down Signaling to Hypothalamus and Enable Food-Seeking

Marcelo O. Dietrich, Yale University, USA
Short Talk: Behavioral Ontogeny of Hypothalamic Neurons

On Own for Lunch

Poster Setup

Poster Viewing

Workshop 2

* Lene Jessen, Zealand Pharma, Denmark

Maria H. Hauge, Copenhagen University, Denmark
Gq and Gs Signaling Acting in Synergy to Control GLP-1 Secretion

Youngjung Kim, Icahn School of Medicine at Mount Sinai, USA
Pyruvate Kinase as a Novel Metabolic Regulator of Beta Cell Loss in Diabetes

Alyce M. Martin, Flinders University, Australia
Gut Serotonin Is a Signaling Nexus between the Gut Microbiome and Host Metabolism

Louise Olofsson, University of Gothenburg, Sweden
Role of the Gut Microbiota in Diet-Induced Hypothalamic Inflammation

Anette Christ, University of Massachusetts Medical School, USA
Long-Term Epigenetic Re-Programming of Myeloid Precursor Cells in a Hyperlipidemic Environment

Nadja Gebert, Leibniz Institute on Aging, Germany
Age and Diet Affect the Intestinal Crypt Proteome

Jonathan D. Douros, Duke University, USA
Increased Glucose-Dependent Insulinotropic Polypeptide (GIP) Secretion and Signaling Improves Beta-Cell Function following Vertical Sleeve Gastrectomy (VSG)

Coffee Available

Stem Cells, Gut-Pancreas Development II

* Lori Sussel, University of Colorado Anschutz Medical Campus, USA

Andrew B. Leiter, University of Massachusetts Medical School, USA
Differentiation of Enteroendocrine Cells

Praveen Sethupathy, Cornell University, USA
Microbiota, MicroRNAs, and Intestinal Stem Cell Function

Susumu Seino, Kobe University Graduate School of Medicine, Japan
Beta-Cell Glutamate Signaling Is Critical for Incretin-Induced Insulin Secretion

William L. Holland, University of Texas Southwestern Medical Center, USA
Short Talk: Glucagon Receptor Inhibition Restores Functional Beta Cell Mass and Reverses Hyperglycemia in Type-1 Diabetic Mice

Cutting-Edge Approaches in Obesity Research

Tivoli Congress Hall
* Jeffrey M. Zigman, University of Texas Southwestern Medical Center, USA

* Daniela Cota, Neurocentre Magendie, France

Stephen Liberles, Harvard Medical School, USA
Molecular and Genetic Analysis of the Vagus Nerve

Andres Lozano, University of Toronto, Toronto Western Hospital, Canada
Deep Brain Stimulation to Treat Obesity or Anorexia

Kevin L. Grove, Novo Nordisk, USA
Obesity-Related Genes in the Rhesus Macaque

John N. Campbell, University of Virginia, USA
Short Talk: A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Tivoli Congress Hall
Poster Session 3




Individual Hotel
Poster Setup

Poster Viewing

Pharmacotherapies for Obesity and Type 2 Diabetes (Joint)

Tivoli Congress Hall
* Malcolm J. Low, University of Michigan, USA

* Roger A. Adan, Brain Center Rudolf Magnus, Netherlands

Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
The Control of Gut Hormone Activity: Role of Dipeptidyl Peptidase-4

Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
Gut Peptide Combination Therapy to Treat Obesity

Coffee Break

Lora K. Heisler, Rowett Institute, University of Aberdeen, UK
Modifying CNS 5-HT Circuits to Reverse Obesity and Type 2 Diabetes

Ruth E. Gimeno, Eli Lilly and Company, USA
Current and Emerging Targets for Obesity Treatment

Tamer Coskun, Eli Lilly & Company, USA
Short Talk: Confirming Efficacy of Celastrol and Withaferin A in a Diet-Induced Obese (DIO) Mouse Model

Shamina M. Rangwala, Pfizer, USA
Short Talk: Gdf15-Mediated Mechanisms of Food Intake Reduction and Weight Loss


Tivoli Congress Hall
Poster Session 4

Workshop 2: CNS Regulation of Adipose Tissue
CNS regulation of white and brown fat and browning of white fat

Tivoli Congress Hall
* Kate Ellacott, University of Exeter Medical School, UK

* Mads Tang-Christensen, Novo Nordisk A/S, Denmark

Justin J. Rochford, University of Aberdeen, UK
Inhibition of Gamma Synuclein Directly Alters Adipocyte Mitochondrial Function and Lipid Metabolism

Barbara Cannon, Stockholm University, Sweden
Peripheral and Central Regulation of UCP1-Dependent Thermogenesis

Miguel López, Universidad de Santiago de Compostela, Spain
Hypothalamic AMPK: A Canonical Regulator of Energy Balance

Sangho Yu, Pennington Biomedical Research Center, USA
Preoptic Leptin Function Modulates Diet-Induced Weight Gain

Claire H. Feetham, University of Manchester, UK
Prolactin-Releasing Peptide Neurones Project from Dorsomedial to Paraventricular Hypothalamic Nucleus to Affect Energy Expenditure

Pablo B. Martinez de Morentin, Rowett Institute of Nutrition and Health, UK
Raphe Pallidus Serotonin Cells Modulate Brown Adipose Tissue Thermogenesis

Coffee Available

Novel Aspects of Gut Function

* John Furness, University of Melbourne, Australia

Thue W. Schwartz, University of Copenhagen, Denmark
Nutrient and Gut Microbiota Metabolite Sensing through GPCRs in the GI Tract

Gilles Mithieux, INSERM, France
Central Regulation of Metabolism Initiated by Intestinal Gluconeogenesis

Tony K.T. Lam, Toronto General Research Institute, Canada
Gut Nutrient Sensing

Programming Obesity: Early Environmental Influences

Tivoli Congress Hall
* Michael Krashes, NIDDK, National Institutes of Health, USA

* Alicja A. Skowronski, Columbia University, USA

Elinor L. Sullivan, Oregon National Primate Research Center, USA
Maternal Metabolic and Dietary Environmental Influences on Offspring Metabolic Health and Behavior

John Speakman, Institute of Genetics and Developmental Biology, CAS, China
The Impact of Maternal Diet on Hypothalamic Remodeling during Development and Subsequent Susceptibility to High Fat Diets in the Mouse

Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Effect of Insulin on Brain Development and Metabolic Programming

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Tivoli Congress Hall
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Tivoli Congress Hall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Tivoli Congress Hall



*Session Chair †Invited, not yet responded.

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