Keystone Symposia

Eldorado Hotel & Spa Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2020



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Brain Therapeutics: Disruptive Technologies and Opportunities (Q3)


Organizer(s) Maria-Jesus Blanco, Kalpana M. Merchant and Mabel Loza
February 16—19, 2020
Eldorado Hotel & Spa • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 29, 2019
Abstract Deadline: Nov 19, 2019
Scholarship Deadline: Oct 29, 2019
Discounted Registration Deadline: Dec 17, 2019

Supported by the Directors' Fund


Summary of Meeting:
CNS disorders represent a major unmet medical need. The associated societal burden is becoming unsustainable due to changing demographics (e.g., aging population). Despite major investments in basic and translational research by government and non-profit institutions world-wide, pharmaceutical companies and equity investors continue to view brain therapeutics as a relatively risky area of investment. This Keystone Symposia conference will highlight groundbreaking technologies and new approaches to de-risk CNS-targeted therapies and demonstrate how interdisciplinary integration has the potential to overcome the contemporary challenges of CNS drug development. One of the unique features of this conference is that it brings together a diversity of scientists, who rarely participate in the same meetings, in order to create an environment for disruptive innovation. Invited speakers will provide both general and technical presentations to engage participants in topics like disease biology-informed target selection, novel medicinal chemistry approaches, biomarkers, and clinical trial design. Advances in technologies such as genomics, imaging and brain delivery will be highlighted throughout. Our featured speakers hail from around the world and represent both public and private sector and young and established scientists. The aim of this conference is to create a space for collaboration that helps attendees address the unmet medical need of CNS disorders even after it has ended. Finally, this meeting will be paired with the Keystone Symposia conference on Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus. The goal of this paring is to stimulate cross-disciplinary thinking about CSF-based medicinal therapies.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 16 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, February 19 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, February 20 in order to fully experience the meeting.

SUNDAY, FEBRUARY 16

16:00—20:00
Arrival and Registration

Cava Santa Fe
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Cava Santa Fe

MONDAY, FEBRUARY 17

07:00—08:00
Breakfast

Anasazi Ballroom
08:00—09:00
Welcome and Keynote Address

Eldorado A
* Maria-Jesus Blanco, Sage Therapeutics, USA

Darryle D. Schoepp, , USA
Neuroscience Therapeutics: Current Pipeline Challenges and Lessons Along the Way

08:00—09:00
Welcome and Keynote Address

Eldorado B
* Edwin S. Monuki, University of California, Irvine, USA

* Maiken Nedergaard, University of Rochester, USA

* Maria Lehtinen, Harvard Medical School, USA

Kari K. Alitalo, University of Helsinki, Finland
Role of Lymphangiogenic Factors in Cerebral Fluid Flow and Neuropathological Processes in the CNS

09:00—11:30
Challenges and Opportunities for Brain Therapeutics: Preclinical to Clinical Translation

Eldorado A
* Maria-Jesus Blanco, Sage Therapeutics, USA

Kalpana M. Merchant, Vincere Biosciences, Inc., USA
De-Risking Approaches for Disease-Modifying Therapies for Parkinson’s Disease: Opportunities and Challenges Exemplified by the Parkin Activator Program

Coffee Break

Chas Bountra, University of Oxford, UK
New Technologies, Collaborations and Processes, to Accelerate the De-Risking of Pioneer Drug Targets, for Neuro-Psychiatric Conditions

Shoichiro Ando, Niigata University, Japan
Short Talk: Gene Therapy for DRPLA Model Mice by AAV-Delivered CRISPR / Cas9

Trevor John Gonzalez, Duke University, USA
Short Talk: Engineering Synthetic Circular RNAs for AAV Mediated Expression in the Brain

Chao-Hsien Chen, University of Texas MD Anderson Cancer Center, USA
Short Talk: Reversal of Neurodegeneration through Clearance of pTau by Engineered Monocytes

Andrea Crotti, Astellas Pharma, USA
Short Talk: BIN1 Favors the Spreading of Tau via Extracellular Vesicles

09:00—11:30
Choroid Plexus and CSF Regulation of Stem Cells

Eldorado B
* Edwin S. Monuki, University of California, Irvine, USA

Norman Ruthven Saunders, University of Melbourne, Australia
The Choroid Plexus: Mechanisms that Limit Drug Entry into the Developing Brain

Coffee Break

Nanna MacAulay, University of Copenhagen, Denmark
Mechanism of CSF Secretion – Conventional Osmosis versus Active Water Transport

Maria Lehtinen, Harvard Medical School, USA
Illuminating the Choroid Plexus

Neil Dani, Boston Children's Hospital, USA
Short Talk: A Cellular and Spatial Map of the Choroid Plexus across Ventricles and Ages

Annarita Patrizi, German Cancer Research Center, Germany
Short Talk: Rescuing Cortical Features in Rett Syndrome through the Choroid Plexus

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Anasazi Ballroom
13:00—22:00
Poster Viewing

Anasazi Ballroom
14:30—16:30
Roundtable: Collaboration & Knowledge Integration Models for Successful Brain Therapeutics

Eldorado A
* Mabel Loza, BioFarma Research Group, University of Santiago de Compostela, Spain

James E. Audia, Chicago Biomedical Consortium, USA
Drug Discovery in the Academic and Not-For-Profit Community

Chas Bountra, University of Oxford, UK

Sohini Chowdhury, Michael J. Fox Foundation, USA

15:30—16:30
Workshop 1

Eldorado B
* Julie Siegenthaler, University of Colorado Denver, USA

Alexandra E. Hochstetler, Indiana University Purdue University Indianapolis, USA
Functional Studies of Ion Transport in Choroid Plexus Epithelial Cells

Engin Deniz, Yale University, USA
Building Xenopus as a Model System for Hydrocephaly and Ependymal Ciliogenesis

Eri Iwasawa, Cincinnati Children's Hospital Medical Center, USA
Neuroinflammation and Impaired Neural Differentiation in a Novel Rat Model of Neonatal Hydrocephalus Lacking Motile Cilia-mediated CSF Flow

Huixin Xu, Boston Children's Hospital, USA
Developmental Control of Cerebral Fluid Distribution and CSF-K+ by Choroid Plexus

Jo Stratton, McGill University, Canada
Ependymal Cells: Their Transcriptional Landscape and Role in Brain Injury

Jessie Newville, University of New Mexico, USA
Disruption and Rescue of Ependymal Motile Cilia Function in a Model of Posthemorrhagic Hydrocephalus of Prematurity

Haley Masters, University of California, Irvine, USA
Single Cell Transcriptomic and Cell Biological Analysis of Human Choroid Plexus Epithelial Cells Derived from Pluripotent Stem Cells

Michael Neel, University of California, Irvine, USA
Characterization of an Aging-Related Amyloid of the Human Choroid Plexus

16:30—17:00
Coffee Available

Concourse
17:00—19:00
Advances in Technologies to Garner Insights into Disease Biology

Eldorado A
* Chas Bountra, University of Oxford, UK

Edoardo Marcora, Icahn School of Medicine at Mount Sinai, USA
From Human Genetics to Causal Biology in Alzheimer's Disease

Lena F. Burbulla, Northwestern University, USA
Modeling Pathogenesis of Parkinson's Disease Using iPSC

Damian G. Wheeler, Translucence Biosystems, Inc, USA
Short Talk: Brain-Wide Cellular Resolution Measurement of Neuronal Activity and Neuroinflammation

Xiaoqing Li, University of Texas at Dallas, USA
Short Talk: Optical Opening of the Blood-Brain Barrier by Laser Excitation of Vasculature-Targeting Plasmonic Nanoparticles

Daniela Lecca, NIA, National Institutes of Health, USA
Short Talk: Neuroinflammation as a Therapeutic Target in Neurodegenerative Diseases

17:00—19:00
Glymphatics

Eldorado B
* Jonathan Kipnis, Washington University School of Medicine, USA

Maiken Nedergaard, University of Rochester, USA
Sleep Regulation and Disease Roles of the Glymphatic System

Jeffrey J. Iliff, University of Washington, USA
Evidence for the Role of Glymphatic Dysfunction in the Development of Alzheimer’s Disease

Helene Benveniste, Yale School of Medicine, USA
Glymphatic Flow, Regulation and Function

Iben Lundgaard, University of Lund, Sweden
Short Talk: Cerebral Blood Flow Drives Efflux of CSF from the Ventricular System

Judith de Vos, Amsterdam University Medical Center, Netherlands
Short Talk: The Imaging Cryomicrotome: A Setup for Large Volume 3D Mesoscopic Visualization

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
19:30—22:00
Poster Session 1

Anasazi Ballroom

TUESDAY, FEBRUARY 18

07:00—08:00
Breakfast

Anasazi Ballroom
08:00—11:00
Integrating Novel Medicinal Chemistry Approaches Targeting the Brain

Eldorado A
* James E. Audia, Chicago Biomedical Consortium, USA

Anastasia Khvorova, University of Massachusetts Medical School, USA
RNAi-Based Modulation of Gene Expression in Central Nervous System

Jacob M. Hooker, Harvard Medical School, USA
Integrating PET Tracers into CNS Drug Discovery: Impact on the Discovery of Novel HDAC Ligands

Coffee Break

Maria-Jesus Blanco, Sage Therapeutics, USA
Discovery of Allosteric Modulators of GABAA Receptor for CNS Disorders

Paula Perez Pardo, Utrecht University, Netherlands
Short Talk: Positive Effects of Small Molecule Tryptophan-2,3-Dioxygense Inhibitors on Motor and Non-Motor Symptoms in a Mouse Model of Parkinson’s Disease

Xavier Barril, Gain Therapeutics, Spain
Short Talk: Correcting Protein Misfolding with Structurally Targeted Allosteric Regulators (STAR): Applications in Rare Diseases and Brain Therapeutics

08:00—11:15
Lymphatics and CSF Dynamics

Eldorado B
* Maiken Nedergaard, University of Rochester, USA

Jonathan Kipnis, Washington University School of Medicine, USA
Lymphatic-Glymphatic Roles in Aging and Disease

Erik N.T.P. Bakker, University of Amsterdam, Netherlands
The Impact of High Blood Pressure on the Brain: Studies in Spontaneously Hypertensive Rats

Coffee Break

Steffi Dreha-Kulaczewski, University Medical Center Göttingen, Germany
Breathe to Drive CSF Flow

Julie Siegenthaler, University of Colorado Denver, USA
Short Talk: Origins, Development and Function of the Arachnoid Barrier Layer, a Key Component of the Blood-CSF Barrier

Ji Hoon Ahn, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Meningeal Lymphatic Vessels at the Skull Base Drain Cerebrospinal Fluid

Fengfei Ding, University of Rochester Medical Center, USA
Short Talk: Chronic Sleep Fragmentation Alters the Brain Glymphatic Function

Humberto Mestre, University of Rochester Medical Center, USA
Short Talk: Cerebrospinal Fluid Influx Drives Acute Ischemic Tissue Swelling

John R. Cirrito, Washington University, USA
Short Talk: Using Micro-Immunoelectrodes to Study Rapid Mechanisms of Aß Clearance from the Brain Interstitial Fluid of Mice

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Anasazi Ballroom
13:00—22:00
Poster Viewing

Anasazi Ballroom
14:30—16:30
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis. Maximum attendance: 60.

Zia Ballroom
Maria-Jesus Blanco, Sage Therapeutics, USA

Kalpana M. Merchant, Vincere Biosciences, Inc., USA

Maria Lehtinen, Harvard Medical School, USA

Edwin S. Monuki, University of California, Irvine, USA

Maiken Nedergaard, University of Rochester, USA

Jacob M. Hooker, Harvard Medical School, USA

16:30—17:00
Coffee Available

Concourse
17:00—19:00
Diagnostic and/or Disease-State Biomarkers

Eldorado A
* Darryle D. Schoepp, , USA

Steffany A.L. Bennett, University of Ottawa, Canada
Remote Presentation: Lipidomic-Based Insights into Disease Mechanisms: A Targeted Lipidomics Discovery Pipeline for Network and Flux Analysis

Gwenn A. Garden, University of Washington, USA
Emerging Glial Biomarkers of CNS Disease

David Nguyen, Sage Therapeutics, USA
Novel Digital Technologies towards CNS Translational Insights

Jagan A. Pillai, Cleveland Clinic, USA
Short Talk: Pathway Based Analysis to Evaluate Inflammatory Analytes of Significance for Therapeutic Targeting in Alzheimer’s Disease

17:00—19:00
Integrating Brain-Body Signaling

Eldorado B
* Maria Lehtinen, Harvard Medical School, USA

Fiona Doetsch, University of Basel, Switzerland
Choroid Plexus Regulation of Adult Neural Stem Cells

Claire Wyart, Institut du Cerveau et de la Moelle Epinière, France
Origin and Role of the Cerebrospinal Fluid Bidirectional Flow in the Central Canal

Craig Ferris, Northeastern University, USA
Imaging the Effect of the Circadian Light-Dark Cycle on the Glymphatic System in Awake Rats

Laura Lewis, Boston University, USA
Coordinated Neural, Vascular, and Cerebrospinal Fluid Dynamics in Human Sleep

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
19:30—22:00
Poster Session 2

Anasazi Ballroom

WEDNESDAY, FEBRUARY 19

07:00—08:00
Breakfast

Anasazi Ballroom
08:00—11:00
Ensuring Target Engagement: Innovative Approaches Towards Neuroimaging and Brain Delivery

Eldorado A
* Damian G. Wheeler, Translucence Biosystems, Inc, USA

Tetsuya Suhara, National Institutes for Quantum and Radiological Science and Technology, Japan
Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development

Lisa L. Shafer, Cerebral Therapeutics, Inc., USA
Emerging Strategies for Brain Drug Delivery: Case Study Applications

Coffee Break

Robert G. Thorne, Denali Therapeutics, USA
Characterizing Fusion Protein Transport Across CNS Barriers: Leveraging Imaging and Other Novel Methods to Assess Brain Delivery

Frances G. Ghinger, University of Maryland, Baltimore County, USA
Short Talk: Optical Imaging of Ventromedial Prefrontal Cortex Activity Following Chronic Stress

08:00—11:15
Choroid Plexus and CSF Regulation of Neuroimmune Responses

Eldorado B
* Fiona Doetsch, University of Basel, Switzerland

Roosmarijn E. Vandenbroucke, VIB-UGent Center for Inflammation Research, Belgium
Choroid Plexus-Derived Extracellular Vesicles as Mediators of Neuroinflammation

Jean-François Ghersi-Egea, Lyon Neurosciences Research Center, France
Antioxidant Defence at the Choroid Plexus Influences CSF Inflammation during Systemic Perinatal Injuries

Coffee Break

Michal Schwartz, Weizmann Institute of Science, Israel
Choroid Plexus Regulation of the Neuroimmune Response

Jan Remsik, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Immunological Determinants of Leptomeningeal Metastasis

Frederick B. Shipley, Harvard University, USA
Short Talk: Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus

Marcus Stoodley, Macquarie University, Australia
Short Talk: Physiological Drivers of Fluid Flow in the Spinal Subarachnoid Space and Spinal Cord

Gabriel Jensen, University of Maine, USA
Short Talk: The Meninges and Choroid Plexus are Prominent Telomerase Reverse Transcriptase-Expressing Adult Stem Cell Niches in the Mouse Brain

June Goto, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Impaired Glymphatic Flow and The Delayed Neural Differentiation in CCDC39-Deficient Rat Model of Neonatal Hydrocephalus

11:00—17:00
On Own for Lunch

15:30—16:30
Workshop 2

Eldorado B
* Iben Lundgaard, University of Lund, Sweden

Jin Cui, Boston Children's Hospital, USA
Choroid Plexus as a Site of Immune Activation in a Model of Autism Spectrum Disorders

Marco Fanous, Duke University, USA
Aquaporin 4 Regulates Adeno-Associated Viral (AAV) Transport across the Blood Brain Barrier

Darshan Sapkota, Washington University, USA
Stop Codon Readthrough of Aqp4 Generates a Novel AQP4 Isoform with Pathophysiological Significance

Hannah Elizabeth Jones, University of Colorado Anschutz Medical Campus, USA
Developmental Timing and Origins of Perivascular Brain Fibroblasts

Daphne M.P. Naessens, Amsterdam UMC, Netherlands
Elucidating Brain Water Management in Spontaneously Hypertensive Rats

Dakota E R DeFreitas, Washington University in St. Louis, USA
Evaluation of CSF Distribution in Post-Hemorrhagic Hydrocephalus Rat Brain using Gold Nanoparticle Enhanced X-ray Nanotomography

Cameron Sadegh, Harvard University, USA
Choroid Plexus Epithelia Respond Rapidly to Hemorrhage to Minimize Ventriculomegaly Prior to Global Compensatory Increases in CSF Reabsorption

Jordan C. Xu, University of California, Irvine, USA
Dural Lympathic Changes in Normal Pressure Hydrocephalus

Andrew T. Hale, Vanderbilt University School of Medicine, USA
Integration of Human Genetics and Mutli-Omics Data Implicates Novel Pathways in Hydrocephalus

Arie Horowitz, , USA
Cerebrospinal Fluid Signature of Hydrocephalus

16:30—17:00
Coffee Available

Concourse
17:00—18:45
Innovative Therapeutic Approaches Targeting the Brain

Eldorado A
* Kalpana M. Merchant, Vincere Biosciences, Inc., USA

Aletta D. Kraneveld, University of Utrecht, Netherlands
Parkinson’s Disease: No Guts No Glory

Giorgia Quadrato, University of Southern California, USC Stem Cell, USA
Modeling Human Brain Development and Disease at Single Cell Resolution with Organoids

Shun Mitsui, Tokai University School of Medicine, Japan
Short Talk: Neural Cell-Specific SQSTM1 Deficiency Accelerates the Onset of Disease in an ALS Mouse Model

Nicholas T. Hertz, Mitokinin Inc., USA
Short Talk: Small Molecule Activators of PINK1 Activity Rescue Sporadic PD Associated alpha-Synuclein Pathology

Taotao Lao, Massachusetts General Hospital/ Harvard Medical School, USA
Short Talk: TREML2 Regulates Microglia Functions in an Alzheimer’s Disease Model

17:00—19:00
Diagnostics and Therapies

Eldorado B
* Jeffrey J. Iliff, University of Washington, USA

Christopher Moore, Brown University, USA
Remote Presentation: A Systems Approach to the Choroid Plexus

Edwin S. Monuki, University of California, Irvine, USA
Towards a Choroid Plexus-Based Regenerative Medicine

Kristopher T. Kahle, Yale School of Medicine, USA
A Role for Inflammation: TLR-4-mediated Cerebrospinal Fluid Hypersecretion in Post-hemorrhagic and Post-infectious Hydrocephalus

Patricia I. Dickson, Washington University, USA
CSF Delivery of Therapeutics

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Eldorado A
19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions

Eldorado B
Edwin S. Monuki, University of California, Irvine, USA

Maria Lehtinen, Harvard Medical School, USA

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Anasazi Ballroom

THURSDAY, FEBRUARY 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS115402-01

Funding for this conference was made possible (in part) by 1R13NS115402-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This grant is co-funded by the National Institute Of Neurological Disorders And Stroke (NINDS) and the National Center For Advancing Translational Sciences (NCATS).


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Biogen


Sage Therapeutics


Vincere Biosciences, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179